Expression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarction in transgenic mice.

abstract：RATIONALE:Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE:We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS:We identified CD40 as a...

journal_title：Circulation research

authors： Yang J,Fang P,Yu D,Zhang L,Zhang D,Jiang X,Yang WY,Bottiglieri T,Kunapuli SP,Yu J,Choi ET,Ji Y,Yang X,Wang H

更新日期：2016-11-11 00:00:00

abstract：RATIONALE:Despite significant interest in bone marrow mononuclear cell (BMC) therapy for ischemic heart disease, current techniques have resulted in only modest benefits. However, selected patients have shown improvements after autologous BMC therapy, but the contributing factors are unclear. OBJECTIVE:The purpose of ...

journal_title：Circulation research

authors： Schutt RC,Trachtenberg BH,Cooke JP,Traverse JH,Henry TD,Pepine CJ,Willerson JT,Perin EC,Ellis SG,Zhao DX,Bhatnagar A,Johnstone BH,Lai D,Resende M,Ebert RF,Wu JC,Sayre SL,Orozco A,Zierold C,Simari RD,Moyé L,Cogle

更新日期：2015-01-02 00:00:00

abstract：:Apoptosis of smooth muscle cells (SMC) and degradation of the extracellular matrix (ECM) have both been implicated in atherosclerotic plaque rupture. We have previously reported that degraded type I collagen fragments induce a rapid but transient apoptotic burst initiated by calpains in SMC. The aim of the current stu...

journal_title：Circulation research

authors： von Wnuck Lipinski K,Keul P,Ferri N,Lucke S,Heusch G,Fischer JW,Levkau B

更新日期：2006-06-23 00:00:00

abstract：RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...

journal_title：Circulation research

authors： Stiermaier T,Jensen JO,Rommel KP,de Waha-Thiele S,Fuernau G,Desch S,Thiele H,Eitel I

更新日期：2019-05-10 00:00:00

abstract：:The role of contracture in the manifestation of calcium paradox-induced damage was examined using 2,3-butanedione monoxime (BDM) to inhibit myofibrillar activity. Calcium and sodium gain, loss of intracellular components, and changes in structure were monitored. If 30 mM BDM was added at the time of calcium repletion ...

journal_title：Circulation research

authors： Daly MJ,Elz JS,Nayler WG

更新日期：1987-10-01 00:00:00

abstract：RATIONALE:Oxidative stress is an important contributing factor in several human pathologies ranging from atherosclerosis to cancer progression; however, the mechanisms underlying tissue protection from oxidation products are poorly understood. Oxidation of membrane phospholipids, containing the polyunsaturated fatty ac...

journal_title：Circulation research

authors： Kim YW,Yakubenko VP,West XZ,Gugiu GB,Renganathan K,Biswas S,Gao D,Crabb JW,Salomon RG,Podrez EA,Byzova TV

更新日期：2015-07-31 00:00:00

abstract：:T-wave alternans (TWA), an ABAB oscillation, has been postulated as the initial pattern in a stepwise progression to higher-order oscillations, culminating in sudden arrhythmic death. The present study is the first to provide experimental evidence to support this intriguing concept. Epicardial and endocardial ECGs fro...

journal_title：Circulation research

authors： Nearing BD,Verrier RL

更新日期：2002-10-18 00:00:00

abstract：:It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized ...

journal_title：Circulation research

authors： Seto S,Rabito SF,Scicli AG,Carretero OA

更新日期：1984-11-01 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：:Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive hormones. The identity of EDHF remains unknown. Since arachidonic acid causes endothelium-dependent relaxations of coronary arteries through it...

journal_title：Circulation research

authors： Campbell WB,Gebremedhin D,Pratt PF,Harder DR

更新日期：1996-03-01 00:00:00

abstract：:We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E-deficient (apoE-/-) mice treated with angiotensin II (Ang II). In the present study, we tested the hypothesis that uPA is essential for AAA form...

journal_title：Circulation research

authors： Deng GG,Martin-McNulty B,Sukovich DA,Freay A,Halks-Miller M,Thinnes T,Loskutoff DJ,Carmeliet P,Dole WP,Wang YX

更新日期：2003-03-21 00:00:00

abstract：:Pacemaker and conduction system myocytes play crucial roles in initiating and regulating the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging cause dysfunction of the pacemaker and conduction tissues, emphasizing the clinical necessity to understand the molecular and cellular mechanis...

journal_title：Circulation research

authors： Christoffels VM,Smits GJ,Kispert A,Moorman AF

更新日期：2010-02-05 00:00:00

abstract：:Five fetal sheep (gestational age, 118 to 125 days) were instrumented to measure impedances of the lower abdominal aorta. Four days after surgery, flow and pressure pulses were recorded during control conditions and during infusion of norepinephrine (0.3 to 3 micrograms.min-1.kg-1 body weight) or angiotensin II (0.2 t...

