The oxygen sensitivity of hamster cheek pouch arterioles. In vitro and in situ studies.

abstract：:Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies...

journal_title：Circulation research

authors： Loyer X,Vion AC,Tedgui A,Boulanger CM

更新日期：2014-01-17 00:00:00

abstract：:To determine whether the attenuation in the growth capacity of myocytes in the overloaded aging heart is associated with an impairment in the activation of insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R) in the stressed cells, large myocardial infarcts were produced in Fischer 344 rats at 4 and 16 month...

journal_title：Circulation research

authors： Cheng W,Reiss K,Li P,Chun MJ,Kajstura J,Olivetti G,Anversa P

更新日期：1996-04-01 00:00:00

abstract：:We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect of TRPV1 on cytosol...

journal_title：Circulation research

authors： Zhang LL,Yan Liu D,Ma LQ,Luo ZD,Cao TB,Zhong J,Yan ZC,Wang LJ,Zhao ZG,Zhu SJ,Schrader M,Thilo F,Zhu ZM,Tepel M

更新日期：2007-04-13 00:00:00

abstract：RATIONALE:The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined structures including central components and a peripheral Purkinje fiber network. How the mammalian ven...

journal_title：Circulation research

authors： Miquerol L,Moreno-Rascon N,Beyer S,Dupays L,Meilhac SM,Buckingham ME,Franco D,Kelly RG

更新日期：2010-07-09 00:00:00

abstract：:The influence that the pressure-sensitive receptors in the cardiovascular system have on renal nerve activity and on heart rate was compared in normotensive rats (NTR) and spontaneously hypertensive rats (SHR). The cardiovascular receptors were stimulated by raising the blood pressure (BP) with intravenous phenylephri...

journal_title：Circulation research

authors： Coote JH,Sato Y

更新日期：1977-06-01 00:00:00

abstract：:Cardiomyocyte hypertrophy is transcriptionally controlled and inhibited by glycogen synthase kinase 3beta (GSK3beta). Myocardin is a muscle-specific transcription factor with yet unknown relation to hypertrophy. Therefore, we investigated whether myocardin is sufficient to induce cardiomyocyte hypertrophy and whether ...

journal_title：Circulation research

authors： Badorff C,Seeger FH,Zeiher AM,Dimmeler S

更新日期：2005-09-30 00:00:00

abstract：:The introduction of statins ≈ 30 years ago ushered in the era of lipid lowering as the most effective way to reduce risk of atherosclerotic cardiovascular disease. Nonetheless, residual risk remains high, and statin intolerance is frequently encountered in clinical practice. After a long dry period, the field of thera...

journal_title：Circulation research

authors： Shapiro MD,Fazio S

更新日期：2016-02-19 00:00:00

abstract：:Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in dramatic changes in the release of adipokines, such as leptin and adiponectin, both of which have emerged as important regulators of car...

journal_title：Circulation research

authors： Lopaschuk GD,Folmes CD,Stanley WC

更新日期：2007-08-17 00:00:00

abstract：:The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium i...

journal_title：Circulation research

authors： Schiebinger RJ

更新日期：1989-09-01 00:00:00

abstract：RATIONALE:Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during a...

journal_title：Circulation research

authors： Kim K,Shim D,Lee JS,Zaitsev K,Williams JW,Kim KW,Jang MY,Seok Jang H,Yun TJ,Lee SH,Yoon WK,Prat A,Seidah NG,Choi J,Lee SP,Yoon SH,Nam JW,Seong JK,Oh GT,Randolph GJ,Artyomov MN,Cheong C,Choi JH

更新日期：2018-10-26 00:00:00

abstract：:We examined the role of endogenous NO in the autonomic regulation of atrioventricular (AV) nodal function by studying spontaneous action potentials (SAPs) and L-type Ca2+ current (ICa-L) in isolated single AV nodal cells from adult rabbit hearts. Both the perforated and the membrane-ruptured patch-clamp techniques in ...

journal_title：Circulation research

authors： Han X,Kobzik L,Balligand JL,Kelly RA,Smith TW

更新日期：1996-06-01 00:00:00

abstract：:14-3-3 family members are dimeric phosphoserine-binding proteins that regulate signal transduction, apoptotic, and checkpoint control pathways. Targeted expression of dominant-negative 14-3-3eta (DN-14-3-3) to murine postnatal cardiac tissue potentiates Ask1, c-jun N-terminal kinase (JNK), and p38 mitogen-activated pr...

journal_title：Circulation research

authors： Zhang S,Ren J,Zhang CE,Treskov I,Wang Y,Muslin AJ

更新日期：2003-11-28 00:00:00

abstract：RATIONALE:We have shown recently that particulate (pGC) and soluble guanylyl (sGC) cyclases synthesize cGMP in different compartments in adult rat ventricular myocytes (ARVMs). OBJECTIVE:We hypothesized that cGMP-dependent protein kinase (PKG) exerts a feedback control on cGMP concentration contributing to its intrace...

journal_title：Circulation research

authors： Castro LR,Schittl J,Fischmeister R

更新日期：2010-11-12 00:00:00

abstract：:The small (21 kDa) guanine nucleotide-binding protein (small G protein) superfamily comprises 5 subfamilies (Ras, Rho, ADP ribosylation factors [ARFs], Rab, and Ran) that act as molecular switches to regulate numerous cellular responses. Cardiac myocyte hypertrophy is associated with cell growth and changes in the cyt...

