Abstract:
:Blood pressure (BP) control in patients with hypertension is variable worldwide, and in general, it results largely unsatisfactory. Factors responsible for this phenomenon include insufficient national cardiovascular healthcare policies for prevention, poor patient compliance with prescribed treatment schedules, and the reluctance of physicians to modify treatment strategies when BP is still elevated, that is, the so-called therapeutic inertia. A further important factor favoring poor BP control is the limited use of combination drug treatment, despite evidence of its superior ability to control BP in patients with difficult-to-treat hypertension. In addition, combination treatment allows to achieve BP control more easily (and more quickly) as compared with monotherapy. This article, after briefly examining the main features of BP control, will review the importance in the treatment of hypertension of the drug combination strategy, based on the recommendations of the 2018 European Society of Cardiology/European Society of Hypertension guidelines. Empahsis will be given to the drug combination treatment as first step of the antihypertensive therapeutic intervention. The potential drawbacks and barriers to combination drug treatment as initial therapeutic strategy will also be briefly discussed.
journal_name
Circ Resjournal_title
Circulation researchauthors
Mancia G,Rea F,Corrao G,Grassi Gdoi
10.1161/CIRCRESAHA.118.313294subject
Has Abstractpub_date
2019-03-29 00:00:00pages
1113-1123issue
7eissn
0009-7330issn
1524-4571journal_volume
124pub_type
杂志文章,评审abstract::An animal model was used to test the hypothesis that in heart failure the decrease in the ability to resynthesize ATP through the creatine kinase (CK) reaction (which we call energy reserve) contributes to the inability of the heart to maintain its normal function and contractile reserve. One-week-old turkey poults we...
journal_title:Circulation research
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journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1983-10-01 00:00:00
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更新日期:1989-07-01 00:00:00
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doi:10.1161/01.res.56.4.486
更新日期:1985-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Circulation research
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