Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.

abstract：:Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized alpha4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endoth...

journal_title：Circulation research

authors： Goldfinger LE,Tzima E,Stockton R,Kiosses WB,Kinbara K,Tkachenko E,Gutierrez E,Groisman A,Nguyen P,Chien S,Ginsberg MH

更新日期：2008-07-18 00:00:00

abstract：:Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

journal_title：Circulation research

authors： van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

更新日期：2020-06-19 00:00:00

abstract：:By use of gene targeting and/or transgenesis, it is now possible to make defined changes in genes whose functions underlie mammalian cardiovascular function. Because of technical and economic considerations, these experiments are largely confined to the mouse. Genetic modification of the loci responsible for aspects o...

journal_title：Circulation research

authors： James JF,Hewett TE,Robbins J

更新日期：1998-03-09 00:00:00

abstract：RATIONALE:PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. OBJECTIVE:Here...

journal_title：Circulation research

authors： Rykaczewska U,Suur BE,Röhl S,Razuvaev A,Lengquist M,Sabater-Lleal M,van der Laan SW,Miller CL,Wirka RC,Kronqvist M,Gonzalez Diez M,Vesterlund M,Gillgren P,Odeberg J,Lindeman JH,Veglia F,Humphries SE,de Faire U,Baldass

更新日期：2020-02-28 00:00:00

abstract：:A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

journal_title：Circulation research

authors： Tada M,Kirchberger MA,Iorio JM,Katz AM

更新日期：1975-01-01 00:00:00

abstract：:We investigated the effects of streptozotocin-induced diabetes on atrial natriuretic peptide (ANP) synthesis, hemodynamic parameters, blood volume, and histopathology, as well as the reversibility of such effects with insulin therapy in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). The biatrial A...

journal_title：Circulation research

authors： Matsubara H,Mori Y,Yamamoto J,Inada M

更新日期：1990-10-01 00:00:00

abstract：:The purpose of this study was to examine by freeze-fracture the ultrastructure of intercellular junctions between mouse pulmonary endothelial and epithelial cells, and to relate this fine structure to that deduced from previous physiological and ultrastructural studies using tracer techniques. Junctions between capill...

journal_title：Circulation research

authors： Schneeberger EE,Karnovsky MJ

更新日期：1976-05-01 00:00:00

abstract：:We examined the function of the interventricular septum in six open-chest dogs by inserting piezoelectric crystals into the interventricular septum. Continuous ultrasonic recordings showed that the changes in myocardial chord length (MCL) in the septum and free walls of the right and left ventricle were similar during...

journal_title：Circulation research

authors： Molaug M,Stokland O,Ilebekk A,Lekven J,Kiil F

更新日期：1981-07-01 00:00:00

abstract：:We studied mitochondrial structure and intermediates of fatty acid metabolism in mitochondria isolated from ischemic hearts. By electron microscopy, no structural difference was detected between mitochondria isolated from control hearts and from ischemic hearts receiving glucose as the only substrate. However, major d...

journal_title：Circulation research

authors： Feuvray D,Plouët J

更新日期：1981-05-01 00:00:00

abstract：:Peripheral blood (PB)-derived CD14+ monocytes were shown to transdifferentiate into endothelial cell (EC) lineage cells and contribute to neovascularization. We investigated whether bone marrow (BM)- or PB-derived CD34-/CD14+ cells are involved in reendothelialization after carotid balloon injury. Although neither hem...

journal_title：Circulation research

authors： Fujiyama S,Amano K,Uehira K,Yoshida M,Nishiwaki Y,Nozawa Y,Jin D,Takai S,Miyazaki M,Egashira K,Imada T,Iwasaka T,Matsubara H

更新日期：2003-11-14 00:00:00

abstract：:Reductions in fluid shear stress produce endothelium-dependent vasoconstriction and promote neointimal hyperplasia, but the intracellular signaling mechanisms involved in these processes are poorly understood. To examine whether decreases in fluid shear stress affect endothelial cytosolic pH, carboxy-seminaphthorhodaf...

journal_title：Circulation research

authors： Ziegelstein RC,Blank PS,Cheng L,Capogrossi MC

更新日期：1998-04-20 00:00:00

abstract：:Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial perme...

journal_title：Circulation research

authors： Weiss JN,Korge P,Honda HM,Ping P

更新日期：2003-08-22 00:00:00

abstract：:Oxygen free radicals have the ability to oxidize cholesterol. However, nothing is known about the effects of cholesterol oxidation on ion transport in isolated myocardial membranes. The purpose of the present study was to investigate the effects of in situ oxidative modification of sarcolemmal cholesterol on Ca2+ flux...

journal_title：Circulation research

authors： Kutryk MJ,Maddaford TG,Ramjiawan B,Pierce GN

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury has not been assessed. OBJECTIVE:We tested the hypothesis that removal of a...

journal_title：Circulation research

authors： Conklin DJ,Guo Y,Jagatheesan G,Kilfoil PJ,Haberzettl P,Hill BG,Baba SP,Guo L,Wetzelberger K,Obal D,Rokosh DG,Prough RA,Prabhu SD,Velayutham M,Zweier JL,Hoetker JD,Riggs DW,Srivastava S,Bolli R,Bhatnagar A

更新日期：2015-08-14 00:00:00

abstract：:Inherited restrictive cardiomyopathy (RCM) is a debilitating disease characterized by a stiff heart with impaired ventricular relaxation. Mutations in cardiac troponin I (cTnI) were identified as causal for RCM. Acute genetic engineering of adult cardiac myocytes was used to identify primary structure/function effects...

