FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.

abstract：RATIONALE:Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. OBJECTIVE:The goal of this study was to assess whether genome editing using a clus...

journal_title：Circulation research

authors： Ding Q,Strong A,Patel KM,Ng SL,Gosis BS,Regan SN,Cowan CA,Rader DJ,Musunuru K

更新日期：2014-08-15 00:00:00

abstract：:To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded ...

journal_title：Circulation research

authors： Shimokawa H,Aarhus LL,Vanhoutte PM

更新日期：1987-08-01 00:00:00

abstract：:In pentobrabital-anesthetized open chest dogs, myocardial adenosine content is elevated by 5 or 15 seconds of left coronary artery occlusion and falls exponentially to control levels during reactive hyperemia. The rate constants for adenosine dissipation are (mean +/- SEM): -0.08 +/- 0.01 and -0.034 +/- 0.007 sec-1 af...

journal_title：Circulation research

authors： Olsson RA,Snow JA,Gentry MK

更新日期：1978-03-01 00:00:00

abstract：:Three models of altered autonomic innervation of the chick heart have been developed in the last few years. These include sympathetically aneural heart, parasympathetically aneural heart, and heart with cholinergic innervation reconstituted from the nodose placodes. The neural status of these hearts has been assessed ...

journal_title：Circulation research

authors： Kirby ML,Creazzo TL,Christiansen JL

更新日期：1989-12-01 00:00:00

abstract：:The relations between atrial natriuretic peptide (ANP) binding sites in the renal medulla, plasma ANP concentration, and ventricular dysfunction have been studied in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. Plasma ANP concentration was measured by radioimmunoassay, and quantit...

journal_title：Circulation research

authors： Tsunoda K,Mendelsohn FA,Sexton PM,Chai SY,Hodsman GP,Johnston CI

更新日期：1988-01-01 00:00:00

abstract：:Intracellular recordings were made from eustachian ridge of cat right atrium to determine mechanisms responsible for subsidiary pacemaker automaticity. Pacemaker action potentials exhibited two phases of diastolic depolarization: an initial steeper slope (D1) followed by a more gradual slope (D2). Cesium (1 mM) decrea...

journal_title：Circulation research

authors： Rubenstein DS,Lipsius SL

更新日期：1989-04-01 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：RATIONALE:Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an endoplasmic reticulum (ER)-transmembrane E3 ubiquitin ligase that has been studied in yeast, where it contributes to ER protein quality control by ER-associated degradation (ERAD) of misfolded proteins that accumulate during ER str...

journal_title：Circulation research

authors： Doroudgar S,Völkers M,Thuerauf DJ,Khan M,Mohsin S,Respress JL,Wang W,Gude N,Müller OJ,Wehrens XH,Sussman MA,Glembotski CC

更新日期：2015-08-28 00:00:00

abstract：:Cellular Ca2+ regulation is abnormal in diseased hearts. We designed this study to assess the role of the Na(+)-Ca2+ exchanger in excitation-contraction coupling in surviving myocardium of the infarcted heart. We measured cellular contractions and whole-cell currents in single left ventricular myocytes isolated from t...

journal_title：Circulation research

authors： Litwin SE,Bridge JH

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. OBJECTIVE:We sought to determine the role of AMPK (AMP-activated protein kinase) in selective ...

journal_title：Circulation research

authors： Wang B,Nie J,Wu L,Hu Y,Wen Z,Dong L,Zou MH,Chen C,Wang DW

更新日期：2018-03-02 00:00:00

abstract：RATIONALE:G protein-coupled receptor kinase 2 (GRK2) is abundantly expressed in the heart, and its expression and activity are increased in injured or stressed myocardium. This upregulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes, and its inhibition by a peptide comprising th...

journal_title：Circulation research

authors： Chen M,Sato PY,Chuprun JK,Peroutka RJ,Otis NJ,Ibetti J,Pan S,Sheu SS,Gao E,Koch WJ

更新日期：2013-04-12 00:00:00

abstract：:In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus node, using the microelectrode technique. After the electrophysiological experiments, the preparations were subjected to a correlative morphological investigation, using light or electron microscopy. Different criteria for ...

journal_title：Circulation research

authors： Bleeker WK,Mackaay AJ,Masson-Pévet M,Bouman LN,Becker AE

更新日期：1980-01-01 00:00:00

abstract：:We tested the hypothesis that a parenchymally derived mediator is required for arterioles to exhibit oxygen sensitivity. To that end, the parenchyma was dissected and removed from around hamster cheek pouch arterioles, and the oxygen sensitivity of these "aparenchymal arteriolar segments" was studied, either in vitro,...

