Abstract:
:This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Sixteen months later, we recorded the pressure gradient across the limb collaterals and measured blood flow with microspheres. Collateral conductance was fivefold greater after chronic ligation of the iliac artery than after acute ligation. Despite dilatation or growth of collateral vessels after chronic ligation, iliac pressure was reduced distal to the ligation. Blood flow to the limb was normal after chronic ligation in both normal and atherosclerotic monkeys. Collateral vessels constricted in response to infusion of phenylephrine and serotonin in normal and atherosclerotic monkeys. Thus, one conclusion of this study is that collateral vessels restore limb blood flow to normal after chronic vascular occlusion in both normal and atherosclerotic monkeys, but the protective effects of collateral vessels may be compromised by vasoconstrictor stimuli. Morphometric measurements indicated that occlusion of the iliac artery reduced proliferation of atherosclerotic intima distal to the occlusion in the cholesterol-fed monkeys. Thus, a second conclusion of this study is that atherosclerosis is attenuated below an arterial occlusion.
journal_name
Circ Resjournal_title
Circulation researchauthors
Lopez JA,Armstrong ML,Harrison DG,Piegors DJ,Heistad DDdoi
10.1161/01.res.63.6.1020subject
Has Abstractpub_date
1988-12-01 00:00:00pages
1020-8issue
6eissn
0009-7330issn
1524-4571journal_volume
63pub_type
杂志文章abstract::In myocardial infarction (MI), granulation tissue cells disappear via apoptosis to complete a final scarring with scanty cells. Blockade of this apoptosis was reported to improve post-MI ventricular remodeling and heart failure. However, the molecular biological mechanisms for the apoptosis are unknown. Fas and Fas li...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000141528.54850.bd
更新日期:2004-09-17 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-21 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.69.6.1608
更新日期:1991-12-01 00:00:00
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journal_title:Circulation research
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更新日期:2003-11-28 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.83.12.1232
更新日期:1998-12-14 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.42.4.529
更新日期:1978-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-06-14 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2003-07-25 00:00:00
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doi:10.1161/01.res.61.3.409
更新日期:1987-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-09-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2007-11-26 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.37.3.318
更新日期:1975-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2014-11-07 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.36.6.10
更新日期:1975-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000207407.51752.3c
更新日期:2006-03-17 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.77.6.1087
更新日期:1995-12-01 00:00:00
abstract::Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 ta...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000232324.87983.4b
更新日期:2006-07-07 00:00:00
abstract::Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and...
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pub_type: 杂志文章
doi:10.1161/01.RES.0000102937.50486.1B
更新日期:2003-11-28 00:00:00
abstract::Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.83.3.279
更新日期:1998-08-10 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.1.300
更新日期:1991-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.39.4.558
更新日期:1976-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.172619
更新日期:2008-08-15 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.65.4.1151
更新日期:1989-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.59.3.256
更新日期:1986-09-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2002-02-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.70.3.593
更新日期:1992-03-01 00:00:00
abstract::The aim was to identify energy-consuming processes, other than contraction, downregulated during moderate hypoxia ( approximately 5 micromol/L, 0.5% O(2)) and severe hypoxia (<0.5 micromol/L, <0.05% O(2)) in isolated neonatal cardiomyocytes. The metabolic response of cardiomyocytes to moderate and severe hypoxia was a...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000015592.95986.03
更新日期:2002-04-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.261768
更新日期:2012-06-08 00:00:00