Role of the mitochondrial permeability transition in myocardial disease.

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：:The aim of this study was to determine the mechanism of action of norepinephrine (NE) on arterial baroreceptors (BRs), with the focus on regularly discharging, presumably myelinated fibers. With the use of an in vitro aortic arch/aortic nerve preparation from rats, BR single-fiber discharge was recorded simultaneously...

journal_title：Circulation research

authors： Munch PA,Thoren PN,Brown AM

更新日期：1987-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity of endothelial cells. Although the mitogenic activity of VEGF is endothelial cell specific, recent reports indicate VEGF is able to stimulate chemotaxis and tissue factor...

journal_title：Circulation research

authors： Wang H,Keiser JA

更新日期：1998-10-19 00:00:00

abstract：:Bradykinin relaxes arterioles on the brain's surface. This response is endothelium-dependent. The data presented here confirm the hypothesis that hydroxyl free radical mediates this response and may be the endothelium-dependent relaxing factor for bradykinin in this microvascular bed. The response to a locally applied...

journal_title：Circulation research

authors： Rosenblum WI

更新日期：1987-10-01 00:00:00

abstract：:Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggest...

journal_title：Circulation research

authors： Gkaliagkousi E,Ritter J,Ferro A

更新日期：2007-09-28 00:00:00

abstract：:Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable technique...

journal_title：Circulation research

authors： van Rooij E

更新日期：2011-01-21 00:00:00

abstract：:Cyclic nucleotides are known to modify voltage-gated (L-type) Ca2+ channel activity in vascular smooth muscle cells, but the exact mechanism(s) underlying these effects is not well defined. The purpose of the present study was to investigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and P...

journal_title：Circulation research

authors： Ruiz-Velasco V,Zhong J,Hume JR,Keef KD

更新日期：1998-03-23 00:00:00

abstract：:Heart disease is often the end result of inherited genetic defects, which may potentially be treatable using a gene-transfer approach. Recombinant adeno-associated virus (rAAV)-mediated gene delivery has emerged as a realistic method for the treatment of such disorders. Here, we demonstrate and compare the natural aff...

journal_title：Circulation research

authors： Pacak CA,Mah CS,Thattaliyath BD,Conlon TJ,Lewis MA,Cloutier DE,Zolotukhin I,Tarantal AF,Byrne BJ

更新日期：2006-08-18 00:00:00

abstract：:Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during s...

journal_title：Circulation research

authors： Fallavollita JA,Malm BJ,Canty JM Jr

更新日期：2003-01-10 00:00:00

abstract：:Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality b...

journal_title：Circulation research

authors： West J,Fagan K,Steudel W,Fouty B,Lane K,Harral J,Hoedt-Miller M,Tada Y,Ozimek J,Tuder R,Rodman DM

更新日期：2004-04-30 00:00:00

abstract：:We have previously studied the relation between long-chain fatty acid and pyruvate metabolism in reperfused myocardium and noted a rapid return of fatty acid oxidation to at least preischemic values accompanied by a marked decrease in pyruvate oxidation. The purpose of the present report is to further characterize car...

journal_title：Circulation research

authors： Renstrom B,Nellis SH,Liedtke AJ

更新日期：1989-10-01 00:00:00

abstract：:Multiple voltage-gated K+ channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kv1.5 K+ channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K+ current. Previously, we found that...

journal_title：Circulation research

authors： Takimoto K,Levitan ES

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epicardial lineage durin...

journal_title：Circulation research

authors： van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ

更新日期：2009-08-28 00:00:00

abstract：:We have previously demonstrated pressure-dependent membrane depolarization and action potential generation in cat cerebral arteries. It was the purpose of this study to examine and compare the membrane electrical responses to increasing transmural pressure in spontaneously hypertensive rats with those of their normote...

journal_title：Circulation research

authors： Harder DR,Smeda J,Lombard J

更新日期：1985-08-01 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:Atrial fibrillation (AF) may result from stationary reentry in the left atrium (LA), with fibrillatory conduction toward the right atrium (RA). We hypothesize that periodic input to the RA at an exceedingly high frequency results in disorganized wave propagation, compatible with fibrillatory conduction. Simultaneous e...

