MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo.

abstract：:The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules likely to affect oxidase activity. We examined the ability of Ang II to stimulate superoxide anion formation and investigated...

journal_title：Circulation research

authors： Griendling KK,Minieri CA,Ollerenshaw JD,Alexander RW

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1-phosphate (S1P)-a highly enriched biolipid in erythrocytes-is recently reported to be induced under high altitude in normal humans to enhance O2 delivery...

journal_title：Circulation research

authors： Xie T,Chen C,Peng Z,Brown BC,Reisz JA,Xu P,Zhou Z,Song A,Zhang Y,Bogdanov MV,Kellems RE,D'Alessandro A,Zhang W,Xia Y

更新日期：2020-07-17 00:00:00

abstract：RATIONALE:The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholester...

journal_title：Circulation research

authors： Nelson JK,Sorrentino V,Avagliano Trezza R,Heride C,Urbe S,Distel B,Zelcer N

更新日期：2016-02-05 00:00:00

abstract：:Previous studies have suggested that intravenous infusion of arginine vasopressin (AVP) inhibits sympathetic nerve activity (SNA) in rabbits by its action at the brainstem. This study aimed to determine, first, whether this action of AVP depended on functioning baroreflex mechanisms. The second aim was to determine th...

journal_title：Circulation research

authors： Suzuki S,Takeshita A,Imaizumi T,Hirooka Y,Yoshida M,Ando S,Nakamura M

更新日期：1989-11-01 00:00:00

abstract：:Calcium channel blockers (CCBs), which are used clinically for treatment of angina and hypertension, are known to inhibit calcium influx into arterial smooth muscle cells and thereby decrease smooth muscle cell contraction. In addition, they prevent cholesteryl ester (CE) accumulation, the hallmark of human atheroscle...

journal_title：Circulation research

authors： Etingin OR,Hajjar DP

更新日期：1990-01-01 00:00:00

abstract：:The aim of the study was to investigate whether the adrenal renin-angiotensin system plays an independent role in the regulation of mineralocorticoid biosynthesis in the adrenal gland and to explore the mechanisms of this action. Twelve-week-old male Sprague-Dawley rats were studied: 22 rats were maintained on a regul...

journal_title：Circulation research

authors： Volpe M,Gigante B,Enea I,Porcellini A,Russo R,Lee MA,Magri P,Condorelli G,Savoia C,Lindpaintner K,Rubattu S

更新日期：1997-11-01 00:00:00

abstract：:We determined the extent of convergence of preganglionic fibers from the right and left vagus nerves on postganglionic neurons that supply the sinoatrial node in chloralose-anesthetized dogs. We administered hemicholinium-3 and stimulated the right vagus nerve at a high frequency to deplete acetylcholine from the post...

journal_title：Circulation research

authors： Lang SA,Zieske H,Levy MN

更新日期：1990-09-01 00:00:00

abstract：:Regional myocardial oxygenation was assessed during partial and complete coronary artery occlusion using near infrared spectroscopy. In eight open-chest dogs, partial occlusions resulting in an approximately 42% decrease in left anterior descending coronary artery (LAD) blood flow produced an approximately 21% decreas...

journal_title：Circulation research

authors： Parsons WJ,Rembert JC,Bauman RP,Duhaylongsod FG,Greenfield JC Jr,Piantadosi CA

更新日期：1993-09-01 00:00:00

abstract：RATIONALE:Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE:Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS:C57Bl6, Ace2 knockout (...

journal_title：Circulation research

authors： Thomas MC,Pickering RJ,Tsorotes D,Koitka A,Sheehy K,Bernardi S,Toffoli B,Nguyen-Huu TP,Head GA,Fu Y,Chin-Dusting J,Cooper ME,Tikellis C

更新日期：2010-10-01 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link is yet established between the vascular pathology of the metabolic syndrome with a particular inflammatory cytokine. We hypothesized that impairments in coronary endothelial function in the obese...

journal_title：Circulation research

authors： Picchi A,Gao X,Belmadani S,Potter BJ,Focardi M,Chilian WM,Zhang C

更新日期：2006-07-07 00:00:00

abstract：:The purpose of this study was to determine whether a cyclic adenosine 3',5'-monophosphate-dependent process can be involved in the regulation of vascular smooth muscle alpha 1-adrenergic receptor responsiveness. Experiments were performed in cultured rabbit aortic smooth muscle cells which were characterized previousl...

journal_title：Circulation research

authors： Colucci WS

更新日期：1986-02-01 00:00:00

abstract：:Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for increased ROS and to determine the contribution of superoxide anion (*O(2)(-)), H(2)O(2), and hydroxy radical (*OH) in failing myoca...

