C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning.

abstract：RATIONALE:Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important ...

journal_title：Circulation research

authors： Glukhov AV,Fedorov VV,Lou Q,Ravikumar VK,Kalish PW,Schuessler RB,Moazami N,Efimov IR

更新日期：2010-03-19 00:00:00

abstract：:Previous studies have demonstrated that low shear rates promote leukocyte adherence to microvascular endothelium in postcapillary venules. The objective of this study was to determine whether an accumulation of inflammatory mediators such as platelet activating factor and leukotriene B4 is responsible for shear rate-d...

journal_title：Circulation research

authors： Bienvenu K,Russell J,Granger DN

更新日期：1992-10-01 00:00:00

abstract：:Modulation of the inward Na+ current (I(Na)) by protein kinase C (PKC) was investigated by intracellular perfusion of a peptide corresponding to the catalytic subunit of PKC (PKCP). The effects of PKC activation independent of membrane-receptor pathways were studied in neonatal rat ventricular myocytes using whole-cel...

journal_title：Circulation research

authors： Watson CL,Gold MR

更新日期：1997-09-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes...

journal_title：Circulation research

authors： Schmidt AM,Yan SD,Wautier JL,Stern D

更新日期：1999-03-19 00:00:00

abstract：:Pyridine nucleotides are abundant soluble coenzymes and they undergo reversible oxidation and reduction in several biological electron-transfer reactions. They are comprised of two mononucleotides, adenosine monophosphate and nicotinamide mononucleotide, and are present as oxidized and reduced nicotinamide adenine din...

journal_title：Circulation research

authors： Nakamura M,Bhatnagar A,Sadoshima J

更新日期：2012-08-17 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic...

journal_title：Circulation research

authors： Zhang P,Xu X,Hu X,van Deel ED,Zhu G,Chen Y

更新日期：2007-04-13 00:00:00

abstract：:Platelet activation is markedly increased during coronary thrombolysis and limits the response to thrombolytic therapy. A possible mediator of platelet activation in this setting is thromboxane (TX) A2, a potent platelet agonist formed in greatly increased amounts during coronary thrombolysis in man. To address this h...

journal_title：Circulation research

authors： Fitzgerald DJ,Wright F,FitzGerald GA

更新日期：1989-07-01 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:Heterozygous familial hypercholesterolemia (FH) is a highly atherogenic genetic disorder leading to premature coronary heart disease (CHD), usually before 60 years of age. We studied an extended multigenerational kindred with FH linked to chromosome 1p32 in which atherosclerotic complications were either delayed or pr...

journal_title：Circulation research

authors： Canizales-Quinteros S,Aguilar-Salinas CA,Reyes-Rodríguez E,Riba L,Rodríguez-Torres M,Ramírez-Jiménez S,Huertas-Vázquez A,Fragoso-Ontiveros V,Zentella-Dehesa A,Ventura-Gallegos JL,Vega-Hernández G,López-Estrada A,Aurón-Gómez M,G

更新日期：2003-03-21 00:00:00

abstract：:Transforming growth factor (TGF)-beta plays a major role in the development of vascular diseases. Despite the pleiotropic effects of TGF-ss on vascular smooth muscle cells (VSMCs), only a few genes have been characterized as direct targets of TGF-beta in VSMCs. Cardiac ankyrin repeat protein (CARP) has been thought to...

journal_title：Circulation research

authors： Kanai H,Tanaka T,Aihara Y,Takeda S,Kawabata M,Miyazono K,Nagai R,Kurabayashi M

更新日期：2001-01-19 00:00:00

abstract：:Electrical uncoupling at gap junctions during acute myocardial ischemia contributes to conduction abnormalities and reentrant arrhythmias. Increased levels of intracellular Ca(2+) and H(+) and accumulation of amphipathic lipid metabolites during ischemia promote uncoupling, but other mechanisms may play a role. We tes...

journal_title：Circulation research

authors： Beardslee MA,Lerner DL,Tadros PN,Laing JG,Beyer EC,Yamada KA,Kléber AG,Schuessler RB,Saffitz JE

更新日期：2000-10-13 00:00:00

abstract：:Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to suppo...

journal_title：Circulation research

authors： Weber S,Bernhard D,Lukowski R,Weinmeister P,Wörner R,Wegener JW,Valtcheva N,Feil S,Schlossmann J,Hofmann F,Feil R

更新日期：2007-11-26 00:00:00

abstract：:Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

journal_title：Circulation research

authors： Morff RJ,Granger HJ

更新日期：1982-07-01 00:00:00

abstract：:Nitric oxide (NO), generated by platelets through stimulation of nitric oxide synthase (NOS), limits platelet adhesion and aggregation after a prothrombotic stimulus. Platelet beta-adrenoceptors (betaARs) mediate inhibition of aggregation, but no direct link has been shown between these receptors and platelet adhesion...

journal_title：Circulation research

authors： Queen LR,Xu B,Horinouchi K,Fisher I,Ferro A

更新日期：2000-07-07 00:00:00

abstract：:The use of risk markers has transformed cardiovascular medicine, exemplified by the routine assessment of troponin, for both diagnosis and assessment of prognosis in patients with chest pain. Clinical risk factors form the basis for risk assessment of cardiovascular disease and the addition of biochemical, cellular, a...

journal_title：Circulation research

authors： Thomas MR,Lip GY

更新日期：2017-01-06 00:00:00

abstract：RATIONALE:Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca(2+)-dependent multi-effector phosphatase. Calcineurin inhibitors such as cyclosporine A (CsA) were shown to be effe...

