Abstract:
:In pentobrabital-anesthetized open chest dogs, myocardial adenosine content is elevated by 5 or 15 seconds of left coronary artery occlusion and falls exponentially to control levels during reactive hyperemia. The rate constants for adenosine dissipation are (mean +/- SEM): -0.08 +/- 0.01 and -0.034 +/- 0.007 sec-1 after 5- and 15-second occlusion, respectively. Kinetic analysis of the reactive hyperemia flow curves (Circ Res 14/15 (suppl I): 81-85, 1963) predicts rates of -0.069 +/- 0.009 sec-1 and -0.04 +/- 0.009 sec-1, indicating that changes in adenosine levels can account for the way coronary flow changes during this response. The log (dose-) response curve relating reactive hyperemia flow to tissue adenosine concentration has a steeper slope and is half-maximal at a lower adenosine concentration than the dose-response curve obtained by intracoronary infusions of adenosine in oxygenated hearts, indicating that the coronary vasoactivity of adenosine is enhanced during reactive hyperemia. This could explain why theophylline antagonizes the coronary vasocilatory effect of adenosine in oxygenated hearts but has relatively little effect on reactive hyperemia.
journal_name
Circ Resjournal_title
Circulation researchauthors
Olsson RA,Snow JA,Gentry MKdoi
10.1161/01.res.42.3.358subject
Has Abstractpub_date
1978-03-01 00:00:00pages
358-62issue
3eissn
0009-7330issn
1524-4571journal_volume
42pub_type
杂志文章abstract::To elucidate the local effects of renin in the coronary circulation, we examined local angiotensin (Ang) I and II formation, as well as coronary vasoconstriction in response to renin administration, and compared the effects with exogenous infused Ang I. We perfused isolated hearts from rats overexpressing the human an...
journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-09-12 00:00:00
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pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
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更新日期:1989-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1976-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2006-10-27 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-09-14 00:00:00
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journal_title:Circulation research
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCRESAHA.115.304458
更新日期:2014-10-24 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1979-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1991-03-01 00:00:00
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更新日期:1977-02-01 00:00:00
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更新日期:2003-06-13 00:00:00
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更新日期:2001-03-02 00:00:00
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更新日期:2020-07-17 00:00:00
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-04-28 00:00:00
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更新日期:2014-10-10 00:00:00
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更新日期:2021-01-22 00:00:00
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更新日期:2012-07-20 00:00:00