Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

abstract：:Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encoding proteins (MCIP1 and MCIP...

journal_title：Circulation research

authors： Yang J,Rothermel B,Vega RB,Frey N,McKinsey TA,Olson EN,Bassel-Duby R,Williams RS

更新日期：2000-12-08 00:00:00

abstract：:To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening using RNA from cultured rat aortic VSMCs. The tissue specificity of expression of all of the cDNAs isolated was determined by Northern analysis. We isolated se...

journal_title：Circulation research

authors： Shanahan CM,Weissberg PL,Metcalfe JC

更新日期：1993-07-01 00:00:00

abstract：:Cyclic GMP (cGMP) kinase is intimately involved in the regulation of vascular smooth muscle tone. Its tissue concentration was determined in normotensive and hypertensive rats by use of monospecific anti-cGMP kinase antibodies. Hearts of spontaneously hypertensive rats and renovascular (Goldblatt II) hypertensive rats...

journal_title：Circulation research

authors： Ecker T,Göbel C,Hullin R,Rettig R,Seitz G,Hofmann F

更新日期：1989-11-01 00:00:00

abstract：:Endothelial cells, either in vivo or freshly isolated, respond when exposed to muscarinic agonists with an increase in cytosolic free calcium concentration ([Ca2+]i) and release of endothelium-derived relaxing factor (EDRF). When placed in culture, however, endothelial cells rapidly lose these responses, which may be ...

journal_title：Circulation research

authors： Tracey WR,Peach MJ

更新日期：1992-02-01 00:00:00

abstract：:The adenosine analogue phenylisopropyladenosine decreased the basal and isoproterenol-stimulated contractile state of isolated rat left atria. The ED50 levels for both responses were similar, suggesting that direct and antiadrenergic effects may be mediated by the same receptor. Phenylisopropyladenosine decreased the ...

journal_title：Circulation research

authors： Linden J,Hollen CE,Patel A

更新日期：1985-05-01 00:00:00

abstract：:Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link is yet established between the vascular pathology of the metabolic syndrome with a particular inflammatory cytokine. We hypothesized that impairments in coronary endothelial function in the obese...

journal_title：Circulation research

authors： Picchi A,Gao X,Belmadani S,Potter BJ,Focardi M,Chilian WM,Zhang C

更新日期：2006-07-07 00:00:00

abstract：:Gap junction pharmacology is a nascent field. Previous studies have identified molecules that enhance intercellular communication, and may offer potential for innovative antiarrhythmic therapy. However, their specific molecular target(s) and mechanism(s) of action remain unknown. Previously, we identified a 34-aa pept...

journal_title：Circulation research

authors： Verma V,Larsen BD,Coombs W,Lin X,Spagnol G,Sorgen PL,Taffet SM,Delmar M

更新日期：2009-07-17 00:00:00

abstract：:Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and int...

journal_title：Circulation research

authors： Kaneko T,Tanaka H,Oyamada M,Kawata S,Takamatsu T

更新日期：2000-05-26 00:00:00

abstract：:We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of beta-catenin. In this study we demonstrate directly that growth factors stimulate beta-catenin/T-cell factor (TCF) signaling ...

journal_title：Circulation research

authors： Quasnichka H,Slater SC,Beeching CA,Boehm M,Sala-Newby GB,George SJ

更新日期：2006-12-08 00:00:00

abstract：:We studied the pulmonary vascular effects of prostacylin, PGI2, in the cat with intact chest under conditions of controlled blood flow. Intralobar injections of PGI2, 0.03--1 microgram, decreased arterial pressure in the perfused lobe in a dose-dependent manner. Inasmuch as lobar blood flow was held constant and left ...

journal_title：Circulation research

authors： Hyman AL,Kadowitz PJ

更新日期：1979-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...

journal_title：Circulation research

authors： Kim CH,Cho YS,Chun YS,Park JW,Kim MS

更新日期：2002-02-08 00:00:00

abstract：:To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and ...

journal_title：Circulation research

authors： Nagasawa K,Tomoike H,Hayashi Y,Yamada A,Yamamoto T,Nakamura M

更新日期：1989-08-01 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：:Postischemic endothelial dysfunction may occur as a result of the effects of endogenous oxidants like hydrogen peroxide. Since endothelium-dependent vasodilator function may be affected by pHi, the effect of hydrogen peroxide on endothelial pHi was examined. Hydrogen peroxide (100 micromol/L for 10 minutes) decreased ...

journal_title：Circulation research

authors： Hu Q,Xia Y,Corda S,Zweier JL,Ziegelstein RC

更新日期：1998-09-21 00:00:00

abstract：:The present study was performed to examine the mechanism by which cyclooxygenase blockade produces vasoconstriction in well-developed coronary collateral vessels. Eight dogs were studied 4 to 6 months after occlusion of the left anterior descending coronary artery (LAD) had been performed to stimulate collateral vesse...

journal_title：Circulation research

authors： Altman JD,Bache RJ

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Flecainide, a class 1c antiarrhythmic, has emerged as an effective therapy in preventing arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) refractory to β-adrenergic receptor blockade. It has been proposed that the clinical efficacy of flecainide in CPVT is because of t...

journal_title：Circulation research

authors： Bannister ML,Thomas NL,Sikkel MB,Mukherjee S,Maxwell C,MacLeod KT,George CH,Williams AJ

更新日期：2015-04-10 00:00:00

abstract：:The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v. +1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p less than 0.02) and decreased renal blood flow by 71% and glomerular filtrat...

