Abstract:
:We have investigated the actions of vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) on the pacemaker current (I(f)) in canine Purkinje fibers. On voltage pulses to the middle of the I(f) activation range, VIP reversibly increases I(f), whereas NPY reversibly decreases I(f). A three-pulse voltage protocol suggests that VIP shifts I(f) activation in the positive direction and that NPY shifts I(f) activation in the negative direction on the voltage axis without changing maximal I(f) conductance. These effects of VIP and NPY on I(f) are exerted through their specific peptide receptors, since the effects are blocked by VIP and NPY receptor antagonists. VIP and NPY are colocalized in cardiac parasympathetic and sympathetic nerve endings, respectively, and can be released preferentially on high and long-lasting nerve stimulation. Given this colocalization and frequency-dependent release, these results suggest a role for these neuropeptides in controlling cardiac I(f) and consequently heart rate.
journal_name
Circ Resjournal_title
Circulation researchauthors
Chang F,Yu H,Cohen ISdoi
10.1161/01.res.74.1.157subject
Has Abstractpub_date
1994-01-01 00:00:00pages
157-62issue
1eissn
0009-7330issn
1524-4571journal_volume
74pub_type
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
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更新日期:2021-01-08 00:00:00
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更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-10-17 00:00:00
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更新日期:1980-01-01 00:00:00
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更新日期:2009-07-31 00:00:00
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pub_type: 杂志文章
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更新日期:2003-11-28 00:00:00
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pub_type: 杂志文章
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更新日期:1976-07-01 00:00:00
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更新日期:1988-07-01 00:00:00
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更新日期:2007-12-07 00:00:00
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更新日期:1981-08-01 00:00:00
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更新日期:1999-10-15 00:00:00
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更新日期:1990-04-01 00:00:00
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更新日期:2006-09-29 00:00:00