Dynamic changes in myocardial matrix and relevance to disease: translational perspectives.

abstract：:Myocardial stunning is a form of reversible myocardial ischemia/reperfusion injury associated with systolic and diastolic contractile dysfunction. In the isolated rat heart model, myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...

journal_title：Circulation research

authors： Foster DB,Noguchi T,VanBuren P,Murphy AM,Van Eyk JE

更新日期：2003-11-14 00:00:00

abstract：:Myocytes overlying a zone of infarction form the primary substrate for serious reentrant ventricular arrhythmias. In vitro and in vivo studies suggest that antiarrhythmic agents affect Na+ channels of cells from the epicardial border zone (EBZ) of the 5-day infarcted heart differently than they affect those of normal ...

journal_title：Circulation research

authors： Pu J,Balser JR,Boyden PA

更新日期：1998-08-24 00:00:00

abstract：:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive tri...

journal_title：Circulation research

authors： Perino A,Ghigo A,Scott JD,Hirsch E

更新日期：2012-08-03 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a widely distributed mitogen that mediates the growth-promoting effects of platelet-derived growth factor in mesenchymal cells. We show that rat aortic IGF-I messenger RNA (mRNA) is induced 24 hours after deendothelialization, at a time when smooth muscle cell proliferation with...

journal_title：Circulation research

authors： Cercek B,Fishbein MC,Forrester JS,Helfant RH,Fagin JA

更新日期：1990-06-01 00:00:00

abstract：:Angiotensin II (Ang II) plays an important role in post-myocardial infarction (MI) remodeling. Most Ang II effects related to remodeling involve activation of the type 1 receptor (AT(1)). Although the AT(1) receptor is upregulated on cardiac fibroblasts post-MI, little is known about the mechanisms involved in the pro...

journal_title：Circulation research

authors： Gurantz D,Cowling RT,Villarreal FJ,Greenberg BH

更新日期：1999-08-06 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：:A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

journal_title：Circulation research

authors： Tada M,Kirchberger MA,Iorio JM,Katz AM

更新日期：1975-01-01 00:00:00

abstract：RATIONALE:Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications controlling its activation. OBJECTIVE:To determine whether posttran...

journal_title：Circulation research

authors： Streeter J,Schickling BM,Jiang S,Stanic B,Thiel WH,Gakhar L,Houtman JC,Miller FJ Jr

更新日期：2014-11-07 00:00:00

abstract：:Sinus node recovery time was compared to the recovery time of a slow atrioventricular junctional rhythm in each of the same seven pentobarbital anesthetized dogs. Recovery time and the first five cardiac cycles were examined after pacing atria and ventricles for 20, 40, and 60 seconds at four or more pacing cycle leng...

journal_title：Circulation research

authors： Neely BH,Urthaler F,Hageman GR

更新日期：1985-07-01 00:00:00

abstract：:Previously, we have reported on the selective accumulation of an atrial-like myosin light chain-1 (ALC1) in different forms of human ventricular hypertrophy. The present study involves the determination of ALC1 content in a control group and in patients with aortic stenosis or insufficiency before and 56 +/- 23 months...

journal_title：Circulation research

authors： Sütsch G,Brunner UT,von Schulthess C,Hirzel HO,Hess OM,Turina M,Krayenbuehl HP,Schaub MC

更新日期：1992-05-01 00:00:00

abstract：RATIONALE:Studies have demonstrated that exosomes can repair cardiac tissue post-myocardial infarction and recapitulate the benefits of cellular therapy. OBJECTIVE:We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion inj...

journal_title：Circulation research

authors： Agarwal U,George A,Bhutani S,Ghosh-Choudhary S,Maxwell JT,Brown ME,Mehta Y,Platt MO,Liang Y,Sahoo S,Davis ME

更新日期：2017-02-17 00:00:00

abstract：RATIONALE:Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1-phosphate (S1P)-a highly enriched biolipid in erythrocytes-is recently reported to be induced under high altitude in normal humans to enhance O2 delivery...