journal_title：Circulation research

authors： Schröder H,Cetin E,Hüneke B,Carstensen M

更新日期：1994-04-01 00:00:00

abstract：:Smooth muscle cell migration in response to platelet-derived growth factor (PDGF) is a key event in several vascular pathologies, including atherosclerosis and restenosis. PDGF increases intracellular levels of reactive oxygen species (ROS) in vascular smooth muscle cells (VSMCs), but the ROS sensitivity of migration ...

journal_title：Circulation research

authors： Weber DS,Taniyama Y,Rocic P,Seshiah PN,Dechert MA,Gerthoffer WT,Griendling KK

更新日期：2004-05-14 00:00:00

abstract：:AR-L 115BS, a benzimidazole derivative, is a positive inotropic agent that has been shown to increase active tension development and unloaded shortening velocity of chemically skinned heart muscle preparations at submaximal activating levels of free Ca++. We measured the effect of AR-L on relations between free Ca++, ...

journal_title：Circulation research

authors： Solaro RJ,Rüegg JC

更新日期：1982-09-01 00:00:00

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:Pinocytotic vesicles are one of several anatomic factors relevant to the permeability for macromolecules of capillary endothelia. We quantitified the number and distribution of pinocytotic vesicles present in the endothelium of pulmonary capillaries. Several similar studies have been reported in the past for endotheli...

journal_title：Circulation research

authors： Gil J,Silage DA

更新日期：1980-09-01 00:00:00

abstract：:Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filamen...

journal_title：Circulation research

authors： Tardiff JC

更新日期：2011-03-18 00:00:00

abstract：:Although the molecular effectors of apoptotic cell death have been largely annotated over the past 30 years, leading to a strong biological understanding of this process and its importance in cell biology, cell death through necrosis has only recently been accepted as a similarly regulated process with definable molec...

journal_title：Circulation research

authors： Karch J,Molkentin JD

更新日期：2015-05-22 00:00:00

abstract：:Mitochondria are an important source of reactive oxygen species (ROS), implicated in ischemia/reperfusion injury. When isolated from ischemic myocardium, mitochondria demonstrate increased ROS production as a result of damage to electron transport complexes. To investigate the mechanisms, we studied effects of hypoxia...

journal_title：Circulation research

authors： Korge P,Ping P,Weiss JN

更新日期：2008-10-10 00:00:00

abstract：:Inflammatory cell infiltration is a feature of postischemic neovascularization. However, mechanisms leading to leukocyte attraction to the site of neovascularization are still undefined. We hypothesized that the CXC chemokine receptor 3 (CXCR3) may contribute to leukocyte accumulation and subsequently to blood vessel ...

journal_title：Circulation research

authors： Waeckel L,Mallat Z,Potteaux S,Combadière C,Clergue M,Duriez M,Bao L,Gerard C,Rollins BJ,Tedgui A,Levy BI,Silvestre JS

更新日期：2005-03-18 00:00:00

abstract：:Cyclic nucleotides are known to modify voltage-gated (L-type) Ca2+ channel activity in vascular smooth muscle cells, but the exact mechanism(s) underlying these effects is not well defined. The purpose of the present study was to investigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and P...

journal_title：Circulation research

authors： Ruiz-Velasco V,Zhong J,Hume JR,Keef KD

更新日期：1998-03-23 00:00:00

abstract：:Net cellular L-lactate efflux associated with accelerated anaerobic glycolysis has been implicated as a potential cause of the marked cellular K+ loss contributing to lethal cardiac arrhythmias in ischemic heart and to impaired function of fatigued skeletal muscle. To examine the mechanisms of transsarcolemmal L-lacta...

journal_title：Circulation research

authors： Shieh RC,Goldhaber JI,Stuart JS,Weiss JN

更新日期：1994-05-01 00:00:00

abstract：:The influence of endothelin 1 on intracellular Ca2+ transients and isometric contractions was investigated in ferret papillary muscles loaded with the Ca(2+)-regulated bioluminescent indicator aequorin. In concentrations of 3 x 10(-9) to 1 x 10(-7) M, endothelin produced dose-dependent increases in the amplitudes of b...

journal_title：Circulation research

authors： Wang JX,Paik G,Morgan JP

更新日期：1991-09-01 00:00:00

abstract：RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. OBJECTIV...

journal_title：Circulation research

authors： Drews O,Tsukamoto O,Liem D,Streicher J,Wang Y,Ping P

更新日期：2010-10-29 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:The proteoglycan versican is implicated in several atherogenic events, including stimulation of vascular smooth muscle cell (VSMC) growth and migration, retention of lipoproteins, and promotion of thrombogenesis. A high content of intimal versican also correlates with a low content of elastin, suggesting an inhibitory...

journal_title：Circulation research

authors： Huang R,Merrilees MJ,Braun K,Beaumont B,Lemire J,Clowes AW,Hinek A,Wight TN

更新日期：2006-02-17 00:00:00