Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.

abstract：:This study aimed to characterize the interaction between nitric oxide (NO)- and cAMP-related pathways in the control of renal blood flow. Using the isolated perfused rat kidney model, we determined the effects of inhibition of NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME; 1 mmol/L) and of NO administra...

journal_title：Circulation research

authors： Sandner P,Kornfeld M,Ruan X,Arendshorst WJ,Kurtz A

更新日期：1999-02-05 00:00:00

abstract：:Three models of altered autonomic innervation of the chick heart have been developed in the last few years. These include sympathetically aneural heart, parasympathetically aneural heart, and heart with cholinergic innervation reconstituted from the nodose placodes. The neural status of these hearts has been assessed ...

journal_title：Circulation research

authors： Kirby ML,Creazzo TL,Christiansen JL

更新日期：1989-12-01 00:00:00

abstract：:We studied the effects of slow continuous hemorrhage (0.5 ml/kg per min) on measurements of arterial and left atrial pressures, and renal nerve activity in conscious dogs with all reflexes intact, or after sinoaortic baroreceptor denervation, cardiac denervation, or sinoaortic baroreceptor denervation plus vagal dener...

journal_title：Circulation research

authors： Morita H,Vatner SF

更新日期：1985-11-01 00:00:00

abstract：:The purpose of this study was to determine whether a cyclic adenosine 3',5'-monophosphate-dependent process can be involved in the regulation of vascular smooth muscle alpha 1-adrenergic receptor responsiveness. Experiments were performed in cultured rabbit aortic smooth muscle cells which were characterized previousl...

journal_title：Circulation research

authors： Colucci WS

更新日期：1986-02-01 00:00:00

abstract：RATIONALE:Allogeneic mesenchymal precursor cells (MPCs) have been effective in large animal models of ischemic and nonischemic heart failure (HF). OBJECTIVE:To evaluate the feasibility and safety of 3 doses (25, 75, or 150 million cells) of immunoselected allogeneic MPCs in chronic HF patients in a phase 2 trial. MET...

journal_title：Circulation research

authors： Perin EC,Borow KM,Silva GV,DeMaria AN,Marroquin OC,Huang PP,Traverse JH,Krum H,Skerrett D,Zheng Y,Willerson JT,Itescu S,Henry TD

更新日期：2015-08-28 00:00:00

abstract：:Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogeno...

journal_title：Circulation research

authors： Ping P,Takano H,Zhang J,Tang XL,Qiu Y,Li RC,Banerjee S,Dawn B,Balafonova Z,Bolli R

更新日期：1999-03-19 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：:We examined whether albumin-derived advanced glycosylation end products (AGEs) downregulate the expression of endothelial nitric oxide synthase (NOS). Significant reductions in NOS activity and cGMP levels in bovine aortic endothelial cells were observed when exposed to different concentrations of albumin-derived AGEs...

journal_title：Circulation research

authors： Rojas A,Romay S,González D,Herrera B,Delgado R,Otero K

更新日期：2000-02-18 00:00:00

abstract：:Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced an adenovirus vector encoding a marker gene human placental alkaline phosphatase into normal and atherosclerotic human v...

journal_title：Circulation research

authors： Rekhter MD,Simari RD,Work CW,Nabel GJ,Nabel EG,Gordon D

更新日期：1998-06-29 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：:The mechanism(s) by which mutations in sarcomeric proteins cause hypertrophic cardiomyopathy (HCM) remains unknown. A leading hypothesis proposes that mutant sarcomeric proteins impair cardiac myocyte contractility, providing an impetus for compensatory hypertrophy. To test this hypothesis, we determined the impact of...

journal_title：Circulation research

authors： Marian AJ,Zhao G,Seta Y,Roberts R,Yu QT

更新日期：1997-07-01 00:00:00

abstract：:The effects of Bay K 8644 on the high-threshold calcium channel was investigated by means of the whole-cell patch-clamp technique in single guinea pig ventricular myocytes. The goal of the experiments was to characterize the inhibitory effects of Bay K 8644 on the calcium channel, and identify the factors that influen...

journal_title：Circulation research

authors： Hadley RW,Hume JR

更新日期：1988-01-01 00:00:00

abstract：:Leukocyte-derived microparticles (LMPs) may originate from neutrophils, monocytes/macrophages, and lymphocytes. They express markers from their parental cells and harbor membrane and cytoplasmic proteins as well as bioactive lipids implicated in a variety of mechanisms, maintaining or disrupting vascular homeostasis. ...

journal_title：Circulation research

authors： Angelillo-Scherrer A

更新日期：2012-01-20 00:00:00

abstract：RATIONALE:Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of action of H(2)O(2) involve...

journal_title：Circulation research

authors： Zhang DX,Borbouse L,Gebremedhin D,Mendoza SA,Zinkevich NS,Li R,Gutterman DD

更新日期：2012-02-03 00:00:00

abstract：:Optimistic people have reduced risk for cardiovascular disease and cardiovascular-related mortality compared with their less optimistic peers. One explanation for this is that optimistic people may be more likely to engage in healthy behavior like exercising frequently, eating fruits and vegetables, and avoiding cigar...

