Abstract:
:Understanding the molecular interactions among components of cardiac Z-discs and their role in signaling has become pivotal in explaining long- and short-term regulation of cardiac function. In striated muscle, the ends of the thin filaments from opposing sarcomeres overlap and are cross-linked by an elaborate array of proteins to form a highly ordered, yet dynamic network that is the Z-disc. We review here a current picture of the function and structure of the Z-disc of mammalian cardiac myocytes. We emphasize provocative findings that advance new theories about the place of cardiac Z-discs in myocardial intra- and intercellular signaling in myocardial physiology and pathology. Relatively new approaches, especially yeast two-hybrid screens, immunoprecipitation, and pull down assays, as well as immunohistochemical analysis have significantly altered previous views of the protein content of the Z-disc. These studies have generally defined domain structure and binding partners for Z-disc proteins, but the functional significance of the binding network and of the domains in cardiac cell biology remains an unfolding story. Yet, even at the present level of understanding, perceptions of potential functions of the Z-disc proteins are expanding greatly and leading to new and exciting experimental approaches toward mechanistic understanding. The theme of the following discussion of these Z-disc proteins centers on their potential to function not only as a physical anchor for myofilament and cytoskeletal proteins, but also as a pivot for reception, transduction, and transmission of mechanical and biochemical signals.
journal_name
Circ Resjournal_title
Circulation researchauthors
Pyle WG,Solaro RJdoi
10.1161/01.RES.0000116143.74830.A9subject
Has Abstractpub_date
2004-02-20 00:00:00pages
296-305issue
3eissn
0009-7330issn
1524-4571pii
94/3/296journal_volume
94pub_type
杂志文章,评审abstract::Blocking brain mineralocorticoid receptors (MRs) reduces the high circulating levels of tumor necrosis factor (TNF)-alpha in heart failure (HF) rats. TNF-alpha and other proinflammatory cytokines activate neurons in the paraventricular nucleus (PVN) of hypothalamus, including corticotropin-releasing hormone (CRH) neur...
journal_title:Circulation research
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更新日期:2004-05-14 00:00:00
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更新日期:1998-07-27 00:00:00
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更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1161/01.res.83.9.916
更新日期:1998-11-02 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-06-20 00:00:00
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更新日期:2016-02-19 00:00:00
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更新日期:1978-03-01 00:00:00
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更新日期:1991-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1975-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-08-16 00:00:00
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更新日期:2011-12-09 00:00:00
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更新日期:2016-04-15 00:00:00
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更新日期:2002-11-29 00:00:00