journal_title：Circulation research

authors： Ide T,Tsutsui H,Kinugawa S,Suematsu N,Hayashidani S,Ichikawa K,Utsumi H,Machida Y,Egashira K,Takeshita A

更新日期：2000-02-04 00:00:00

abstract：:Arterial segments (less than 250 micron o.d.) excised from canine ileum were mounted in a chamber that permitted arterial transmural pressure (TMP) to be altered and measured. Subsequently, the periarterial nerves were field stimulated with single pulses (0.1 msec, 70 V), and the resting membrane potential (Em) as wel...

journal_title：Circulation research

authors： Smeda JS,Daniel EE

更新日期：1988-06-01 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) are short noncoding RNA species generated by the processing of longer precursors by the ribonucleases Drosha and Dicer. Platelets contain large amounts of miRNA that are altered by disease, in particular diabetes mellitus. OBJECTIVE:This study determined why platelet miRNA levels are atten...

journal_title：Circulation research

authors： Elgheznawy A,Shi L,Hu J,Wittig I,Laban H,Pircher J,Mann A,Provost P,Randriamboavonjy V,Fleming I

更新日期：2015-07-03 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：:The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether sphingolipid metabolism can account for mediating MAO-A- and reactive oxygen species-depend...

journal_title：Circulation research

authors： Pchejetski D,Kunduzova O,Dayon A,Calise D,Seguelas MH,Leducq N,Seif I,Parini A,Cuvillier O

更新日期：2007-01-05 00:00:00

abstract：:The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to exhibit large conductance calcium channel activity. High molecular weight proteins were solubilized from junctional sarcoplasmic reticulum in zwitterionic detergent ...

journal_title：Circulation research

authors： Rardon DP,Cefali DC,Mitchell RD,Seiler SM,Jones LR

更新日期：1989-04-01 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：RATIONALE:Slow nonuniform electric propagation in the border zone (BZ) of a healed myocardial infarct (MI) can give rise to reentrant arrhythmia. The extent to which this is influenced by structural rather than cellular electric remodeling is unclear. OBJECTIVE:To determine whether structural remodeling alone in the i...

journal_title：Circulation research

authors： Rutherford SL,Trew ML,Sands GB,LeGrice IJ,Smaill BH

更新日期：2012-07-20 00:00:00

abstract：:Platelet activation is markedly increased during coronary thrombolysis and limits the response to thrombolytic therapy. A possible mediator of platelet activation in this setting is thromboxane (TX) A2, a potent platelet agonist formed in greatly increased amounts during coronary thrombolysis in man. To address this h...

journal_title：Circulation research

authors： Fitzgerald DJ,Wright F,FitzGerald GA

更新日期：1989-07-01 00:00:00

abstract：:The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium i...

journal_title：Circulation research

authors： Schiebinger RJ

更新日期：1989-09-01 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:The smooth muscle myosin heavy chain (SM-MHC) gene encodes a major contractile protein whose expression exclusively marks the smooth muscle cell (SMC) lineage. To better understand smooth muscle differentiation at the transcriptional level, we have initiated studies to identify those DNA sequences critical for express...

journal_title：Circulation research

authors： Madsen CS,Regan CP,Hungerford JE,White SL,Manabe I,Owens GK

更新日期：1998-05-04 00:00:00

abstract：:A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase calcineurin as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in left ventricular hypertrophy (LVH). Most of the recent experimental support for this hypothesis is derived fro...

journal_title：Circulation research

authors： Zhang W,Kowal RC,Rusnak F,Sikkink RA,Olson EN,Victor RG

更新日期：1999-04-02 00:00:00

abstract：RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation. OBJECTIVE:We hypothesized that YAP activation after myocardial infarction (MI) would preserve cardiac function and improve survival. METHODS AND RESULTS:We use...

journal_title：Circulation research

authors： Lin Z,von Gise A,Zhou P,Gu F,Ma Q,Jiang J,Yau AL,Buck JN,Gouin KA,van Gorp PR,Zhou B,Chen J,Seidman JG,Wang DZ,Pu WT

更新日期：2014-07-18 00:00:00

abstract：:Atherosclerosis is considered to be an inflammatory disease. Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque rupture. Recent studies suggest that the antiinflammatory cyt...

journal_title：Circulation research

authors： Kamimura M,Viedt C,Dalpke A,Rosenfeld ME,Mackman N,Cohen DM,Blessing E,Preusch M,Weber CM,Kreuzer J,Katus HA,Bea F

更新日期：2005-08-19 00:00:00

abstract：:The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates optimal force transduction, electric transmission, intercellular communication, and metabolic exchange within the myocardial microenvir...

journal_title：Circulation research

authors： Li AH,Liu PP,Villarreal FJ,Garcia RA

更新日期：2014-02-28 00:00:00