journal_title：Circulation research

authors： Boehm JK,Chen Y,Koga H,Mathur MB,Vie LL,Kubzansky LD

更新日期：2018-04-13 00:00:00

abstract：:Although functional coupling between protein kinase Cepsilon (PKCepsilon) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable this link and the identities of the mitochondrial proteins modulated by PKCepsilon remain unknown. Based on recent evidence t...

journal_title：Circulation research

authors： Baines CP,Song CX,Zheng YT,Wang GW,Zhang J,Wang OL,Guo Y,Bolli R,Cardwell EM,Ping P

更新日期：2003-05-02 00:00:00

abstract：RATIONALE:Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined. OBJECTIVE:Determine the ability of PAI-1 to regulate myoendothelial junction (MEJ) formation. METHODS AND RESULTS:MEJs are found throughout the vas...

journal_title：Circulation research

authors： Heberlein KR,Straub AC,Best AK,Greyson MA,Looft-Wilson RC,Sharma PR,Meher A,Leitinger N,Isakson BE

更新日期：2010-04-02 00:00:00

abstract：:The abundance of membrane cholesterol is an important determinant of the functional properties of biomembranes. To determine whether arterial smooth muscle acquires altered contractile properties in a high cholesterol environment, isolated canine coronary arteries were exposed to cholesterol in stable aqueous solution...

journal_title：Circulation research

authors： Yokoyama M,Henry PD

更新日期：1979-10-01 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Previous PAGE-immunoblotting studies indicated that several human tissues display an immunoreactive band with an electrophoretic mobility identica...

journal_title：Circulation research

authors： Masouyé I,Hagens G,Van Kuppevelt TH,Madsen P,Saurat JH,Veerkamp JH,Pepper MS,Siegenthaler G

更新日期：1997-09-01 00:00:00

abstract：:Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic...

journal_title：Circulation research

authors： Weinberger MH,Aoi W,Henry DP

更新日期：1975-09-01 00:00:00

abstract：:Herein, we show that the paired-related homeobox gene, Prx1, is required for lung vascularization. Initial studies revealed that Prx1 localizes to differentiating endothelial cells (ECs) within the fetal lung mesenchyme, and later within ECs forming vascular networks. To begin to determine whether Prx1 promotes EC dif...

journal_title：Circulation research

authors： Ihida-Stansbury K,McKean DM,Gebb SA,Martin JF,Stevens T,Nemenoff R,Akeson A,Vaughn J,Jones PL

更新日期：2004-06-11 00:00:00

abstract：:Mutations in the human gene encoding the nucleotide-binding region in the gamma-subunit of AMP-activated protein kinase (AMPK) cause cardiomyopathy with preexcitation syndrome. Mutant AMPK showed reduced binding affinity to nucleotides in vitro raising the possibility that altered regulation of AMPK activity by AMP/AT...

journal_title：Circulation research

authors： Zou L,Shen M,Arad M,He H,Løfgren B,Ingwall JS,Seidman CE,Seidman JG,Tian R

更新日期：2005-08-19 00:00:00

abstract：:We investigated the effects of streptozotocin-induced diabetes on atrial natriuretic peptide (ANP) synthesis, hemodynamic parameters, blood volume, and histopathology, as well as the reversibility of such effects with insulin therapy in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). The biatrial A...

journal_title：Circulation research

authors： Matsubara H,Mori Y,Yamamoto J,Inada M

更新日期：1990-10-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable technique...

journal_title：Circulation research

authors： van Rooij E

更新日期：2011-01-21 00:00:00

abstract：:We tested the hypothesis that TNF-alpha induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface ICAM-1, the beta2-integrin (CD11/CD18) counter-receptor. Stimulation of human pulmonary artery endothelial cells with TNF-alpha resulted in phosphorylation of ICAM-1 wit...

journal_title：Circulation research

authors： Javaid K,Rahman A,Anwar KN,Frey RS,Minshall RD,Malik AB

更新日期：2003-05-30 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:Voltage-gated L-type Ca(2+) channels (LCCs) provide Ca(2+) ingress into cardiac myocytes and play a key role in intracellular Ca(2+) homeostasis and excitation-contraction coupling. We investigated the effects of a constitutive increase of LCC density on Ca(2+) signaling in ventricular myocytes from 4-month-old transg...

journal_title：Circulation research

authors： Song LS,Guia A,Muth JN,Rubio M,Wang SQ,Xiao RP,Josephson IR,Lakatta EG,Schwartz A,Cheng H

更新日期：2002-02-08 00:00:00

abstract：RATIONALE:Activation of the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) has been implicated in the mechanism of cardiac ischemic preconditioning, yet its molecular composition is unknown. OBJECTIVE:To use an unbiased proteomic analysis of the mitochondrial inner membrane to identify the mitochondrial K(...

journal_title：Circulation research

authors： Foster DB,Ho AS,Rucker J,Garlid AO,Chen L,Sidor A,Garlid KD,O'Rourke B

更新日期：2012-08-03 00:00:00

abstract：:Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

journal_title：Circulation research

authors： Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

更新日期：2009-04-10 00:00:00