Abstract:
:Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular library displays several unique residues compared with those from other species. In contrast to previously described complementary DNA clones for Gi alpha 2, this complementary DNA has a complete 3'-untranslated region with the expected consensus sequence for polyadenylation. Gi alpha 2 is the predominant isoform in the heart, and its message level of 14.7 +/- 4.9 pg/10 micrograms total ventricular RNA is about fourfold lower than that of the stimulatory guanine nucleotide-binding protein.
journal_name
Circ Resjournal_title
Circulation researchauthors
Holmer SR,Stevens S,Homcy CJdoi
10.1161/01.res.65.4.1136subject
Has Abstractpub_date
1989-10-01 00:00:00pages
1136-40issue
4eissn
0009-7330issn
1524-4571journal_volume
65pub_type
杂志文章abstract::Some statistical techniques for analyzing the kinds of studies typically reported in Circulation Research are described. Particular emphasis is given to the comparison of means from more than two populations, the joint effect of several experimentally controlled variables, and the analysis of studies with repeated mea...
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更新日期:1989-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.49.2.442
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更新日期:2018-06-08 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.173153
更新日期:2008-05-09 00:00:00
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更新日期:1992-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-10-01 00:00:00
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更新日期:2013-07-05 00:00:00