Paired-related homeobox gene Prx1 is required for pulmonary vascular development.

abstract：:Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascular smooth muscle cells (VSMCs). By zymography, OPN and tumor necrosi...

journal_title：Circulation research

authors： Lai CF,Seshadri V,Huang K,Shao JS,Cai J,Vattikuti R,Schumacher A,Loewy AP,Denhardt DT,Rittling SR,Towler DA

更新日期：2006-06-23 00:00:00

abstract：RATIONALE:Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negat...

journal_title：Circulation research

authors： Distel E,Barrett TJ,Chung K,Girgis NM,Parathath S,Essau CC,Murphy AJ,Moore KJ,Fisher EA

更新日期：2014-10-10 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:Recent studies have suggested a proangiogenic effect of angiotensin-converting enzyme (ACE) inhibition. We hypothesized that such a proangiogenic effect of ACE inhibition may be mediated, in part, by bradykinin (BK) B(2)-receptor pathway. This study therefore examined the neovascularization induced by ACE inhibitor tr...

journal_title：Circulation research

authors： Silvestre JS,Bergaya S,Tamarat R,Duriez M,Boulanger CM,Levy BI

更新日期：2001-10-12 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：:The positive inotropic response to angiotensin I and II in cardiac tissue of most mammalian species, as well as the exact site in the heart for conversion of local and systemic angiotensin I into angiotensin II, remains to be elucidated. In isolated cat papillary muscles, angiotensin I and angiotensin II (0.1 nM to 1 ...

journal_title：Circulation research

authors： Meulemans AL,Andries LJ,Brutsaert DL

更新日期：1990-06-01 00:00:00

abstract：:We examined the mechanism(s) of hypotensive action of platelet-activating factor (PAF) in anesthetized dogs. PAF (0.5 micrograms/kg i.v.) caused a biphasic hypotension; the first phase was transient and was accompanied by a decrease in systemic vascular resistance and an increase in cardiac output. Aspirin-DL-lysine, ...

journal_title：Circulation research

authors： Yamanaka S,Miura K,Yukimura T,Okumura M,Yamamoto K

更新日期：1992-05-01 00:00:00

abstract：:The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and high incidence of sudden death, despite causing little or no cardiac hypertrophy in patients. Transgenic mice expressing mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy...

journal_title：Circulation research

authors： Knollmann BC,Kirchhof P,Sirenko SG,Degen H,Greene AE,Schober T,Mackow JC,Fabritz L,Potter JD,Morad M

更新日期：2003-03-07 00:00:00

abstract：:We studied baroreceptor function in dogs before and after surgical repair of coarctation of the aorta by direct recording of multifiber carotid sinus (CS) nerve activity (NA) during alteration of pulsatile arterial pressure with systemic phenylephrine and nitroprusside, and during static pressure changes using a CS po...

journal_title：Circulation research

authors： Igler FO,Boerboom LE,Werner PH,Donegan JH,Zuperku EJ,Bonchek LI,Kampine JP

更新日期：1981-03-01 00:00:00

abstract：:alpha-Adrenergic stimulation (alpha-AS) and beta-adrenergic stimulation (beta-AS) of the myocardium are associated respectively with an increase and a decrease in myofilament responsiveness to Ca2+. We hypothesized that changes in cytosolic pH (pH(i)) may modulate these opposite actions of alpha-AS and beta-AS. The ef...

journal_title：Circulation research

authors： Gambassi G,Spurgeon HA,Lakatta EG,Blank PS,Capogrossi MC

更新日期：1992-10-01 00:00:00

abstract：:This study was designed to determine if opioids were detectable in cerebrospinal fluid (CSF) and if these concentrations were altered by hemorrhagic hypotension. This study was further designed to determine the effects of topically administered opioids on pial arteriolar diameter during normotension and hypotension. C...

journal_title：Circulation research

authors： Armstead WM,Mirro R,Busija DW,Desiderio DM,Leffler CW

更新日期：1991-04-01 00:00:00

abstract：:After myocardial infarction (MI), the noninfarcted myocardium undergoes significant hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes associated with the hypertrophied remodeled myocardium may play a key role in arrhythmia generation in the post-MI heart. We investigated the cellul...

