Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles.

abstract：:The blood pressure of rabbits with chronic one-kidney hypertension can be lowered to normal by immunization with hog kidney cortex preparations that do not contain renin, thus providing evidence for a new factor essential for the maintenance of an elevated blood pressure. A search for the new factor has led to the dis...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1977-02-01 00:00:00

abstract：:Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to generate carbon monoxide (a vasodilatory gas that has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron (sequestered by ferritin). Because of properties of HO and its products, we hypothesi...

journal_title：Circulation research

authors： Wiesel P,Patel AP,Carvajal IM,Wang ZY,Pellacani A,Maemura K,DiFonzo N,Rennke HG,Layne MD,Yet SF,Lee ME,Perrella MA

更新日期：2001-05-25 00:00:00

abstract：:Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or genetic disturbances in homocysteine metabolism. A polymorphism in methylenetetrahydrofolate reductase (MTHFR) is the most common genetic cause of mild hyperhomocysteinemia. To examine mechanisms by which an elevation in plasma...

journal_title：Circulation research

authors： Mikael LG,Genest J Jr,Rozen R

更新日期：2006-03-03 00:00:00

abstract：:The effects of exercise training on the coronary vasodilation following activation of the Bezold-Jarisch reflex were examined in conscious dogs. Mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and left circumflex coronary blood flow (CBF). With the heart ra...

journal_title：Circulation research

authors： Zhao G,Zhang X,Xu X,Ochoa M,Hintze TH

更新日期：1997-06-01 00:00:00

abstract：:In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia followed by reoxygenation (hypoxia/reoxygenati...

journal_title：Circulation research

authors： Seko Y,Tobe K,Ueki K,Kadowaki T,Yazaki Y

更新日期：1996-01-01 00:00:00

abstract：:Nitric oxide (NO), generated by platelets through stimulation of nitric oxide synthase (NOS), limits platelet adhesion and aggregation after a prothrombotic stimulus. Platelet beta-adrenoceptors (betaARs) mediate inhibition of aggregation, but no direct link has been shown between these receptors and platelet adhesion...

journal_title：Circulation research

authors： Queen LR,Xu B,Horinouchi K,Fisher I,Ferro A

更新日期：2000-07-07 00:00:00

abstract：:Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whethe...

journal_title：Circulation research

authors： Verschuren L,Kooistra T,Bernhagen J,Voshol PJ,Ouwens DM,van Erk M,de Vries-van der Weij J,Leng L,van Bockel JH,van Dijk KW,Fingerle-Rowson G,Bucala R,Kleemann R

更新日期：2009-07-02 00:00:00

abstract：:Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes generated by lipid peroxidation, suggesting that it may serve as an antioxidant defense. To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwent 6 cycles ...

journal_title：Circulation research

authors： Shinmura K,Bolli R,Liu SQ,Tang XL,Kodani E,Xuan YT,Srivastava S,Bhatnagar A

更新日期：2002-08-09 00:00:00

abstract：:Apoptosis of smooth muscle cells (SMC) and degradation of the extracellular matrix (ECM) have both been implicated in atherosclerotic plaque rupture. We have previously reported that degraded type I collagen fragments induce a rapid but transient apoptotic burst initiated by calpains in SMC. The aim of the current stu...

journal_title：Circulation research

authors： von Wnuck Lipinski K,Keul P,Ferri N,Lucke S,Heusch G,Fischer JW,Levkau B

更新日期：2006-06-23 00:00:00

abstract：:The role of Ca(2+)-dependent potassium channels in mediating vascular responses to activation of adenylate cyclase in vivo is not known. The goal of this study was to examine the hypothesis that dilatation of cerebral arterioles in response to activation of adenylate cyclase is mediated by activation of Ca(2+)-depende...

