Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.

abstract：RATIONALE:Postconditioning at the time of primary percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction may reduce infarct size and improve myocardial salvage. However, clinical trials have shown inconsistent benefit. OBJECTIVE:We performed the first National Heart, Lung, and Blood In...

journal_title：Circulation research

authors： Traverse JH,Swingen CM,Henry TD,Fox J,Wang YL,Chavez IJ,Lips DL,Lesser JR,Pedersen WR,Burke NM,Pai A,Lindberg JL,Garberich RF

更新日期：2019-03-01 00:00:00

abstract：RATIONALE:Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca(2+)-dependent multi-effector phosphatase. Calcineurin inhibitors such as cyclosporine A (CsA) were shown to be effe...

journal_title：Circulation research

authors： Yu H,Bot I,Sliedregt K,Xu X,Bot M,van Heiningen SH,van der Marel GA,Bennett MR,Overkleeft H,van Berkel TJ,Biessen EA

更新日期：2012-01-20 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:In 36 normolipemic pigs randomized to a 4-week feeding with regular pig chow (n = 18, control group) or chow supplemented with cod liver oil (1 ml/kg per day) (n = 18, treated group), treatment with cod liver oil produced a significant decrease in serum cholesterol, low density lipoprotein cholesterol, and triglycerid...

journal_title：Circulation research

authors： Lam JY,Badimon JJ,Ellefson RD,Fuster V,Chesebro JH

更新日期：1992-10-01 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：:To gain some insight into inotropic mechanisms, we compared the effects of several classes of inotropic interventions on the isometric twitch and force-velocity properties of isolated rabbit myocardium. Postextrasystolic potentiation was chosen as one of the interventions in the belief that its onset is so rapid that ...

journal_title：Circulation research

authors： Chiu YC,Walley KR,Ford LE

更新日期：1989-11-01 00:00:00

abstract：:We studied the pulmonary vascular effects of prostacylin, PGI2, in the cat with intact chest under conditions of controlled blood flow. Intralobar injections of PGI2, 0.03--1 microgram, decreased arterial pressure in the perfused lobe in a dose-dependent manner. Inasmuch as lobar blood flow was held constant and left ...

journal_title：Circulation research

authors： Hyman AL,Kadowitz PJ

更新日期：1979-09-01 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：:A method was developed for recording isometric tension from isolated small arteries (mean internal diameter, 169 microns) and veins (mean internal diameter, 273 microns) of the term fetal lung and was then applied to the study of the mechanisms controlling perinatal pulmonary hemodynamics. The specific purpose was to ...

journal_title：Circulation research

authors： Wang Y,Coceani F

更新日期：1992-08-01 00:00:00

abstract：RATIONALE:Myocardial infarction causes irreversible tissue damage, leading to heart failure. We recently discovered that canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse hearts after infarction. Wnt10b regulates cell fate in various organs, but its role in the heart is unknown. OBJECTIVE:To ...

journal_title：Circulation research

authors： Paik DT,Rai M,Ryzhov S,Sanders LN,Aisagbonhi O,Funke MJ,Feoktistov I,Hatzopoulos AK

更新日期：2015-10-09 00:00:00

abstract：:Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 an...

journal_title：Circulation research

authors： Fischer A,Steidl C,Wagner TU,Lang E,Jakob PM,Friedl P,Knobeloch KP,Gessler M

更新日期：2007-03-30 00:00:00

abstract：:The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) trans...

journal_title：Circulation research

authors： Litwin SE,Zhang D,Bridge JH

更新日期：2000-11-24 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:First-generation, E1-deleted adenoviral vectors (E1-AV) can transduce the vascular endothelium with high efficiency, but their use is limited by the resulting acute endothelial injury and the long-term development of intimal hyperplasia. To reduce the impact of viral proteins on the gene-modified cells, a second-gener...

journal_title：Circulation research

authors： Qian HS,Channon K,Neplioueva V,Wang Q,Finer M,Tsui L,George SE,McArthur J

更新日期：2001-05-11 00:00:00

abstract：:Although the molecular effectors of apoptotic cell death have been largely annotated over the past 30 years, leading to a strong biological understanding of this process and its importance in cell biology, cell death through necrosis has only recently been accepted as a similarly regulated process with definable molec...

journal_title：Circulation research

authors： Karch J,Molkentin JD

更新日期：2015-05-22 00:00:00

abstract：:The structure-function relationships of the sarcomeric proteins in the mammalian cardiac compartment remain ill-defined because of the lack of a suitable model in which they can be readily manipulated or exchanged in vivo. To establish the validity of the transgenic paradigm for remodeling the mammalian heart, the mur...

journal_title：Circulation research

authors： Palermo J,Gulick J,Colbert M,Fewell J,Robbins J

更新日期：1996-03-01 00:00:00

abstract：:Muscle ring finger (MuRF) proteins have been implicated in transmitting mechanical forces to cell signaling pathways through their interactions with the giant protein titin. Recent evidence has linked mechanically-induced stimuli with the control of serum response factor activity and localization through MuRF2. This o...