journal_title：Circulation research

authors： Berenfeld O,Zaitsev AV,Mironov SF,Pertsov AM,Jalife J

更新日期：2002-06-14 00:00:00

abstract：:Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...

journal_title：Circulation research

authors： Liu DW,Gintant GA,Antzelevitch C

更新日期：1993-03-01 00:00:00

abstract：:Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...

journal_title：Circulation research

authors： Barbuti A,Gravante B,Riolfo M,Milanesi R,Terragni B,DiFrancesco D

更新日期：2004-05-28 00:00:00

abstract：:To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and ...

journal_title：Circulation research

authors： Nagasawa K,Tomoike H,Hayashi Y,Yamada A,Yamamoto T,Nakamura M

更新日期：1989-08-01 00:00:00

abstract：:We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and NMMHC-B are both 7.5 kb in size but are shown to be the products of different genes, which are localized to chromosome 22q11.2 and chromosome 17q13, respectively. In ...

journal_title：Circulation research

authors： Simons M,Wang M,McBride OW,Kawamoto S,Yamakawa K,Gdula D,Adelstein RS,Weir L

更新日期：1991-08-01 00:00:00

abstract：:Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significan...

journal_title：Circulation research

authors： Rethinasamy P,Muthuchamy M,Hewett T,Boivin G,Wolska BM,Evans C,Solaro RJ,Wieczorek DF

更新日期：1998-01-09 00:00:00

abstract：:Adenosine, a vasodilator metabolite, is often produced in tissues where the demand for oxygen exceeds the supply. We have recently demonstrated in isolated cannulated arterioles that adenosine and its metabolite, inosine, can also cause vasoconstriction by stimulation of mast cells. Secondary release of histamine and ...

journal_title：Circulation research

authors： Shepherd RK,Linden J,Duling BR

更新日期：1996-04-01 00:00:00

abstract：:The programmed onset of myocardial dysfunction and its progression to congestive heart failure in the cardiomyopathic Syrian hamster is hallmarked by alterations in myocellular calcium regulation. To determine whether calcium channel blockade is effective in halting the progressive depression of myocardial contractile...

journal_title：Circulation research

authors： Capasso JM,Sonnenblick EH,Anversa P

更新日期：1990-12-01 00:00:00

abstract：:The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...

journal_title：Circulation research

authors： Ruffy R,Lovelace DE,Mueller TM,Knoebel SB,Zipes DP

更新日期：1979-12-01 00:00:00

abstract：:Given the essential role played by gap junctions in the coordination of cardiac muscle contraction, it is plausible that down-regulation of gap junctional conduction is in part responsible for the contractile dysfunction observed in hypertrophied and failing hearts. In the present study, we analyzed the expression and...

journal_title：Circulation research

authors： Toyofuku T,Yabuki M,Otsu K,Kuzuya T,Tada M,Hori M

更新日期：1999-10-15 00:00:00

abstract：:Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular...

journal_title：Circulation research

authors： Holmer SR,Stevens S,Homcy CJ

更新日期：1989-10-01 00:00:00

abstract：:In 57 normal subjects (age 20-60 years), we analyzed the spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90 degrees upright tilt, controlled respiration (n = 16) and acute (n = 10) and chronic (n = 12) beta-adrenergic receptor blockade. Automatic computer analysis provided the a...

journal_title：Circulation research

authors： Pagani M,Lombardi F,Guzzetti S,Rimoldi O,Furlan R,Pizzinelli P,Sandrone G,Malfatto G,Dell'Orto S,Piccaluga E

更新日期：1986-08-01 00:00:00

abstract：:Loss-of-function mutations in the human ERG1 potassium channel (hERG1) frequently underlie the long QT2 (LQT2) syndrome. The role of the ERG potassium channel in cardiac development was elaborated in an in vivo model of a homozygous, loss-of-function LQT2 syndrome mutation. The hERG N629D mutation was introduced into ...

journal_title：Circulation research

authors： Teng GQ,Zhao X,Lees-Miller JP,Quinn FR,Li P,Rancourt DE,London B,Cross JC,Duff HJ

更新日期：2008-12-05 00:00:00

abstract：:The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix. Dystrophin, the protein product of the Duc...

journal_title：Circulation research

authors： Lapidos KA,Kakkar R,McNally EM

更新日期：2004-04-30 00:00:00