In vivo estimation of cardiac transmembrane current.

abstract：:The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

journal_title：Circulation research

authors： Luo CH,Rudy Y

更新日期：1994-06-01 00:00:00

abstract：:Excitation-contraction coupling in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca²(+) transport. The complexity and integrative nature of heart cell electrophysiology and Ca²(+) cycling has led to an evolution of computational models that have played a crucial role in s...

journal_title：Circulation research

authors： Greenstein JL,Winslow RL

更新日期：2011-01-07 00:00:00

abstract：:Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or s...

journal_title：Circulation research

authors： Proctor KG,Bealer SL

更新日期：1987-07-01 00:00:00

abstract：:F2-Isoprostanes are novel bioactive prostaglandin F2-like compounds produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. F2-Isoprostanes are initially formed in situ on phospholipids and subsequently released. Quantification of the F2-isoprostanes has been found to represent a valuable and...

journal_title：Circulation research

authors： Moore KP,Darley-Usmar V,Morrow J,Roberts LJ 2nd

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear. OBJECTIVE:To determine how mitochond...

journal_title：Circulation research

authors： Shimasaki Y,Pan N,Messina LM,Li C,Chen K,Liu L,Cooper MP,Vita JA,Keaney JF Jr

更新日期：2013-09-13 00:00:00

abstract：RATIONALE:The sarcolemma of cardiomyocytes contains many proteins that are essential for electromechanical function in general, and excitation-contraction coupling in particular. The distribution of these proteins is nonuniform between the bulk sarcolemmal surface and membrane invaginations known as transverse tubules ...

journal_title：Circulation research

authors： Rog-Zielinska EA,Scardigli M,Peyronnet R,Zgierski-Johnston CM,Greiner J,Madl J,O'Toole ET,Morphew M,Hoenger A,Sacconi L,Kohl P

更新日期：2021-01-22 00:00:00

abstract：:The present study was performed to examine the mechanism by which cyclooxygenase blockade produces vasoconstriction in well-developed coronary collateral vessels. Eight dogs were studied 4 to 6 months after occlusion of the left anterior descending coronary artery (LAD) had been performed to stimulate collateral vesse...

journal_title：Circulation research

authors： Altman JD,Bache RJ

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:We studied the time-dependent changes in the response of heart rate (sinus cycle length) to 30-second trains of vagal stimulation (8 Hz), repeated every 2 minutes, in canine neonates aged 7.1 +/- 2.5 (mean +/- SD) days. The first vagal train prolonged the sinus cycle length by 58 +/- 35%, but the response was attenuat...

journal_title：Circulation research

authors： Yamasaki S,Stolfi A,Mas MS,Fox LS,Pickoff AS

更新日期：1991-08-01 00:00:00

abstract：:Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B). We determined whether UT-A proteins could be detected in heart and whether their abundance was altered by uremia or hypertension or in human heart failure. In normal rat heart, bands were detected at 56, 51, and 39 kDa. In uremic ra...

journal_title：Circulation research

authors： Duchesne R,Klein JD,Velotta JB,Doran JJ,Rouillard P,Roberts BR,McDonough AA,Sands JM

更新日期：2001-07-20 00:00:00

abstract：:To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

journal_title：Circulation research

authors： Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

更新日期：2002-04-05 00:00:00

abstract：:Pulsatile pulmonary hemodynamics were analyzed in a chronic awake canine high flow model. Standard mean flow and pulsatile flow hemodynamics were measured and alterations in the proximal pulmonary vascular physical properties were quantified by the characteristic impedance (Zo). Pulmonary vascular resistance (PVR), wh...

journal_title：Circulation research

authors： Hopkins RA,Hammon JW Jr,McHale PA,Smith PK,Anderson RW

更新日期：1979-08-01 00:00:00

abstract：:Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action pot...

journal_title：Circulation research

authors： Mitsuiye T,Shinagawa Y,Noma A

更新日期：2000-07-21 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：:Thrombin stimulates synthesis and secretion of endothelin-1 (ET-1), a vasoactive peptide that triggers responses in the vascular endothelium and smooth muscle. We investigated the signal transduction pathways by which thrombin stimulates preproET-1 gene expression and ET-1 peptide secretion in macrovascular cells (hum...

journal_title：Circulation research

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-06-01 00:00:00

abstract：:We examined the function of the interventricular septum in six open-chest dogs by inserting piezoelectric crystals into the interventricular septum. Continuous ultrasonic recordings showed that the changes in myocardial chord length (MCL) in the septum and free walls of the right and left ventricle were similar during...