journal_title：Circulation research

authors： Qin D,Zhang ZH,Caref EB,Boutjdir M,Jain P,el-Sherif N

更新日期：1996-09-01 00:00:00

abstract：:We studied the pulmonary vascular effects of prostacylin, PGI2, in the cat with intact chest under conditions of controlled blood flow. Intralobar injections of PGI2, 0.03--1 microgram, decreased arterial pressure in the perfused lobe in a dose-dependent manner. Inasmuch as lobar blood flow was held constant and left ...

journal_title：Circulation research

authors： Hyman AL,Kadowitz PJ

更新日期：1979-09-01 00:00:00

abstract：:Endothelial cells, either in vivo or freshly isolated, respond when exposed to muscarinic agonists with an increase in cytosolic free calcium concentration ([Ca2+]i) and release of endothelium-derived relaxing factor (EDRF). When placed in culture, however, endothelial cells rapidly lose these responses, which may be ...

journal_title：Circulation research

authors： Tracey WR,Peach MJ

更新日期：1992-02-01 00:00:00

abstract：:Calcium channel blockers are among the most commonly used therapeutic drugs. Nevertheless, the utility of calcium channel blockers for heart disease is limited because of the potent vasodilatory effect that causes hypotension, and other side effects attributable to blockade of noncardiac channels. Therefore, focal cal...

journal_title：Circulation research

authors： Murata M,Cingolani E,McDonald AD,Donahue JK,Marbán E

更新日期：2004-08-20 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular...

journal_title：Circulation research

authors： Holmer SR,Stevens S,Homcy CJ

更新日期：1989-10-01 00:00:00

abstract：:Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had seve...

journal_title：Circulation research

authors： Overend CL,Eisner DA,O'Neill SC

更新日期：2001-02-02 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic...

journal_title：Circulation research

authors： Weinberger MH,Aoi W,Henry DP

更新日期：1975-09-01 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00

abstract：:We compared the effects of the newer inotropic drugs, pimobendan (UD-CG 115 BS) and milrinone (Win 47203), on the electrical, mechanical and biochemical activity of intact and detergent-skinned preparations of cardiac muscle. Both of these agents increased contractile force of guinea pig papillary muscle preparations ...

journal_title：Circulation research

authors： Fujino K,Sperelakis N,Solaro RJ

更新日期：1988-11-01 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：:Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in dramatic changes in the release of adipokines, such as leptin and adiponectin, both of which have emerged as important regulators of car...

journal_title：Circulation research

authors： Lopaschuk GD,Folmes CD,Stanley WC

更新日期：2007-08-17 00:00:00

abstract：:We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 microgra...

journal_title：Circulation research

authors： Raffestin B,Levame M,Eddahibi S,Viossat I,Braquet P,Chabrier PE,Cantin M,Adnot S

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:The mechanisms driving atherothrombotic risk in individuals with JAK2 V617F ( Jak2 VF) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly understood. OBJECTIVE:The goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic ...

journal_title：Circulation research

authors： Wang W,Liu W,Fidler T,Wang Y,Tang Y,Woods B,Welch C,Cai B,Silvestre-Roig C,Ai D,Yang YG,Hidalgo A,Soehnlein O,Tabas I,Levine RL,Tall AR,Wang N

更新日期：2018-11-09 00:00:00

abstract：:Shear stress-induced activation of endothelial ion channels, one of the earliest responses to flow, is implicated in mechano-signal transduction that results in the regulation of vascular tone. The effects of laminar flow on endothelial membrane potential were studied in vitro using both fluorescent potentiometric dye...

journal_title：Circulation research

authors： Barakat AI,Leaver EV,Pappone PA,Davies PF

更新日期：1999-10-29 00:00:00

abstract：:A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle. The contractile element has been modeled taking into account the results of extensive mechanical tests that involved the recording of length-force and force-vel...

journal_title：Circulation research

authors： Izakov VYa,Katsnelson LB,Blyakhman FA,Markhasin VS,Shklyar TF

更新日期：1991-11-01 00:00:00

abstract：:The purpose of this study was to determine whether biphasic restitution of action potential duration (APD) in ventricular muscle permits the development of complex dynamic behavior. Such behavior is expected because of the steep ascending slope of restitution and the presence of a maximum. Action potentials recorded f...

journal_title：Circulation research

authors： Watanabe M,Otani NF,Gilmour RF Jr

更新日期：1995-05-01 00:00:00