journal_title：Circulation research

authors： Hirata Y,Matsuoka H,Kimura K,Fukui K,Hayakawa H,Suzuki E,Sugimoto T,Sugimoto T,Yanagisawa M,Masaki T

更新日期：1989-11-01 00:00:00

abstract：:The use of risk markers has transformed cardiovascular medicine, exemplified by the routine assessment of troponin, for both diagnosis and assessment of prognosis in patients with chest pain. Clinical risk factors form the basis for risk assessment of cardiovascular disease and the addition of biochemical, cellular, a...

journal_title：Circulation research

authors： Thomas MR,Lip GY

更新日期：2017-01-06 00:00:00

abstract：:Cells with endothelial phenotype generated from adult peripheral blood have emerging diagnostic and therapeutic potential. This study examined the lineage relationship between, and angiogenic function of, early endothelial progenitor cells (EPCs) and late outgrowth endothelial cells (OECs) in culture. Culture conditio...

journal_title：Circulation research

authors： Gulati R,Jevremovic D,Peterson TE,Chatterjee S,Shah V,Vile RG,Simari RD

更新日期：2003-11-28 00:00:00

abstract：:Clonidine and related drugs cause a specific pattern of cardiovascular depression by an agonistic effect on alpha-adrenoceptors within the central nervous system (CNS). For further characterization of the central adrenoceptors, the actions of three substances of the "clonidine-type" derived from two different chemical...

journal_title：Circulation research

authors： Kobinger W,Lillie C,Pichler L

更新日期：1980-06-01 00:00:00

abstract：RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...

journal_title：Circulation research

authors： Glessner JT,Bick AG,Ito K,Homsy J,Rodriguez-Murillo L,Fromer M,Mazaika E,Vardarajan B,Italia M,Leipzig J,DePalma SR,Golhar R,Sanders SJ,Yamrom B,Ronemus M,Iossifov I,Willsey AJ,State MW,Kaltman JR,White PS,Shen Y

更新日期：2014-10-24 00:00:00

abstract：RATIONALE:Mutations in vascular endothelial growth factor (VEGF) receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients with classic Milroy disease, suggesting genetic heterogeneity. OBJECTIV...

journal_title：Circulation research

authors： Gordon K,Schulte D,Brice G,Simpson MA,Roukens MG,van Impel A,Connell F,Kalidas K,Jeffery S,Mortimer PS,Mansour S,Schulte-Merker S,Ostergaard P

更新日期：2013-03-15 00:00:00

abstract：:We used a genetic approach to determine whether increasing the level of A3 adenosine receptors (A3ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A3tg.1) or six (A3tg.6) copies of a transgene consisting of the cardiomyocyte-specific alp...

journal_title：Circulation research

authors： Black RG Jr,Guo Y,Ge ZD,Murphree SS,Prabhu SD,Jones WK,Bolli R,Auchampach JA

更新日期：2002-07-26 00:00:00

abstract：:The present experiments were performed to investigate whether neurogenic inflammation in rat trachea (with edema formation and protein extravasation when the circulation is intact) induced by electrical field stimulation of neuropeptide-containing C fibers in the vagal nerve is accompanied by increased negativity of i...

journal_title：Circulation research

authors： Woie K,Koller ME,Heyeraas KJ,Reed RK

更新日期：1993-11-01 00:00:00

abstract：:[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrene...

journal_title：Circulation research

authors： Manalan AS,Besch HR Jr,Watanabe AM

更新日期：1981-08-01 00:00:00

abstract：:This study investigated the possible roles of strongly binding myosin crossbridges in determining loaded shortening and power output in cardiac myocytes. Single skinned cardiac myocytes were attached between a force transducer and position motor, and shortening velocities were measured over a range of loads during var...

journal_title：Circulation research

authors： McDonald KS,Moss RL

更新日期：2000-10-27 00:00:00

abstract：:This paper describes use of the Karhunen-Loeve expansion to identify and reduce temporal redundancy in electrocardiographic body surface potential maps (192 body surface leads recorded simultaneously at 1 kHz/channel for approximately 600 msec). Temporal data compression of about 20 to 1 was obtained with accurate rep...

journal_title：Circulation research

authors： Evans AK,Lux RL,Burgess MJ,Wyatt RF,Abildskov JA

更新日期：1981-07-01 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accura...

journal_title：Circulation research

authors： Griendling KK,Touyz RM,Zweier JL,Dikalov S,Chilian W,Chen YR,Harrison DG,Bhatnagar A,American Heart Association Council on Basic Cardiovascular Sciences.

更新日期：2016-08-19 00:00:00

abstract：RATIONALE:Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration because of the fact that all GSK-3-targeted drugs, ...

journal_title：Circulation research

authors： Zhou J,Ahmad F,Parikh S,Hoffman NE,Rajan S,Verma VK,Song J,Yuan A,Shanmughapriya S,Guo Y,Gao E,Koch W,Woodgett JR,Madesh M,Kishore R,Lal H,Force T

更新日期：2016-04-15 00:00:00

abstract：:Bone marrow-derived cells (BMCs) have been implicated as a modifiers of vascular growth either directly by transdifferentiation into endothelial cells (ECs) or indirectly through growth factor release. To examine these possibilities under physiological conditions, we developed a model of hypoxia-mediated angiogenesis ...

journal_title：Circulation research

authors： O'Neill TJ 4th,Wamhoff BR,Owens GK,Skalak TC

更新日期：2005-11-11 00:00:00