Abstract:
:The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. Responses to nerve stimulation were decreased to a greater extent than responses to norepinephrine. At lower concentrations the effects of PGE2 on pressor responses and on vascular resistance could be separated. Reserpine decreased the histochemical evidence of adrenergic innervation and reduced the response to renal nerve stimulation, enhanced the response to norepinephrine, and was without effect on the response to angiotensin. Indomethacin decreased depressor responses to arachidonic acid, produced a small increase in renal vascular resistance but did not enhance renal pressor responses. The increase in renal vascular resistance after indomethacin was not modified by reserpine pretreatment. Indomethacin enhanced the renal response to bradykinin. These data show that PGE2 possesses the ability to modulate pressor responses in the kidney. However, experiments with indomethacin suggest that endogenous prostaglandins neither modulate pressor responses nor mediate the response of the renal vascular bed to bradykinin. In addition, these data suggest that the increase in renal resistance after indomethacin is not dependent on the adrenergic nervous system.
journal_name
Circ Resjournal_title
Circulation researchauthors
Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJdoi
10.1161/01.res.41.2.172subject
Has Abstractpub_date
1977-08-01 00:00:00pages
172-8issue
2eissn
0009-7330issn
1524-4571journal_volume
41pub_type
杂志文章abstract:RATIONALE:Slow nonuniform electric propagation in the border zone (BZ) of a healed myocardial infarct (MI) can give rise to reentrant arrhythmia. The extent to which this is influenced by structural rather than cellular electric remodeling is unclear. OBJECTIVE:To determine whether structural remodeling alone in the i...
journal_title:Circulation research
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更新日期:2012-07-20 00:00:00
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pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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更新日期:1981-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-16 00:00:00
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1989-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-01-18 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.63.1.267
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.85.12.1139
更新日期:1999-12-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.86.3.e50
更新日期:2000-02-18 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000091260.78959.BC
更新日期:2003-09-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.119.315786
更新日期:2019-10-25 00:00:00
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pub_type: 杂志文章
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更新日期:2007-07-20 00:00:00
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更新日期:2018-12-07 00:00:00
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pub_type: 杂志文章
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更新日期:2004-10-15 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.77.4.735
更新日期:1995-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-03-30 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-28 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.36.1.58
更新日期:1975-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1975-07-01 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:1981-02-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.120.317950
更新日期:2020-12-04 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2004-05-28 00:00:00