journal_title：Circulation research

authors： Xie T,Chen C,Peng Z,Brown BC,Reisz JA,Xu P,Zhou Z,Song A,Zhang Y,Bogdanov MV,Kellems RE,D'Alessandro A,Zhang W,Xia Y

更新日期：2020-07-17 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kappaB to apoptosis, it is still controversial. Especially, the r...

journal_title：Circulation research

authors： Matsushita H,Morishita R,Nata T,Aoki M,Nakagami H,Taniyama Y,Yamamoto K,Higaki J,Yasufumi K,Ogihara T

更新日期：2000-05-12 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:The aim was to identify energy-consuming processes, other than contraction, downregulated during moderate hypoxia ( approximately 5 micromol/L, 0.5% O(2)) and severe hypoxia (<0.5 micromol/L, <0.05% O(2)) in isolated neonatal cardiomyocytes. The metabolic response of cardiomyocytes to moderate and severe hypoxia was a...

journal_title：Circulation research

authors： Casey TM,Pakay JL,Guppy M,Arthur PG

更新日期：2002-04-19 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic...

journal_title：Circulation research

authors： Zhang P,Xu X,Hu X,van Deel ED,Zhu G,Chen Y

更新日期：2007-04-13 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-no...

journal_title：Circulation research

authors： Tian Q,Kaestner L,Lipp P

更新日期：2012-06-22 00:00:00

abstract：RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE:This study sought to explore the premise that ...

journal_title：Circulation research

authors： Davidson MT,Grimsrud PA,Lai L,Draper JA,Fisher-Wellman KH,Narowski TM,Abraham DM,Koves TR,Kelly DP,Muoio DM

更新日期：2020-09-25 00:00:00

abstract：RATIONALE:The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined structures including central components and a peripheral Purkinje fiber network. How the mammalian ven...

journal_title：Circulation research

authors： Miquerol L,Moreno-Rascon N,Beyer S,Dupays L,Meilhac SM,Buckingham ME,Franco D,Kelly RG

更新日期：2010-07-09 00:00:00

abstract：:A period of prolonged vasodilation follows flow-restricted exercise of skeletal muscle. We tested the hypothesis that adenosine participates in mediating this vascular response. Vascularly isolated, anterior calf muscles of anesthetized dogs were stimulated to contract at a rate of 4 twitches/sec. Blood flow was held ...

journal_title：Circulation research

authors： Belloni FL,Phair RD,Sparks HV

更新日期：1979-06-01 00:00:00

abstract：:Whole-cell Ca2+ channel currents were recorded from isolated single canine Purkinje and ventricular cells to determine whether there were multiple types of Ca2+ channels in these two cell types, as in many other excitable tissues. The experimental conditions were such that currents other than Ca2+ channel currents wer...

journal_title：Circulation research

authors： Tseng GN,Boyden PA

更新日期：1989-12-01 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:In vivo studies of the rheological behavior of blood in the microcirculation were conducted by direct in situ measurements in cat mesentery. Upstream to downstream pressure drops were measured in unbranched arterioles, capillaries, and venules, with diameters from 7 to 58 micrometer. Simultaneous measurements of red c...

journal_title：Circulation research

authors： Lipowsky HH,Kovalcheck S,Zweifach BW

更新日期：1978-11-01 00:00:00

abstract：:A specific difference-spectrophotometric method was used to measure nitric oxide (NO) release into the coronary effluent perfusate of isolated, constant-flow-perfused guinea pig hearts. Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cy...

journal_title：Circulation research

authors： Kelm M,Schrader J

更新日期：1990-06-01 00:00:00

abstract：:Vascular endothelial cells are constantly exposed to mechanical forces resulting from blood flow and transmural pressure. The goal of this study was to determine whether mechanical stimulation alters the properties of endothelial voltage-gated K+ channels. Cardiac microvascular endothelial cells (CMECs) were isolated ...

journal_title：Circulation research

authors： Fan J,Walsh KB

更新日期：1999-03-05 00:00:00