journal_title：Circulation research

authors： Jackson WF,Duling BR

更新日期：1983-10-01 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：RATIONALE:In the myocardium, redox/cysteine modification of proteins regulating Ca(2+) cycling can affect contraction and may have therapeutic value. Nitroxyl (HNO), the one-electron-reduced form of nitric oxide, enhances cardiac function in a manner that suggests reversible cysteine modifications of the contractile ma...

journal_title：Circulation research

authors： Gao WD,Murray CI,Tian Y,Zhong X,DuMond JF,Shen X,Stanley BA,Foster DB,Wink DA,King SB,Van Eyk JE,Paolocci N

更新日期：2012-09-28 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:We tested the hypothesis that accumulation of H+ or inorganic phosphate (Pi) is responsible for the early contractile failure of hypoxia by measuring maximal Ca2+-activated pressure and 31P nuclear magnetic resonance spectra in Langendorff-perfused ferret hearts at 30 degrees C. Maximal Ca2+-activated pressure was ide...

journal_title：Circulation research

authors： Kusuoka H,Weisfeldt ML,Zweier JL,Jacobus WE,Marban E

更新日期：1986-09-01 00:00:00

abstract：:We sought to determine the ejection variables that are principally responsible for increases in isovolumic ventricular relaxation rate observed with increases in stroke volume. In nine isolated canine hearts, left ventricular ejection was controlled by patterns specially designed to isolate the ejection parameters mos...

journal_title：Circulation research

authors： Hori M,Kitakaze M,Ishida Y,Fukunami M,Kitabatake A,Inoue M,Kamada T,Yue DT

更新日期：1991-01-01 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:To investigate the dynamic control of cardiac ATP synthesis, we simultaneously determined the time course of mitochondrial oxygen consumption with the time course of changes in high-energy phosphates following steps in cardiac energy demand. Isolated isovolumically contracting rabbit hearts were perfused with Tyrode's...

journal_title：Circulation research

authors： Eijgelshoven MH,van Beek JH,Mottet I,Nederhoff MG,van Echteld CJ,Westerhof N

更新日期：1994-10-01 00:00:00

abstract：:We recorded 60 DC simultaneous electrograms from isolated porcine and canine hearts in the first minutes after coronary occlusion. Ventricular premature beats (VPB) originated from the normal side of the ischemic border, which was frequently separated from the central ischemic area showing delayed activity by a small ...

journal_title：Circulation research

authors： Janse MJ,van Capelle FJ

更新日期：1982-04-01 00:00:00

abstract：:The tyrosine phosphorylated protein Crk-associated substrate (CAS) has previously been shown to participate in the cellular processes regulating dynamic changes in the actin architecture and arterial constriction. In the present study, treatment of rat mesenteric arteries with phenylephrine (PE) led to the increase in...

journal_title：Circulation research

authors： Anfinogenova Y,Wang R,Li QF,Spinelli AM,Tang DD

更新日期：2007-08-17 00:00:00

abstract：:The ionic currents that cross the myocardial membrane during cardiac activation have a corresponding return path in the extracellular space. The transmembrane current (Im) during activation of cardiac cells in situ has previously been envisioned only in mathematical models. We have developed a remarkably simple in viv...

journal_title：Circulation research

authors： Witkowski FX,Kavanagh KM,Penkoske PA,Plonsey R

更新日期：1993-02-01 00:00:00

abstract：:By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) ...

journal_title：Circulation research

authors： Maruyama Y,Ashikawa K,Isoyama S,Kanatsuka H,Ino-Oka E,Takishima T

更新日期：1982-01-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:Arterial segments (less than 250 micron o.d.) excised from canine ileum were mounted in a chamber that permitted arterial transmural pressure (TMP) to be altered and measured. Subsequently, the periarterial nerves were field stimulated with single pulses (0.1 msec, 70 V), and the resting membrane potential (Em) as wel...

journal_title：Circulation research

authors： Smeda JS,Daniel EE

更新日期：1988-06-01 00:00:00

abstract：:The fluorescent dye 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF) was used to measure pHi in the spontaneously hypertensive rat (SHR) and in normal rat cardiac myocytes under nominally HCO3-free (20 mmol/L HEPES-buffered) conditions. When only the Na-H exchanger was blocked, the intrinsic buffering power (bet...

journal_title：Circulation research

authors： Wu ML,Tsai ML,Tseng YZ

更新日期：1994-07-01 00:00:00

abstract：:In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

journal_title：Circulation research

authors： Tohse N,Mészáros J,Sperelakis N

更新日期：1992-08-01 00:00:00

abstract：:Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriogr...

journal_title：Circulation research

authors： Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1992-03-01 00:00:00