journal_title：Circulation research

authors： Molaug M,Stokland O,Ilebekk A,Lekven J,Kiil F

更新日期：1981-07-01 00:00:00

abstract：:In studies that attempt to measure intracellular calcium [( Ca2+]i) in the intact heart with the calcium indicator indo 1-AM, a fundamental assumption is that the signals report changes in myocyte [Ca2+]i. We studied isolated perfused rabbit hearts loaded with the calcium probe indo 1-AM and recorded surface fluoresce...

journal_title：Circulation research

authors： Lorell BH,Apstein CS,Cunningham MJ,Schoen FJ,Weinberg EO,Peeters GA,Barry WH

更新日期：1990-08-01 00:00:00

abstract：:Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

journal_title：Circulation research

authors： Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

更新日期：1992-12-01 00:00:00

abstract：RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epicardial lineage durin...

journal_title：Circulation research

authors： van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ

更新日期：2009-08-28 00:00:00

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:Patients with diabetes mellitus have >2× the risk for developing heart failure (HF; HF with reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular outcomes, hospitalization, and prognosis are worse for patients with diabetes mellitus relative to those without. Beyond the structural and func...

journal_title：Circulation research

authors： Kenny HC,Abel ED

更新日期：2019-01-04 00:00:00

abstract：:Disorders of L-type Ca2+ channels can cause severe cardiac arrhythmias. A subclass of small GTP-binding proteins, the RGK family, regulates L-type Ca2+ current (I(Ca,L)) in heterologous expression systems. Among these proteins, Rad (Ras associated with diabetes) is highly expressed in the heart, although its role in t...

journal_title：Circulation research

authors： Yada H,Murata M,Shimoda K,Yuasa S,Kawaguchi H,Ieda M,Adachi T,Murata M,Ogawa S,Fukuda K

更新日期：2007-07-06 00:00:00

abstract：RATIONALE:A hallmark of chronic inflammatory disorders is persistence of proinflammatory macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia and oxidative stress, but mechanisms linking these phenomena to macrophage activation remain incompletely understood. OBJECTIVE:To investiga...

journal_title：Circulation research

authors： Chen Y,Yang M,Huang W,Chen W,Zhao Y,Schulte ML,Volberding P,Gerbec Z,Zimmermann MT,Zeighami A,Demos W,Zhang J,Knaack DA,Smith BC,Cui W,Malarkannan S,Sodhi K,Shapiro JI,Xie Z,Sahoo D,Silverstein RL

更新日期：2019-12-06 00:00:00

abstract：:Transient coronary occlusion (15 minutes) does not result in irreversible myocardial injury but is associated with a depression of contractile function sustained for several hours to days ("stunned myocardium"). The defect in the contractile process responsible for this phenomenon has been suggested to be causally rel...

journal_title：Circulation research

authors： Ito BR,Tate H,Kobayashi M,Schaper W

更新日期：1987-12-01 00:00:00

abstract：:The release of acetylcholine from autonomic nerves in those tissues that receive a cholinergic innervation is widely believed to dilate blood vessels. Exogenously administered acetylcholine in vivo does dilate vascular beds and produce hypotension; however, this latter effect is indirect and probably the result of lib...

journal_title：Circulation research

authors： Kalsner S

更新日期：1989-08-01 00:00:00

abstract：:In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor. In humans, aldosterone causes MR-dependent endothelial cell (EC) dysfunction...

journal_title：Circulation research

authors： Caprio M,Newfell BG,la Sala A,Baur W,Fabbri A,Rosano G,Mendelsohn ME,Jaffe IZ

更新日期：2008-06-06 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Recent studies have demonstrated that vascular smooth muscle cells are responsive to changes in their local hemodynamic environment. The effects of shear stress on the expression of human protease activated receptor-1 (PAR-1) and tissue plasminogen activator (tPA) mRNA and protein were investigated in human aortic smo...

journal_title：Circulation research

authors： Papadaki M,Ruef J,Nguyen KT,Li F,Patterson C,Eskin SG,McIntire LV,Runge MS

更新日期：1998-11-16 00:00:00

abstract：:The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular in...

journal_title：Circulation research

authors： Sandberg WJ,Halvorsen B,Yndestad A,Smith C,Otterdal K,Brosstad FR,Frøland SS,Olofsson PS,Damås JK,Gullestad L,Hansson GK,Oie E,Aukrust P

更新日期：2009-01-02 00:00:00

abstract：:T-wave alternans (TWA), an ABAB oscillation, has been postulated as the initial pattern in a stepwise progression to higher-order oscillations, culminating in sudden arrhythmic death. The present study is the first to provide experimental evidence to support this intriguing concept. Epicardial and endocardial ECGs fro...

journal_title：Circulation research

authors： Nearing BD,Verrier RL

更新日期：2002-10-18 00:00:00