journal_title：Circulation research

authors： Yu H,Bot I,Sliedregt K,Xu X,Bot M,van Heiningen SH,van der Marel GA,Bennett MR,Overkleeft H,van Berkel TJ,Biessen EA

更新日期：2012-01-20 00:00:00

abstract：:Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. I...

journal_title：Circulation research

authors： Ryoo S,Gupta G,Benjo A,Lim HK,Camara A,Sikka G,Lim HK,Sohi J,Santhanam L,Soucy K,Tuday E,Baraban E,Ilies M,Gerstenblith G,Nyhan D,Shoukas A,Christianson DW,Alp NJ,Champion HC,Huso D,Berkowitz DE

更新日期：2008-04-25 00:00:00

abstract：:Despite the absence of a systematic development plan, β-blockers have reached the top tier of medical therapies for chronic heart failure. The successful outcome was due to the many dedicated investigators who produced, over a 30-year period, increasing evidence that β-blocking agents should or actually did improve th...

journal_title：Circulation research

authors： Bristow MR

更新日期：2011-10-28 00:00:00

abstract：:Two gap junction proteins, connexin43 (Cx43) and connexin45 (Cx45), are coexpressed in many cardiac and other cells. Homomeric channels formed by these proteins differ in unitary conductance, permeability, and regulation. We sought to determine the ability of Cx43 and Cx45 to oligomerize with each other to form hetero...

journal_title：Circulation research

authors： Martinez AD,Hayrapetyan V,Moreno AP,Beyer EC

更新日期：2002-05-31 00:00:00

abstract：RATIONALE:The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting fibrosis and ...

journal_title：Circulation research

authors： Russo I,Cavalera M,Huang S,Su Y,Hanna A,Chen B,Shinde AV,Conway SJ,Graff J,Frangogiannis NG

更新日期：2019-04-12 00:00:00

abstract：RATIONALE:Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an endoplasmic reticulum (ER)-transmembrane E3 ubiquitin ligase that has been studied in yeast, where it contributes to ER protein quality control by ER-associated degradation (ERAD) of misfolded proteins that accumulate during ER str...

journal_title：Circulation research

authors： Doroudgar S,Völkers M,Thuerauf DJ,Khan M,Mohsin S,Respress JL,Wang W,Gude N,Müller OJ,Wehrens XH,Sussman MA,Glembotski CC

更新日期：2015-08-28 00:00:00

abstract：:Volume densities of mitochondria, myofibrils, and unspecified cytoplasm were measured by ultrastructural morphometry in myocardium from dogs, rats, hamsters, mice, and in biopsied tissue from human hearts. Human myocardium was composed of 23% mitochondria, 59% myofibrils, and 18% cytoplasm. Volume densities for mitoch...

journal_title：Circulation research

authors： Schaper J,Meiser E,Stämmler G

更新日期：1985-03-01 00:00:00

abstract：:This study aimed to characterize the interaction between nitric oxide (NO)- and cAMP-related pathways in the control of renal blood flow. Using the isolated perfused rat kidney model, we determined the effects of inhibition of NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME; 1 mmol/L) and of NO administra...

journal_title：Circulation research

authors： Sandner P,Kornfeld M,Ruan X,Arendshorst WJ,Kurtz A

更新日期：1999-02-05 00:00:00

abstract：:Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality b...

journal_title：Circulation research

authors： West J,Fagan K,Steudel W,Fouty B,Lane K,Harral J,Hoedt-Miller M,Tada Y,Ozimek J,Tuder R,Rodman DM

更新日期：2004-04-30 00:00:00

abstract：:L-type Ca(2+) channel (LTCC) blockers, represented by amlodipine and verapamil, are widely used antihypertensive drugs that also have antiinflammatory activities. Plasminogen (Plg) is an important mediator of macrophage recruitment, and this role depends on its interaction with Plg receptors (Plg-Rs). Plg-Rs include h...

journal_title：Circulation research

authors： Das R,Burke T,Van Wagoner DR,Plow EF

更新日期：2009-07-17 00:00:00

abstract：:The smooth muscle myosin heavy chain (SM-MHC) gene encodes a major contractile protein whose expression exclusively marks the smooth muscle cell (SMC) lineage. To better understand smooth muscle differentiation at the transcriptional level, we have initiated studies to identify those DNA sequences critical for express...

journal_title：Circulation research

authors： Madsen CS,Regan CP,Hungerford JE,White SL,Manabe I,Owens GK

更新日期：1998-05-04 00:00:00

abstract：:Understanding the molecular interactions among components of cardiac Z-discs and their role in signaling has become pivotal in explaining long- and short-term regulation of cardiac function. In striated muscle, the ends of the thin filaments from opposing sarcomeres overlap and are cross-linked by an elaborate array o...

journal_title：Circulation research

authors： Pyle WG,Solaro RJ

更新日期：2004-02-20 00:00:00

abstract：RATIONALE:In the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation myocardial infarction and left ventricular (LV) dysfunction after successf...

journal_title：Circulation research

authors： Achilli F,Pontone G,Bassetti B,Squadroni L,Campodonico J,Corrada E,Facchini C,Mircoli L,Esposito G,Scarpa D,Pidello S,Righetti S,Di Gennaro F,Guglielmo M,Muscogiuri G,Baggiano A,Limido A,Lenatti L,Di Tano G,Malafron

更新日期：2019-07-19 00:00:00

abstract：:The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

journal_title：Circulation research

authors： Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

更新日期：1977-08-01 00:00:00

abstract：:Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial perme...

journal_title：Circulation research

authors： Weiss JN,Korge P,Honda HM,Ping P

更新日期：2003-08-22 00:00:00