journal_title：Circulation research

authors： Clerk A,Sugden PH

更新日期：2000-05-26 00:00:00

abstract：:Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reduction...

journal_title：Circulation research

authors： Hasegawa K,Wakino S,Tatematsu S,Yoshioka K,Homma K,Sugano N,Kimoto M,Hayashi K,Itoh H

更新日期：2007-07-20 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：RATIONALE:Increased sympathetic nerve activity has been linked to the pathogenesis of hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity which increases sympathetic nerve activity has been observed in established hypertension but has not been identified as a possible mechanism for i...

journal_title：Circulation research

authors： Tan ZY,Lu Y,Whiteis CA,Simms AE,Paton JF,Chapleau MW,Abboud FM

更新日期：2010-02-19 00:00:00

abstract：:We have shown previously that tyrosine 319 in a conserved YIPP motif in the C terminus of angiotensin II (Ang II) type 1 receptors (AT(1)Rs) is essential for transactivation of epidermal growth factor receptor (EGFR) in vitro. We hypothesized that the signaling mechanism mediated through the specific amino acid sequen...

journal_title：Circulation research

authors： Zhai P,Galeotti J,Liu J,Holle E,Yu X,Wagner T,Sadoshima J

更新日期：2006-09-01 00:00:00

abstract：:This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are dis...

journal_title：Circulation research

authors： Li JK,Melbin J,Riffle RA,Noordergraaf A

更新日期：1981-08-01 00:00:00

abstract：:Triadin 1 (TRD) is an integral membrane protein that associates with the ryanodine receptor (RyR2), calsequestrin (CASQ2) and junctin to form a macromolecular Ca signaling complex in the cardiac junctional sarcoplasmic reticulum (SR). To define the functional role of TRD, we examined the effects of adenoviral-mediated...

journal_title：Circulation research

authors： Terentyev D,Cala SE,Houle TD,Viatchenko-Karpinski S,Gyorke I,Terentyeva R,Williams SC,Gyorke S

更新日期：2005-04-01 00:00:00

abstract：:The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypert...

journal_title：Circulation research

authors： Shirakabe A,Ikeda Y,Sciarretta S,Zablocki DK,Sadoshima J

更新日期：2016-05-13 00:00:00

abstract：RATIONALE:Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor. However, there is lack of experimental evidence. OBJECTIVE:In this study, we investigated inflammation-associated stroke using a mouse model that ...

journal_title：Circulation research

authors： Hollander MC,Latour LL,Yang D,Ishii H,Xiao Z,Min Y,Ray-Choudhury A,Munasinghe J,Merchant AS,Lin PC,Hallenbeck J,Boehm M,Yang L

更新日期：2017-12-08 00:00:00

abstract：:Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to b...

journal_title：Circulation research

authors： Weinstock A,Moura Silva H,Moore KJ,Schmidt AM,Fisher EA

更新日期：2020-05-22 00:00:00

abstract：:Nuclear factor kappa B (NF-kappaB) participates in hypertension-induced vascular and target-organ damage. We tested whether or not endothelial cell-specific NF-kappaB suppression would be ameliorative. We generated Cre/lox transgenic mice with endothelial cell-restricted NF-kappaB super-repressor IkappaBalphaDeltaN (T...

journal_title：Circulation research

authors： Henke N,Schmidt-Ullrich R,Dechend R,Park JK,Qadri F,Wellner M,Obst M,Gross V,Dietz R,Luft FC,Scheidereit C,Muller DN

更新日期：2007-08-03 00:00:00

abstract：:To study whether atrial fibrillation might produce local changes in the atrium which could facilitate the tendency of this arrhythmia to become chronic and self-perpetuating, we compared the effect of atrial fibrillation, atrial pacing, and acute volume loading on the perfusion and oxygen consumption of the atrium in ...

journal_title：Circulation research

authors： White CW,Kerber RE,Weiss HR,Marcus ML

更新日期：1982-08-01 00:00:00

abstract：:Heart failure (HF) has been singled out as an epidemic and is a staggering clinical and public health problem, associated with significant mortality, morbidity, and healthcare expenditures, particularly among those aged ≥ 65 years. The case mix of HF is changing over time with a growing proportion of cases presenting ...

journal_title：Circulation research

authors： Roger VL

更新日期：2013-08-30 00:00:00

abstract：:Abnormal mechanical forces can trigger aberrant proliferation of endothelial and smooth muscle cells, as observed in the progression of vascular diseases such as atherosclerosis. It has been previously shown that cells can sense physical forces such as stretch through adhesions to the extracellular matrix. Here, we se...

journal_title：Circulation research

authors： Liu WF,Nelson CM,Tan JL,Chen CS

更新日期：2007-08-31 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00

abstract：:During periodic stimulation of spontaneously beating chick heart cell aggregates, there is often an evolution of coupling patterns between the stimulator and the aggregate action potential. For example, at rapid stimulation frequencies, a rhythm that is initially 1:1 (stimulus frequency:aggregate frequency) can evolve...

journal_title：Circulation research

authors： Zeng WZ,Glass L,Shrier A

更新日期：1991-10-01 00:00:00

abstract：:Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whethe...

journal_title：Circulation research

authors： Verschuren L,Kooistra T,Bernhagen J,Voshol PJ,Ouwens DM,van Erk M,de Vries-van der Weij J,Leng L,van Bockel JH,van Dijk KW,Fingerle-Rowson G,Bucala R,Kleemann R

更新日期：2009-07-02 00:00:00