journal_title：Circulation research

authors： Davis J,Wen H,Edwards T,Metzger JM

更新日期：2007-05-25 00:00:00

abstract：RATIONALE:The cardiac inwardly rectifying K(+) current (I(K1)) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential. OBJECTIVE:This study aims to analyze the effects of nitric oxide (NO) on human atrial I(K1) and on Kir2.1 channe...

journal_title：Circulation research

authors： Gómez R,Caballero R,Barana A,Amorós I,Calvo E,López JA,Klein H,Vaquero M,Osuna L,Atienza F,Almendral J,Pinto A,Tamargo J,Delpón E

更新日期：2009-08-14 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMC) is a primary cause of vascular disorders and is associated with major alterations in Ca2+ handling supported by loss of the sarco/endoplasmic reticulum calcium ATPase, SERCA2a. To determine the importance of SERCA2a in neointima formation, we have prevented loss of ...

journal_title：Circulation research

authors： Lipskaia L,del Monte F,Capiod T,Yacoubi S,Hadri L,Hours M,Hajjar RJ,Lompré AM

更新日期：2005-09-02 00:00:00

abstract：:The effects of synthetic human atrial 28-amino acid peptide (alpha-human atrial polypeptide) on systemic and renal hemodynamics were examined in two separate groups of Inactin-anesthetized rats. First, mean arterial pressure, heart rate, and cardiac output were measured before and during infusion of the peptide at rat...

journal_title：Circulation research

authors： Hirata Y,Ishii M,Sugimoto T,Matsuoka H,Sugimoto T,Kangawa K,Matsuo H

更新日期：1985-10-01 00:00:00

abstract：:The activity of the adrenergic system plays an important role in the genesis of malignant arrhythmias and the spreading of the infarcted zone in acute myocardial ischemia. Acute myocardial ischemia induces an increased activity of adenylyl cyclase. This sensitization at the enzyme level as shown in the isolated perfus...

journal_title：Circulation research

authors： Strasser RH,Braun-Dullaeus R,Walendzik H,Marquetant R

更新日期：1992-06-01 00:00:00

abstract：RATIONALE:Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear. OBJECTIVE:We investigated the role of MAFbx in regulating cardiac hypertrophy and fu...

journal_title：Circulation research

authors： Usui S,Maejima Y,Pain J,Hong C,Cho J,Park JY,Zablocki D,Tian B,Glass DJ,Sadoshima J

更新日期：2011-07-08 00:00:00

abstract：:Cardiac hemodynamics, diameter, blood flow velocity, and volumic flow of the brachial artery were studied before and after diltiazem administration in 11 patients with sustained essential hypertension. The study was compared with the hemodynamic effects of dihydralazine. The caliber of the brachial artery was evaluate...

journal_title：Circulation research

authors： Safar ME,Simon AC,Levenson JA,Cazor JL

更新日期：1983-02-01 00:00:00

abstract：:In recent year, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and ...

journal_title：Circulation research

authors： Uchida S,Dimmeler S

更新日期：2015-02-13 00:00:00

abstract：RATIONALE:Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor. However, there is lack of experimental evidence. OBJECTIVE:In this study, we investigated inflammation-associated stroke using a mouse model that ...

journal_title：Circulation research

authors： Hollander MC,Latour LL,Yang D,Ishii H,Xiao Z,Min Y,Ray-Choudhury A,Munasinghe J,Merchant AS,Lin PC,Hallenbeck J,Boehm M,Yang L

更新日期：2017-12-08 00:00:00

abstract：:Excitation-contraction coupling in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca²(+) transport. The complexity and integrative nature of heart cell electrophysiology and Ca²(+) cycling has led to an evolution of computational models that have played a crucial role in s...

journal_title：Circulation research

authors： Greenstein JL,Winslow RL

更新日期：2011-01-07 00:00:00

abstract：:Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction. In this report, we link Notch signaling to platelet-derived growth factor (PDGF) signaling, a ...

journal_title：Circulation research

authors： Jin S,Hansson EM,Tikka S,Lanner F,Sahlgren C,Farnebo F,Baumann M,Kalimo H,Lendahl U

更新日期：2008-06-20 00:00:00

abstract：:Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and...

journal_title：Circulation research

authors： Wagner S,Maier LS,Bers DM

更新日期：2015-06-05 00:00:00

abstract：:The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Fi...

journal_title：Circulation research

authors： Mommersteeg MT,Brown NA,Prall OW,de Gier-de Vries C,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-10-26 00:00:00

abstract：:Inflammatory cell infiltration is a feature of postischemic neovascularization. However, mechanisms leading to leukocyte attraction to the site of neovascularization are still undefined. We hypothesized that the CXC chemokine receptor 3 (CXCR3) may contribute to leukocyte accumulation and subsequently to blood vessel ...

journal_title：Circulation research

authors： Waeckel L,Mallat Z,Potteaux S,Combadière C,Clergue M,Duriez M,Bao L,Gerard C,Rollins BJ,Tedgui A,Levy BI,Silvestre JS

更新日期：2005-03-18 00:00:00

abstract：:We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid [EVF]) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were di...

journal_title：Circulation research

authors： Laine GA,Allen SJ

更新日期：1991-06-01 00:00:00

abstract：:Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link is yet established between the vascular pathology of the metabolic syndrome with a particular inflammatory cytokine. We hypothesized that impairments in coronary endothelial function in the obese...

journal_title：Circulation research

authors： Picchi A,Gao X,Belmadani S,Potter BJ,Focardi M,Chilian WM,Zhang C

更新日期：2006-07-07 00:00:00