Abstract:
:Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-ATPase are involved in this regulation. We have learned a lot about the pathophysiological relevance of disturbed ion channel function from monogenetic disorders. Changes in the gating of a single ion channel and the activity of an ion pump suffice to dramatically increase the propensity for arrhythmias even in structurally normal hearts. Nevertheless, patients with heart failure with acquired dysfunction in many ion channels and transporters exhibit profound dysregulation of Na and Ca handling and Ca/calmodulin-dependent protein kinase and are especially prone to arrhythmias. A deeper understanding of the underlying arrhythmic principles is mandatory if we are to improve their outcome. This review addresses basic tachyarrhythmic mechanisms, the underlying ionic mechanisms and the consequences for ion homeostasis, and the situation in complex diseases like heart failure.
journal_name
Circ Resjournal_title
Circulation researchauthors
Wagner S,Maier LS,Bers DMdoi
10.1161/CIRCRESAHA.116.304678subject
Has Abstractpub_date
2015-06-05 00:00:00pages
1956-70issue
12eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.116.304678journal_volume
116pub_type
杂志文章,评审abstract::Cardiac and arterial tissues of six male and six female adult baboons were examined for nuclear uptake of tritiated 5-alpha-dihydrotestosterone (3H-DHT) or tritiated estradiol-17 beta (3H-E2) by autoradiography. 3H-DHT uptake occurred in nuclei of most atrial and ventricular myocardial fibers, no cardiac interstitial ...
journal_title:Circulation research
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doi:10.1161/01.res.48.2.238
更新日期:1981-02-01 00:00:00
abstract::In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus node, using the microelectrode technique. After the electrophysiological experiments, the preparations were subjected to a correlative morphological investigation, using light or electron microscopy. Different criteria for ...
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pub_type: 杂志文章
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更新日期:2018-02-02 00:00:00
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更新日期:2001-04-27 00:00:00
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pub_type: 杂志文章
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更新日期:2006-05-12 00:00:00
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pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.71.3.657
更新日期:1992-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000061571.49375.E1
更新日期:2003-03-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.4.977
更新日期:1991-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2006-06-23 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Circulation research
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更新日期:2015-02-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1977-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1981-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2005-08-05 00:00:00
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pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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更新日期:1999-09-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2002-12-13 00:00:00
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pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
abstract::A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.6.1652
更新日期:1991-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.49.2.337
更新日期:1981-08-01 00:00:00