Abstract:
RATIONALE:Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear. OBJECTIVE:To determine how mitochondria impact endothelial cell function. METHODS AND RESULTS:We report here that stimuli for endothelial cell proliferation evoke strong upregulation of mitochondrial uncoupling protein 2 (UCP2). Analysis in silico indicated increased UCP2 expression is common in highly proliferative cell types, including cancer cells. Upregulation of UCP2 was critical for controlling mitochondrial membrane potential (Δψ) and superoxide production. In the absence of UCP2, endothelial growth stimulation provoked mitochondrial network fragmentation and premature senescence via a mechanism involving superoxide-mediated p53 activation. Mitochondrial network fragmentation was both necessary and sufficient for the impact of UCP2 on endothelial cell phenotype. CONCLUSIONS:These data identify a novel mechanism whereby mitochondria preserve normal network integrity and impact cell phenotype via dynamic regulation of UCP2.
journal_name
Circ Resjournal_title
Circulation researchauthors
Shimasaki Y,Pan N,Messina LM,Li C,Chen K,Liu L,Cooper MP,Vita JA,Keaney JF Jrdoi
10.1161/CIRCRESAHA.113.301319subject
Has Abstractpub_date
2013-09-13 00:00:00pages
891-901issue
7eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.113.301319journal_volume
113pub_type
杂志文章abstract::The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix. Dystrophin, the protein product of the Duc...
journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.RES.0000126574.61061.25
更新日期:2004-04-30 00:00:00
abstract::This paper describes use of the Karhunen-Loeve expansion to identify and reduce temporal redundancy in electrocardiographic body surface potential maps (192 body surface leads recorded simultaneously at 1 kHz/channel for approximately 600 msec). Temporal data compression of about 20 to 1 was obtained with accurate rep...
journal_title:Circulation research
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更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Circulation research
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更新日期:2011-09-30 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.57.4.532
更新日期:1985-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2016-02-19 00:00:00
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journal_title:Circulation research
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
abstract::Many indices have been proposed to describee the diastolic pressure-volume curve mathematically and permit quantification of the elastic properties of the myocardium itself in hopes that changes in the muscle caused by disease would b.e reflected in the diastolic pressure-volume curve. To date, none of the proposed in...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.39.6.772
更新日期:1976-12-01 00:00:00
abstract::We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...
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更新日期:1991-12-01 00:00:00
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更新日期:1988-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1992-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.110.219089
更新日期:2010-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1976-07-01 00:00:00
abstract::We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...
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更新日期:2000-08-04 00:00:00
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pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
abstract:RATIONALE:Post-myocardial infarction ventricular remodeling is associated with the expression of a variety of factors including S100B that can potentially modulate myocyte apoptosis. OBJECTIVE:This study was undertaken to investigate the expression and function of S100B and its receptor, the receptor for advanced glyc...
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.195834
更新日期:2010-01-08 00:00:00
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更新日期:2012-08-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.110.238717
更新日期:2011-07-08 00:00:00
abstract::Rat lungs were inflated and incubated in either anionic or cationic ferritin, and alveolar and capillary basement membranes were examined by electron microscopy. Cationic ferritin bound to heparan sulfate proteoglycans on the external surface of the alveolar basement membrane, whereas cationic ferritin bound to the la...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.55.2.155
更新日期:1984-08-01 00:00:00
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journal_title:Circulation research
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更新日期:1994-06-01 00:00:00
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更新日期:2003-07-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.66.3.585
更新日期:1990-03-01 00:00:00