journal_title：Circulation research

authors： Taguchi H,Heistad DD,Kitazono T,Faraci FM

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:The mammalian diaphanous-related formin (mDia1), governs microtubule and microfilament dynamics while functioning as an effector for Rho small GTP-binding proteins during key cellular processes such as adhesion, cytokinesis, cell polarity, and morphogenesis. The cytoplasmic domain of the receptor for advanced...

journal_title：Circulation research

authors： Touré F,Fritz G,Li Q,Rai V,Daffu G,Zou YS,Rosario R,Ramasamy R,Alberts AS,Yan SF,Schmidt AM

更新日期：2012-05-11 00:00:00

abstract：:In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in the formation of a collagen-based scar. Necrotic cells release danger signals, activating innate immune pathways and triggering an intense inflammatory response. Stimula...

journal_title：Circulation research

authors： Prabhu SD,Frangogiannis NG

更新日期：2016-06-24 00:00:00

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：:We tested the hypothesis that a parenchymally derived mediator is required for arterioles to exhibit oxygen sensitivity. To that end, the parenchyma was dissected and removed from around hamster cheek pouch arterioles, and the oxygen sensitivity of these "aparenchymal arteriolar segments" was studied, either in vitro,...

journal_title：Circulation research

authors： Jackson WF,Duling BR

更新日期：1983-10-01 00:00:00

abstract：:The mechanism of adenosine-induced inhibition of Ca2+ currents was studied by recording single-channel Ca2+ currents from cell-attached patches on isolated guinea pig ventricular cells with pipettes containing 50 or 100 mM Ba2+. Numerous 100-msec depolarization steps were applied repetitively at 2 Hz from the resting ...

journal_title：Circulation research

authors： Kato M,Yamaguchi H,Ochi R

更新日期：1990-11-01 00:00:00

abstract：:It is well known that electrical pacing may either terminate or change the rate and/or ECG appearance of reentrant ventricular tachycardia. However, the dynamics of interaction of reentrant waves with waves initiated by external pacing are poorly understood. Prevailing concepts are based on simplistic models in which ...

journal_title：Circulation research

authors： Davidenko JM,Salomonsz R,Pertsov AM,Baxter WT,Jalife J

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...

journal_title：Circulation research

authors： Kupfer ME,Lin WH,Ravikumar V,Qiu K,Wang L,Gao L,Bhuiyan DB,Lenz M,Ai J,Mahutga RR,Townsend D,Zhang J,McAlpine MC,Tolkacheva EG,Ogle BM

更新日期：2020-07-03 00:00:00

abstract：:The cardiovascular actions of the synthetic natriuretic peptide, atriopeptin II, were examined in conscious unrestrained spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. The animals were chronically instrumented with miniaturized pulsed Doppler flow probes to allow measurement of regional blood flow...

journal_title：Circulation research

authors： Lappe RW,Smits JF,Todt JA,Debets JJ,Wendt RL

更新日期：1985-04-01 00:00:00

abstract：:We performed morphological studies of myocardial contracture to define its nature and relationship to mechanical changes occurring during metabolic blockade. Isolated rat papillary and trabecular muscles were stretched to the apices of their length-tension curves and stimulated to contract isometrically 12 times a min...

journal_title：Circulation research

authors： Bing OH,Fishbein MC

更新日期：1979-08-01 00:00:00

abstract：RATIONALE:Aortic valve disease is a cell-mediated process without effective pharmacotherapy. CNP (C-type natriuretic peptide) inhibits myofibrogenesis and osteogenesis of cultured valve interstitial cells and is downregulated in stenotic aortic valves. However, it is unknown whether CNP signaling regulates aortic valve...

journal_title：Circulation research

authors： Blaser MC,Wei K,Adams RLE,Zhou YQ,Caruso LL,Mirzaei Z,Lam AY,Tam RKK,Zhang H,Heximer SP,Henkelman RM,Simmons CA

