Independent regulation of cardiac Kv4.3 potassium channel expression by angiotensin II and phenylephrine.

abstract：:To study the effects of stretch on the function of rat left atrium, we recorded contraction force, calcium transients, and intracellular action potentials (APs) during stretch manipulations. The stretch of the atrium was controlled by intra-atrial pressure. The Frank-Starling behavior of the atrium was manifested as a...

journal_title：Circulation research

authors： Tavi P,Han C,Weckström M

更新日期：1998-11-30 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:It has been proposed that lipopolysaccharide (LPS) bound to the 60-kD LPS binding protein (LBP) forms an LPS/LBP complex that, in turn, binds to the CD14 receptor on monocytes/macrophages and stimulates the release of cytokines. We examined the role of LBP and CD14 in tumor necrosis factor-alpha (TNF-alpha) production...

journal_title：Circulation research

authors： Ishii Y,Wang Y,Haziot A,del Vecchio PJ,Goyert SM,Malik AB

更新日期：1993-07-01 00:00:00

abstract：RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...

journal_title：Circulation research

authors： Glessner JT,Bick AG,Ito K,Homsy J,Rodriguez-Murillo L,Fromer M,Mazaika E,Vardarajan B,Italia M,Leipzig J,DePalma SR,Golhar R,Sanders SJ,Yamrom B,Ronemus M,Iossifov I,Willsey AJ,State MW,Kaltman JR,White PS,Shen Y

更新日期：2014-10-24 00:00:00

abstract：:Coronary pressure-flow relations during autoregulated and vasodilated flow states were compared between eight dogs with renovascular hypertension and left ventricular hypertrophy and 12 normal dogs. Each relation was constructed from serial steady-state measurements of end-diastolic coronary pressure and flow during p...

journal_title：Circulation research

authors： Jeremy RW,Fletcher PJ,Thompson J

更新日期：1989-07-01 00:00:00

abstract：:The structure-function relationships of the sarcomeric proteins in the mammalian cardiac compartment remain ill-defined because of the lack of a suitable model in which they can be readily manipulated or exchanged in vivo. To establish the validity of the transgenic paradigm for remodeling the mammalian heart, the mur...

journal_title：Circulation research

authors： Palermo J,Gulick J,Colbert M,Fewell J,Robbins J

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholester...

journal_title：Circulation research

authors： Nelson JK,Sorrentino V,Avagliano Trezza R,Heride C,Urbe S,Distel B,Zelcer N

更新日期：2016-02-05 00:00:00

abstract：:The SCN5A gene encodes the alpha subunit of the human heart sodium channel (hH1), which plays a critical role in cardiac excitability. Mutations of SCN5A underlie Brugada syndrome, an inherited disorder that leads to ventricular fibrillation and sudden death. This study describes changes in cellular localization and f...

journal_title：Circulation research

authors： Baroudi G,Pouliot V,Denjoy I,Guicheney P,Shrier A,Chahine M

更新日期：2001-06-22 00:00:00

abstract：:The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been define...

journal_title：Circulation research

authors： Mommersteeg MT,Hoogaars WM,Prall OW,de Gier-de Vries C,Wiese C,Clout DE,Papaioannou VE,Brown NA,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-02-16 00:00:00

abstract：:A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle. The contractile element has been modeled taking into account the results of extensive mechanical tests that involved the recording of length-force and force-vel...

journal_title：Circulation research

authors： Izakov VYa,Katsnelson LB,Blyakhman FA,Markhasin VS,Shklyar TF

更新日期：1991-11-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascular smooth muscle cells (VSMCs). By zymography, OPN and tumor necrosi...

journal_title：Circulation research

authors： Lai CF,Seshadri V,Huang K,Shao JS,Cai J,Vattikuti R,Schumacher A,Loewy AP,Denhardt DT,Rittling SR,Towler DA

更新日期：2006-06-23 00:00:00

abstract：:Complete knowledge of myocardial structure, metabolism, and function is crucial to understanding the response of the heart to injury such as ischemia. Increasingly, this type of knowledge is required at multiple levels, from that of the isolated myocyte to the functioning organism, to provide basic scientists and clin...

journal_title：Circulation research

authors： Wu KC,Lima JA

更新日期：2003-12-12 00:00:00

abstract：:Vascular disease often involves vessel hypertrophy with underlying cellular hypertrophy or hyperplasia. Experimental diabetes stimulates hypertrophy of the rat mesenteric vasculature, and we investigated the hypothesis that this hypertrophy is associated with activation of Na(+)-H(+) exchange (NHE) activity. We measur...

journal_title：Circulation research

authors： Jandeleit-Dahm K,Hannan KM,Farrelly CA,Allen TJ,Rumble JR,Gilbert RE,Cooper ME,Little PJ

更新日期：2000-12-08 00:00:00

abstract：:During myocardial ischemia, electrical uncoupling and contracture herald irreversible damage. In the present study, we tested the hypothesis that an increase of intracellular Ca2+ is an important factor initiating these events. Therefore, we simultaneously determined tissue resistance, mechanical activity, pH(0), and ...

journal_title：Circulation research

authors： Dekker LR,Fiolet JW,VanBavel E,Coronel R,Opthof T,Spaan JA,Janse MJ

更新日期：1996-08-01 00:00:00

abstract：RATIONALE:Kawasaki disease (KD), an acute febrile vasculitis, is the most common cause of acquired heart disease in childhood; however, diagnosing KD can be difficult. OBJECTIVE:To identify unique proteomic biomarkers that can be used to facilitate earlier diagnosis of KD. METHODS AND RESULTS:We enrolled 214 children...

