Structure, expression, and genomic mapping of the mouse natriuretic peptide type-B gene.

abstract：:Inflammatory cell infiltration is a feature of postischemic neovascularization. However, mechanisms leading to leukocyte attraction to the site of neovascularization are still undefined. We hypothesized that the CXC chemokine receptor 3 (CXCR3) may contribute to leukocyte accumulation and subsequently to blood vessel ...

journal_title：Circulation research

authors： Waeckel L,Mallat Z,Potteaux S,Combadière C,Clergue M,Duriez M,Bao L,Gerard C,Rollins BJ,Tedgui A,Levy BI,Silvestre JS

更新日期：2005-03-18 00:00:00

abstract：:In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

journal_title：Circulation research

authors： Tohse N,Mészáros J,Sperelakis N

更新日期：1992-08-01 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

journal_title：Circulation research

authors： Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

更新日期：1977-08-01 00:00:00

abstract：RATIONALE:The activation of the Smad2 signaling pathway is thought to play an important role in human aneurysmal diseases as described by an important body of research. We previously showed that constitutive Smad2 activation is associated with Smad2 mRNA overexpression in aneurysmal vascular smooth muscle cells (VSMCs)...

journal_title：Circulation research

authors： Gomez D,Kessler K,Michel JB,Vranckx R

更新日期：2013-09-13 00:00:00

abstract：:Cellular mechanisms underlying beta-adrenergic stimulation of the arrhythmogenic transient inward current (TI) were investigated by using a two-microelectrode voltage-clamp technique in rabbit cardiac Purkinje fibers. TI induced by elevating [Ca2+]o to 30 mmol/L and substituting [Na+]o with N-methyl-D-glucamine (NMG) ...

journal_title：Circulation research

authors： Han X,Ferrier GR

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:ASK1-interacting protein-1 (AIP1), a Ras GTPase-activating protein family member, is highly expressed in endothelial cells and vascular smooth musccells (VSMCs). The role of AIP1 in VSMCs and VSMC proliferative disease is not known. OBJECTIVE:We used mouse graft arteriosclerosis models characterized by VSMC ...

journal_title：Circulation research

authors： Yu L,Qin L,Zhang H,He Y,Chen H,Pober JS,Tellides G,Min W

更新日期：2011-08-05 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoyl phorbol-13-acetate was used to probe the role of protein kinase-C in the modulation of alpha-adrenergic receptor-coupled calcium efflux in cultured vascular smooth muscle cells derived from rabbit aorta. Exposure of cells to 12-O-tetradecanoyl phorbol-13-acetate for 6 minutes cause...

journal_title：Circulation research

authors： Colucci WS,Gimbrone MA Jr,Alexander RW

更新日期：1986-03-01 00:00:00

abstract：:Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable technique...

journal_title：Circulation research

authors： van Rooij E

更新日期：2011-01-21 00:00:00

abstract：:We studied the specificity of uptake of infarct-imaging agents for reversibly or irreversibly injured myocardium independently of blood flow by using intact beating fetal mouse hearts in organ culture. Reversible injury resulted from deprivation of oxygen and glucose for 4 hours at 37 degrees C; irreversible injury, f...

journal_title：Circulation research

authors： Schelbert HR,Ingwall JS,Sybers HD,Ashburn WL

更新日期：1976-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...

journal_title：Circulation research

authors： Kim CH,Cho YS,Chun YS,Park JW,Kim MS

更新日期：2002-02-08 00:00:00

abstract：:Reductions in fluid shear stress produce endothelium-dependent vasoconstriction and promote neointimal hyperplasia, but the intracellular signaling mechanisms involved in these processes are poorly understood. To examine whether decreases in fluid shear stress affect endothelial cytosolic pH, carboxy-seminaphthorhodaf...

journal_title：Circulation research

authors： Ziegelstein RC,Blank PS,Cheng L,Capogrossi MC

更新日期：1998-04-20 00:00:00

abstract：:Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggest...

journal_title：Circulation research

authors： Gkaliagkousi E,Ritter J,Ferro A

更新日期：2007-09-28 00:00:00

abstract：:Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action pot...

journal_title：Circulation research

authors： Mitsuiye T,Shinagawa Y,Noma A

更新日期：2000-07-21 00:00:00

abstract：RATIONALE:Mechanical stress plays an important role in proliferation of venous smooth muscle cells (SMCs) in neointima, a process of formation that contributes to failure of vein grafts. However, it is unknown what intracellular growth signal leads to proliferation of venous SMCs. OBJECTIVE:The objective of this study...

journal_title：Circulation research

authors： Cheng J,Wang Y,Ma Y,Chan BT,Yang M,Liang A,Zhang L,Li H,Du J

更新日期：2010-11-12 00:00:00

abstract：RATIONALE:We previously reported that type VI collagen deposition increases in the infarcted myocardium in vivo. To date, a specific role for this nonfibrillar collagen has not been explored in the setting of myocardial infarction (MI). OBJECTIVE:To determine whether deletion of type VI collagen in an in vivo model of...

journal_title：Circulation research

authors： Luther DJ,Thodeti CK,Shamhart PE,Adapala RK,Hodnichak C,Weihrauch D,Bonaldo P,Chilian WM,Meszaros JG

更新日期：2012-03-16 00:00:00

abstract：:A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase calcineurin as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in left ventricular hypertrophy (LVH). Most of the recent experimental support for this hypothesis is derived fro...

