Revisiting Cardiac Cellular Composition.

abstract：:Morphogenesis and developmental remodeling of cardiovascular tissues involve coordinated regulation of cell proliferation and apoptosis. In the heart, clear evidence points toward focal apoptosis as a contributor to development of the embryonic outflow tract, cardiac valves, conducting system, and the developing coron...

journal_title：Circulation research

authors： Fisher SA,Langille BL,Srivastava D

更新日期：2000-11-10 00:00:00

abstract：:Bradykinin relaxes arterioles on the brain's surface. This response is endothelium-dependent. The data presented here confirm the hypothesis that hydroxyl free radical mediates this response and may be the endothelium-dependent relaxing factor for bradykinin in this microvascular bed. The response to a locally applied...

journal_title：Circulation research

authors： Rosenblum WI

更新日期：1987-10-01 00:00:00

abstract：:The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduced compared with the young adult heart. Since endogenous adenosine exerts an antiadrenergic action in the heart, this study was undertaken to determine if the basal endogenous level of myocardial adenosine increases wit...

journal_title：Circulation research

authors： Dobson JG Jr,Fenton RA,Romano FD

更新日期：1990-05-01 00:00:00

abstract：:Blood pressure (BP) control in patients with hypertension is variable worldwide, and in general, it results largely unsatisfactory. Factors responsible for this phenomenon include insufficient national cardiovascular healthcare policies for prevention, poor patient compliance with prescribed treatment schedules, and t...

journal_title：Circulation research

authors： Mancia G,Rea F,Corrao G,Grassi G

更新日期：2019-03-29 00:00:00

abstract：:Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

journal_title：Circulation research

authors： Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

更新日期：1984-03-01 00:00:00

abstract：:Apolipoprotein E-deficient (ApoE-/-) mice develop atherosclerotic lesions throughout the arterial tree, including the carotid bifurcation. Although the expression of adhesion molecules such as ICAM-1, vascular cell adhesion molecule-1 (VCAM-1), and P-selectin on endothelium that overlie atherosclerotic plaques has bee...

journal_title：Circulation research

authors： Ramos CL,Huo Y,Jung U,Ghosh S,Manka DR,Sarembock IJ,Ley K

更新日期：1999-06-11 00:00:00

abstract：RATIONALE:Mitochondria are key integrators of convergent intracellular signaling pathways. Two important second messengers modulated by mitochondria are calcium and reactive oxygen species. To date, coherent mechanisms describing mitochondrial integration of calcium and oxidative signaling in arterial smooth muscle are...

journal_title：Circulation research

authors： Chaplin NL,Nieves-Cintrón M,Fresquez AM,Navedo MF,Amberg GC

更新日期：2015-12-04 00:00:00

abstract：:Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of...

journal_title：Circulation research

authors： Tseng H,Peterson TE,Berk BC

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：:We examined whether albumin-derived advanced glycosylation end products (AGEs) downregulate the expression of endothelial nitric oxide synthase (NOS). Significant reductions in NOS activity and cGMP levels in bovine aortic endothelial cells were observed when exposed to different concentrations of albumin-derived AGEs...

journal_title：Circulation research

authors： Rojas A,Romay S,González D,Herrera B,Delgado R,Otero K

更新日期：2000-02-18 00:00:00

abstract：:The aim of this study was to determine the mechanism of action of norepinephrine (NE) on arterial baroreceptors (BRs), with the focus on regularly discharging, presumably myelinated fibers. With the use of an in vitro aortic arch/aortic nerve preparation from rats, BR single-fiber discharge was recorded simultaneously...

journal_title：Circulation research

authors： Munch PA,Thoren PN,Brown AM

更新日期：1987-09-01 00:00:00

abstract：RATIONALE:Myocardial infarction causes irreversible tissue damage, leading to heart failure. We recently discovered that canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse hearts after infarction. Wnt10b regulates cell fate in various organs, but its role in the heart is unknown. OBJECTIVE:To ...

journal_title：Circulation research

authors： Paik DT,Rai M,Ryzhov S,Sanders LN,Aisagbonhi O,Funke MJ,Feoktistov I,Hatzopoulos AK

更新日期：2015-10-09 00:00:00

abstract：RATIONALE:Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an endoplasmic reticulum (ER)-transmembrane E3 ubiquitin ligase that has been studied in yeast, where it contributes to ER protein quality control by ER-associated degradation (ERAD) of misfolded proteins that accumulate during ER str...

journal_title：Circulation research

authors： Doroudgar S,Völkers M,Thuerauf DJ,Khan M,Mohsin S,Respress JL,Wang W,Gude N,Müller OJ,Wehrens XH,Sussman MA,Glembotski CC

更新日期：2015-08-28 00:00:00

abstract：:To investigate the dynamic control of cardiac ATP synthesis, we simultaneously determined the time course of mitochondrial oxygen consumption with the time course of changes in high-energy phosphates following steps in cardiac energy demand. Isolated isovolumically contracting rabbit hearts were perfused with Tyrode's...

journal_title：Circulation research

authors： Eijgelshoven MH,van Beek JH,Mottet I,Nederhoff MG,van Echteld CJ,Westerhof N

更新日期：1994-10-01 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as dete...

journal_title：Circulation research

authors： Steinhelper ME

更新日期：1993-05-01 00:00:00

abstract：:Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled over the past decade supports a view that activation of the multifunctional Ca(2+) and calmodulin-dependent protein kina...