journal_title：Circulation research

authors： Ko TM,Kuo HC,Chang JS,Chen SP,Liu YM,Chen HW,Tsai FJ,Lee YC,Chen CH,Wu JY,Chen YT

更新日期：2015-02-27 00:00:00

abstract：:Mechanical forces participate in morphogenesis from the level of individual cells to whole organism patterning. This article reviews recent research that has identified specific roles for mechanical forces in important developmental events. One well defined example is that dynein-driven cilia create fluid flow that de...

journal_title：Circulation research

authors： Patwari P,Lee RT

更新日期：2008-08-01 00:00:00

abstract：:The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlu...

journal_title：Circulation research

authors： Richeson JF,Akiyama T,Schenk E

更新日期：1978-12-01 00:00:00

abstract：RATIONALE:A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial processes for muscle development and regeneration. OBJEC...

journal_title：Circulation research

authors： Renault MA,Vandierdonck S,Chapouly C,Yu Y,Qin G,Metras A,Couffinhal T,Losordo DW,Yao Q,Reynaud A,Jaspard-Vinassa B,Belloc I,Desgranges C,Gadeau AP

更新日期：2013-10-25 00:00:00

abstract：:Although human atherosclerosis is associated with aging, direct evidence of cellular senescence and the mechanism of senescence in vascular smooth muscle cells (VSMCs) in atherosclerotic plaques is lacking. We examined normal vessels and plaques by histochemistry, Southern blotting, and fluorescence in situ hybridizat...

journal_title：Circulation research

authors： Matthews C,Gorenne I,Scott S,Figg N,Kirkpatrick P,Ritchie A,Goddard M,Bennett M

更新日期：2006-07-21 00:00:00

abstract：:In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

journal_title：Circulation research

authors： Tohse N,Mészáros J,Sperelakis N

更新日期：1992-08-01 00:00:00

abstract：RATIONALE:Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. OBJECTIVE:To investigate the mechanism by which FGF signaling regulates cardiac progenitor cell differentiation. ME...

journal_title：Circulation research

authors： Zhang J,Liu J,Huang Y,Chang JY,Liu L,McKeehan WL,Martin JF,Wang F

更新日期：2012-02-17 00:00:00

abstract：RATIONALE:Giant-cell arteritis (GCA) is a large-vessel vasculitis characterized by immune cell infiltration, yet the potential involvement of neutrophils has rarely been studied. OBJECTIVE:We investigated whether alterations in neutrophil reactivity occurred in the pathogenesis of GCA or during its clinical management...

journal_title：Circulation research

authors： Nadkarni S,Dalli J,Hollywood J,Mason JC,Dasgupta B,Perretti M

更新日期：2014-01-17 00:00:00

abstract：:Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermor...

journal_title：Circulation research

authors： Rekhter MD,Hicks GW,Brammer DW,Work CW,Kim JS,Gordon D,Keiser JA,Ryan MJ

更新日期：1998-10-05 00:00:00

abstract：:Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during ath...

journal_title：Circulation research

authors： Franco C,Hou G,Ahmad PJ,Fu EY,Koh L,Vogel WF,Bendeck MP

更新日期：2008-05-23 00:00:00

abstract：:Existing evidence led us to hypothesize that increases in p85alpha, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85alpha, p110alpha, and p110delta mRNA was 1.5- to 2-fold higher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) co...

journal_title：Circulation research

authors： Veerasingham SJ,Yamazato M,Berecek KH,Wyss JM,Raizada MK

更新日期：2005-02-18 00:00:00

abstract：:Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

journal_title：Circulation research

authors： Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

更新日期：2009-04-10 00:00:00

abstract：RATIONALE:Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear. OBJECTIVE:We investigated the role of MAFbx in regulating cardiac hypertrophy and fu...

journal_title：Circulation research

authors： Usui S,Maejima Y,Pain J,Hong C,Cho J,Park JY,Zablocki D,Tian B,Glass DJ,Sadoshima J

更新日期：2011-07-08 00:00:00

abstract：:Apoptosis of smooth muscle cells (SMC) and degradation of the extracellular matrix (ECM) have both been implicated in atherosclerotic plaque rupture. We have previously reported that degraded type I collagen fragments induce a rapid but transient apoptotic burst initiated by calpains in SMC. The aim of the current stu...

journal_title：Circulation research

authors： von Wnuck Lipinski K,Keul P,Ferri N,Lucke S,Heusch G,Fischer JW,Levkau B

更新日期：2006-06-23 00:00:00

abstract：:We performed morphological studies of myocardial contracture to define its nature and relationship to mechanical changes occurring during metabolic blockade. Isolated rat papillary and trabecular muscles were stretched to the apices of their length-tension curves and stimulated to contract isometrically 12 times a min...

journal_title：Circulation research

authors： Bing OH,Fishbein MC

更新日期：1979-08-01 00:00:00

abstract：:The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO. In the present study, we investigated the contribution of...

journal_title：Circulation research

authors： Motterlini R,Gonzales A,Foresti R,Clark JE,Green CJ,Winslow RM

更新日期：1998-09-07 00:00:00