journal_title：Circulation research

authors： Zhang W,Kowal RC,Rusnak F,Sikkink RA,Olson EN,Victor RG

更新日期：1999-04-02 00:00:00

abstract：:We studied the mechanisms underlying the increase in automaticity induced by alpha 1-adrenergic stimulation of normal and "ischemic" canine Purkinje fibers. Fibers were superfused with a control Tyrode's solution, followed by an ischemic superfusate that included 10 mM KCl, 5 mM NaHCO3, Po2 of 10-25 mm Hg, and pH 6.7....

journal_title：Circulation research

authors： Anyukhovsky EP,Rybin VO,Nikashin AV,Budanova OP,Rosen MR

更新日期：1992-09-01 00:00:00

abstract：:In patients with congestive heart failure, skeletal muscle is characterized by a smaller proportion of slow-twitch oxidative fibers and reduced oxidative enzyme activity. However, whether these changes result from disuse or occur as a direct consequence of heart failure is unresolved. To address this issue, 18 rats wi...

journal_title：Circulation research

authors： Simonini A,Long CS,Dudley GA,Yue P,McElhinny J,Massie BM

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:G protein-coupled receptor kinase 2 (GRK2) is abundantly expressed in the heart, and its expression and activity are increased in injured or stressed myocardium. This upregulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes, and its inhibition by a peptide comprising th...

journal_title：Circulation research

authors： Chen M,Sato PY,Chuprun JK,Peroutka RJ,Otis NJ,Ibetti J,Pan S,Sheu SS,Gao E,Koch WJ

更新日期：2013-04-12 00:00:00

abstract：RATIONALE:Although tyrosine kinases (TKs) are important for cardiac function, their relevant downstream targets in the adult heart are unknown. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal pTyr-binding (PTB) and C-terminal SH2 domains and stimulates downst...

journal_title：Circulation research

authors： Vanderlaan RD,Hardy WR,Kabir MG,Pasculescu A,Jones N,deTombe PP,Backx PH,Pawson T

更新日期：2011-01-21 00:00:00

abstract：BACKGROUND:Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation. OBJE...

journal_title：Circulation research

authors： Lancel S,Qin F,Lennon SL,Zhang J,Tong X,Mazzini MJ,Kang YJ,Siwik DA,Cohen RA,Colucci WS

更新日期：2010-07-23 00:00:00

abstract：:The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypert...

journal_title：Circulation research

authors： Shirakabe A,Ikeda Y,Sciarretta S,Zablocki DK,Sadoshima J

更新日期：2016-05-13 00:00:00

abstract：RATIONALE:Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during a...

journal_title：Circulation research

authors： Kim K,Shim D,Lee JS,Zaitsev K,Williams JW,Kim KW,Jang MY,Seok Jang H,Yun TJ,Lee SH,Yoon WK,Prat A,Seidah NG,Choi J,Lee SP,Yoon SH,Nam JW,Seong JK,Oh GT,Randolph GJ,Artyomov MN,Cheong C,Choi JH

更新日期：2018-10-26 00:00:00

abstract：:Using alpha-chloralose-anesthetized cats, we studied blood pressure and heart rate responses to static contraction and passive stretch of the triceps surae muscle before and after microdialyzing the mu-opioid agonist [D-Ala2]-methionine enkephalinamide (DAME, 200 mumol/L) into the L-7 dorsal horn of the spinal cord. I...

journal_title：Circulation research

authors： Meintjes AF,Nóbrega AC,Fuchs IE,Ally A,Wilson LB

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation. OBJECTIVE:We hypothesized that YAP activation after myocardial infarction (MI) would preserve cardiac function and improve survival. METHODS AND RESULTS:We use...

journal_title：Circulation research

authors： Lin Z,von Gise A,Zhou P,Gu F,Ma Q,Jiang J,Yau AL,Buck JN,Gouin KA,van Gorp PR,Zhou B,Chen J,Seidman JG,Wang DZ,Pu WT

更新日期：2014-07-18 00:00:00

abstract：:Bone marrow-derived cells (BMCs) have been implicated as a modifiers of vascular growth either directly by transdifferentiation into endothelial cells (ECs) or indirectly through growth factor release. To examine these possibilities under physiological conditions, we developed a model of hypoxia-mediated angiogenesis ...

journal_title：Circulation research

authors： O'Neill TJ 4th,Wamhoff BR,Owens GK,Skalak TC

更新日期：2005-11-11 00:00:00

abstract：:Cyclic GMP modulates gene expression in vascular smooth muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphorylation of transcription factors. In some cells, cGMP increases nuclear translocation of PKGI and PKGI-dependent phosphorylation of transcription regulators; however...

journal_title：Circulation research

authors： Sugiura T,Nakanishi H,Roberts JD Jr

更新日期：2008-07-03 00:00:00

abstract：:Of 145 patients with borderline hypertension, 30% had increased resting cardiac index (QI), whereas the remainder had normal values. The specific aim of this study was to investigate cardiac regulation in patients who had normal resting QI. Eighty-five control subjects were used for comparison. At rest, patients with ...

journal_title：Circulation research

authors： Julius S,Randall OS,Esler MD,Kashima T,Ellis C,Bennett J

更新日期：1975-06-01 00:00:00