journal_title：Circulation research

authors： Swaminathan PD,Purohit A,Hund TJ,Anderson ME

更新日期：2012-06-08 00:00:00

abstract：:Successful implementation of local arterial drug delivery requires transmural distribution of drug. The physicochemical properties of the applied compound, which govern its transport and tissue binding, become as important as the mode of delivery. Hydrophilic compounds distribute freely but are cleared rapidly. Hydrop...

journal_title：Circulation research

authors： Creel CJ,Lovich MA,Edelman ER

更新日期：2000-04-28 00:00:00

abstract：RATIONALE:The embryonic epicardium is a crucial cell source of the cardiac fibrous skeleton as well as of the coronary system. Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse. OBJECTIVE:To define the adequacy of...

journal_title：Circulation research

authors： Rudat C,Kispert A

更新日期：2012-07-06 00:00:00

abstract：RATIONALE:Thousands of mutations across >50 genes have been implicated in inherited cardiomyopathies. However, options for sequencing this rapidly evolving gene set are limited because many sequencing services and off-the-shelf kits suffer from slow turnaround, inefficient capture of genomic DNA, and high cost. Further...

journal_title：Circulation research

authors： Wilson KD,Shen P,Fung E,Karakikes I,Zhang A,InanlooRahatloo K,Odegaard J,Sallam K,Davis RW,Lui GK,Ashley EA,Scharfe C,Wu JC

更新日期：2015-09-11 00:00:00

abstract：:Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and...

journal_title：Circulation research

authors： Wagner S,Maier LS,Bers DM

更新日期：2015-06-05 00:00:00

abstract：:Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac...

journal_title：Circulation research

authors： Perlman DH,Bauer SM,Ashrafian H,Bryan NS,Garcia-Saura MF,Lim CC,Fernandez BO,Infusini G,McComb ME,Costello CE,Feelisch M

更新日期：2009-03-27 00:00:00

abstract：:Isolated cardiac conduction disease is an autosomal dominant defect that includes various combinations of bundle branch or fascicular blocks. These defects can cause sudden death due to a complete heart block. We used a genome-wide screening approach with polymorphic (CA)n repeat markers to determine the chromosomal p...

journal_title：Circulation research

authors： de Meeus A,Stephan E,Debrus S,Jean MK,Loiselet J,Weissenbach J,Demaille J,Bouvagnet P

更新日期：1995-10-01 00:00:00

abstract：:Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8). In this study, we show that oxidized PAPC (OxPAPC), which accumulates in atheroscle...

journal_title：Circulation research

authors： Yeh M,Cole AL,Choi J,Liu Y,Tulchinsky D,Qiao JH,Fishbein MC,Dooley AN,Hovnanian T,Mouilleseaux K,Vora DK,Yang WP,Gargalovic P,Kirchgessner T,Shyy JY,Berliner JA

更新日期：2004-10-15 00:00:00

abstract：RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation. OBJECTIVE:We hypothesized that YAP activation after myocardial infarction (MI) would preserve cardiac function and improve survival. METHODS AND RESULTS:We use...

journal_title：Circulation research

authors： Lin Z,von Gise A,Zhou P,Gu F,Ma Q,Jiang J,Yau AL,Buck JN,Gouin KA,van Gorp PR,Zhou B,Chen J,Seidman JG,Wang DZ,Pu WT

更新日期：2014-07-18 00:00:00

abstract：RATIONALE:The peptide ligand apelin and its receptor APJ constitute a signaling pathway with numerous effects on the cardiovascular system, including cardiovascular development in model organisms such as xenopus and zebrafish. OBJECTIVE:This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice...

journal_title：Circulation research

authors： Kang Y,Kim J,Anderson JP,Wu J,Gleim SR,Kundu RK,McLean DL,Kim JD,Park H,Jin SW,Hwa J,Quertermous T,Chun HJ

更新日期：2013-06-21 00:00:00

abstract：:We examined the role of endogenous NO in the autonomic regulation of atrioventricular (AV) nodal function by studying spontaneous action potentials (SAPs) and L-type Ca2+ current (ICa-L) in isolated single AV nodal cells from adult rabbit hearts. Both the perforated and the membrane-ruptured patch-clamp techniques in ...

journal_title：Circulation research

authors： Han X,Kobzik L,Balligand JL,Kelly RA,Smith TW

更新日期：1996-06-01 00:00:00

abstract：:Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleot...

journal_title：Circulation research

authors： Omori K,Kotera J

更新日期：2007-02-16 00:00:00

abstract：:Twenty-one dogs were studied under conditions of normal oxygenation and hypoxia with the microsphere distribution method to determine the effect of arterial oxygen saturation on the regional distribution of cardiac output. The dogs were anesthetized and artifically ventilated. Cannulas were placed in the left ventricl...

journal_title：Circulation research

authors： Adachi H,Strauss W,Ochi H,Wagner HN Jr

更新日期：1976-09-01 00:00:00

abstract：:Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate, and intracellular pH, all measured by phosphorus-31 nuclear magnetic...

journal_title：Circulation research

authors： Hoerter JA,Miceli MV,Renlund DG,Jacobus WE,Gerstenblith G,Lakatta EG

更新日期：1986-04-01 00:00:00