更新日期：2018-02-02 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：:The effects of digoxin on monovalent cation active transport were determined in cardiac tissue obtained from dogs given inotropic, toxic, or lethal doses of digoxin. In hemodynamically monitored dogs, active uptake of the K+ analogue Rb+ was determined in vitro in a control myocardial biopsy, and then in serial biopsi...

journal_title：Circulation research

authors： Hougen TJ,Lloyd BL,Smith TW

更新日期：1979-01-01 00:00:00

abstract：:Endothelins exert potent excitatory cardiac effects by acting on specific receptors on myocytes. In this study, we have examined the signal transduction mechanism for the chronotropic effect of endothelins in guinea pig atria. A competition binding of [125I]endothelin 1 ([125I]ET-1) using the recently developed ETA re...

journal_title：Circulation research

authors： Ono K,Eto K,Sakamoto A,Masaki T,Shibata K,Sada T,Hashimoto K,Tsujimoto G

更新日期：1995-02-01 00:00:00

abstract：:Alveolar epithelial beta-adrenergic receptor (betaAR) activation accelerates active Na+ transport in lung epithelial cells in vitro and speeds alveolar edema resolution in human lung tissue and normal and injured animal lungs. Whether these receptors are essential for alveolar fluid clearance (AFC) or if other mechani...

journal_title：Circulation research

authors： Mutlu GM,Dumasius V,Burhop J,McShane PJ,Meng FJ,Welch L,Dumasius A,Mohebahmadi N,Thakuria G,Hardiman K,Matalon S,Hollenberg S,Factor P

更新日期：2004-04-30 00:00:00

abstract：RATIONALE:Carriers of the most common prothrombotic mutations FVL (factor V Leiden) and FII (prothrombin) 20210G>A show a highly variable clinical phenotype. Using standardized in vivo coagulation activation followed by activity pattern analysis we have recently shown, that the FVL mutation accelerates thrombin and APC...

journal_title：Circulation research

authors： Rühl H,Berens C,Winterhagen FI,Reda S,Müller J,Oldenburg J,Pötzsch B

更新日期：2019-08-16 00:00:00

abstract：RATIONALE:Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE:Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS:C57Bl6, Ace2 knockout (...

journal_title：Circulation research

authors： Thomas MC,Pickering RJ,Tsorotes D,Koitka A,Sheehy K,Bernardi S,Toffoli B,Nguyen-Huu TP,Head GA,Fu Y,Chin-Dusting J,Cooper ME,Tikellis C

更新日期：2010-10-01 00:00:00

abstract：:F2-Isoprostanes are novel bioactive prostaglandin F2-like compounds produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. F2-Isoprostanes are initially formed in situ on phospholipids and subsequently released. Quantification of the F2-isoprostanes has been found to represent a valuable and...

journal_title：Circulation research

authors： Moore KP,Darley-Usmar V,Morrow J,Roberts LJ 2nd

更新日期：1995-08-01 00:00:00

abstract：:Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreover, autophagy is sti...

journal_title：Circulation research

authors： De Meyer GR,Grootaert MO,Michiels CF,Kurdi A,Schrijvers DM,Martinet W

更新日期：2015-01-30 00:00:00

abstract：:Mitochondria have long been known to play a critical role in maintaining the bioenergetic status of cells under physiological conditions. It was also recognized early in mitochondrial research that the reduction of oxygen to generate the free radical superoxide occurs at various sites in the respiratory chain and was ...

journal_title：Circulation research

authors： Gutierrez J,Ballinger SW,Darley-Usmar VM,Landar A

更新日期：2006-10-27 00:00:00

abstract：:A potent transcriptional enhancer was previously identified upstream of the mouse renin gene. Within the enhancer is a TGACCT direct-repeat motif, required for enhancer activity, that is the consensus sequence recognized by members of the thyroid hormone subfamily of steroid hormone receptors. We previously reported t...

journal_title：Circulation research

authors： Liu X,Huang X,Sigmund CD

更新日期：2003-05-16 00:00:00