Abstract:
:The activity of the adrenergic system plays an important role in the genesis of malignant arrhythmias and the spreading of the infarcted zone in acute myocardial ischemia. Acute myocardial ischemia induces an increased activity of adenylyl cyclase. This sensitization at the enzyme level as shown in the isolated perfused rat heart occurs rapidly after the onset of ischemia (5-15 minutes) and is rapidly reversible on reperfusion. With prolonged ischemia, it is only transient and is followed by a gradual loss of the adenylyl cyclase activity. The increased activity of adenylyl cyclase is even retained after partial purification, suggesting a covalent modification of the enzyme. Blockade of alpha 1-adrenergic receptors does not prevent this sensitization, demonstrating that it occurs independently of alpha 1-adrenergic receptor activation. Only blockade of protein kinase C by various inhibitors, such as polymyxin B or staurosporine, is able to completely prevent this sensitization process. Moreover, in acute myocardial ischemia an activation of protein kinase C could be identified using its translocation from the cytosol to the particulate fraction as an indicator. Blockade of alpha 1-adrenergic receptors using prazosin fails to prevent the activation of protein kinase C and consequently the sensitization of the adenylyl cyclase system, indicating that the ischemia-induced translocation of protein kinase C occurs independently of alpha 1-adrenergic receptors. These data characterize for the first time an important interaction of two effector enzymes of two distinct signal transduction pathways, i.e., the adenylyl cyclase system and the protein kinase C system in acute myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Circ Resjournal_title
Circulation researchauthors
Strasser RH,Braun-Dullaeus R,Walendzik H,Marquetant Rdoi
10.1161/01.res.70.6.1304subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1304-12issue
6eissn
0009-7330issn
1524-4571journal_volume
70pub_type
杂志文章abstract:RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...
journal_title:Circulation research
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCRESAHA.115.304458
更新日期:2014-10-24 00:00:00
abstract::Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celia...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/hh0801.089542
更新日期:2001-04-27 00:00:00
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更新日期:2007-03-02 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-18 00:00:00
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doi:10.1161/01.res.66.4.986
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pub_type: 杂志文章
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更新日期:1979-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-12-08 00:00:00
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更新日期:2013-07-05 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.49.6.1300
更新日期:1981-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/hh2401.100598
更新日期:2001-12-07 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.107.160176
更新日期:2008-02-15 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2012-02-17 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000132279.99249.f4
更新日期:2004-06-25 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000159389.55544.20
更新日期:2005-03-18 00:00:00
abstract::Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or s...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.61.1.42
更新日期:1987-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.5.1259
更新日期:1991-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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更新日期:1977-02-01 00:00:00
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更新日期:2010-05-14 00:00:00
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更新日期:2015-07-31 00:00:00
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pub_type: 杂志文章
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更新日期:2005-08-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.82.6.713
更新日期:1998-04-06 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1998-03-23 00:00:00
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pub_type: 杂志文章
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更新日期:2002-05-17 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-07 00:00:00
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pub_type: 杂志文章
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更新日期:2009-05-22 00:00:00
abstract::The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared wit...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.74.4.747
更新日期:1994-04-01 00:00:00