journal_title：Circulation research

authors： Willis MS,Ike C,Li L,Wang DZ,Glass DJ,Patterson C

更新日期：2007-03-02 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:High affinity binding sites of angiotensin II (A II) have been characterized in rabbit renomedullary interstitial cells in tissue culture. Binding was rapid, specific, and saturable. Scatchard analysis of steady state saturation binding data at 22 degrees C indicated a single binding site with an equilibrium dissociat...

journal_title：Circulation research

authors： Brown CA,Zusman RM,Haber E

更新日期：1980-06-01 00:00:00

abstract：:Fractalkine, a chemokine expressed by inflamed endothelium, induces leukocyte adhesion and migration via the receptor CX3CR1, and the CX3CR1 polymorphism V249I affects receptor expression and function. Here we show that this polymorphism is an independent risk factor for atherosclerotic coronary artery disease (CAD). ...

journal_title：Circulation research

authors： McDermott DH,Halcox JP,Schenke WH,Waclawiw MA,Merrell MN,Epstein N,Quyyumi AA,Murphy PM

更新日期：2001-08-31 00:00:00

abstract：:Nitroglycerin dilates large (greater than or equal to 100 microns) but not small coronary arterial microvessels, and a putative metabolite of nitroglycerin, S-nitroso-L-cysteine, has been shown in vitro to dilate both large and small coronary microvessels. Based on this evidence, we tested the hypothesis that the lack...

journal_title：Circulation research

authors： Kurz MA,Lamping KG,Bates JN,Eastham CL,Marcus ML,Harrison DG

更新日期：1991-03-01 00:00:00

abstract：:Electrocardiogram (ECG) electrodes and carotid arterial and superior vena caval (SVC) catheters were placed in eight nonpregnant ewes and 11 fetuses (109-129 days gestation) to measure heart rate, arterial presssure, P-R interval, left ventricular pre-ejection period (PEP), and left ventricular ejection time (LVET), b...

journal_title：Circulation research

authors： Berman W Jr,Ravenscroft PJ,Sheiner LB,Heymann MA,Melmon KL,Rudolph AM

更新日期：1977-11-01 00:00:00

abstract：:The purpose of this study was to investigate if myogenic responses of isolated coronary arterioles were dependent on an intact, functional endothelium. Arterioles were located in situ by intracoronary perfusion with india ink-gelatin solution and then dissected and cannulated at both ends with glass micropipettes. Int...

journal_title：Circulation research

authors： Kuo L,Chilian WM,Davis MJ

更新日期：1990-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...

journal_title：Circulation research

authors： Kim CH,Cho YS,Chun YS,Park JW,Kim MS

更新日期：2002-02-08 00:00:00

abstract：:The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...

journal_title：Circulation research

authors： Ruffy R,Lovelace DE,Mueller TM,Knoebel SB,Zipes DP

更新日期：1979-12-01 00:00:00

abstract：RATIONALE:In the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation myocardial infarction and left ventricular (LV) dysfunction after successf...

journal_title：Circulation research

authors： Achilli F,Pontone G,Bassetti B,Squadroni L,Campodonico J,Corrada E,Facchini C,Mircoli L,Esposito G,Scarpa D,Pidello S,Righetti S,Di Gennaro F,Guglielmo M,Muscogiuri G,Baggiano A,Limido A,Lenatti L,Di Tano G,Malafron

更新日期：2019-07-19 00:00:00

abstract：RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and ga...

journal_title：Circulation research

authors： Ren X,Ustiyan V,Pradhan A,Cai Y,Havrilak JA,Bolte CS,Shannon JM,Kalin TV,Kalinichenko VV

更新日期：2014-09-26 00:00:00

abstract：:alpha-Adrenergic receptor stimulation regulates the activity of a number of different cardiac ion channels, including those underlying one or more distinct Cl- conductances. The whole-cell patch-clamp technique was used in the present study to investigate the effects of alpha-adrenergic stimulation on the beta-adrener...

journal_title：Circulation research

authors： Oleksa LM,Hool LC,Harvey RD

更新日期：1996-06-01 00:00:00

abstract：:Hypertrophied cardiac myocytes exhibit prolonged action potentials and decreased transient outward potassium current (I(to)). Because Kv4.3 is a major contributor to I:(to), we studied regulation of its expression in neonatal rat cardiac myocytes in response to the known stimulators of cardiac myocyte hypertrophy, ang...

journal_title：Circulation research

authors： Zhang TT,Takimoto K,Stewart AF,Zhu C,Levitan ES

更新日期：2001-03-16 00:00:00

abstract：RATIONALE:Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is crucial for its function. Environmental cues mediate the remodeling process,...

journal_title：Circulation research

authors： Morooka N,Futaki S,Sato-Nishiuchi R,Nishino M,Totani Y,Shimono C,Nakano I,Nakajima H,Mochizuki N,Sekiguchi K

更新日期：2017-04-14 00:00:00