Synthesis and pharmacology of a noncompetitive antagonist of angiotensin-induced contractions of vascular smooth muscle. [Sarcosyl]1-[cysteinyl (s-methyl)]8-angiotensin II.

abstract：:Freshly dispersed rabbit ear artery cells were studied using patch-clamp techniques to measure membrane currents in whole cells and single-channel currents in membrane patches. Whole-cell calcium currents recorded at physiologic extracellular calcium concentrations were small (approximately 10 pA). Recordings with 110...

journal_title：Circulation research

authors： Benham CD,Hess P,Tsien RW

更新日期：1987-10-01 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：:Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

journal_title：Circulation research

authors： Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

更新日期：2000-11-10 00:00:00

abstract：:Acute increases in arterial pulsatile load imposed on the left ventricle can increase coronary flow without commensurate changes in myocardial oxygen consumption. One explanation is that augmenting pulsatile perfusion at the same mean pressure itself stimulates flow by releasing endothelium-mediated vasorelaxant facto...

journal_title：Circulation research

authors： Recchia FA,Senzaki H,Saeki A,Byrne BJ,Kass DA

更新日期：1996-10-01 00:00:00

abstract：:Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract obstruction. In many of the families afflicted with either disease, causative mutations have been identified in various sarcomeric proteins. In this review, we focu...

journal_title：Circulation research

authors： Moore JR,Leinwand L,Warshaw DM

更新日期：2012-07-20 00:00:00

abstract：:Different myosin isoenzymes of pig and human atrium and ventricle and rat ventricle were characterized by two approaches: pyrophosphate polyacrylamide gel electrophoresis (PP-PAGE) and analysis of the myosin P light chains by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). We further investigated the rel...

journal_title：Circulation research

authors： Morano I,Arndt H,Gärtner C,Rüegg JC

更新日期：1988-03-01 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMC) is a primary cause of vascular disorders and is associated with major alterations in Ca2+ handling supported by loss of the sarco/endoplasmic reticulum calcium ATPase, SERCA2a. To determine the importance of SERCA2a in neointima formation, we have prevented loss of ...

journal_title：Circulation research

authors： Lipskaia L,del Monte F,Capiod T,Yacoubi S,Hadri L,Hours M,Hajjar RJ,Lompré AM

更新日期：2005-09-02 00:00:00

abstract：:Although human atherosclerosis is associated with aging, direct evidence of cellular senescence and the mechanism of senescence in vascular smooth muscle cells (VSMCs) in atherosclerotic plaques is lacking. We examined normal vessels and plaques by histochemistry, Southern blotting, and fluorescence in situ hybridizat...

journal_title：Circulation research

authors： Matthews C,Gorenne I,Scott S,Figg N,Kirkpatrick P,Ritchie A,Goddard M,Bennett M

更新日期：2006-07-21 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:The purpose of these studies was to evaluate cardiovascular structural and functional changes in a model of hypertension-induced myocardial hypertrophy in which vasodilator therapy decreased blood pressure to normal levels. Thus, we determined the separate contributions of hypertension and hypertrophy on myocardial an...

journal_title：Circulation research

authors： Anderson PG,Bishop SP,Digerness SB

更新日期：1989-06-01 00:00:00

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00

abstract：:Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to suppo...

journal_title：Circulation research

authors： Weber S,Bernhard D,Lukowski R,Weinmeister P,Wörner R,Wegener JW,Valtcheva N,Feil S,Schlossmann J,Hofmann F,Feil R

更新日期：2007-11-26 00:00:00

abstract：RATIONALE:Cell therapy is a promising option for the treatment of acute or chronic myocardial ischemia. The intracoronary infusion of cells imposes the potential risk of cell clotting, which may be prevented by the addition of anticoagulants. However, a comprehensive analysis of the effects of anticoagulants on the fun...

journal_title：Circulation research

authors： Seeger FH,Rasper T,Fischer A,Muhly-Reinholz M,Hergenreider E,Leistner DM,Sommer K,Manavski Y,Henschler R,Chavakis E,Assmus B,Zeiher AM,Dimmeler S

更新日期：2012-09-14 00:00:00

abstract：RATIONALE:Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity appears to be restricted mainly because of poor cell viability and low engraftment in the ischemic myocardium. Specific chemokines are upregulated ...

journal_title：Circulation research

authors： Huang J,Zhang Z,Guo J,Ni A,Deb A,Zhang L,Mirotsou M,Pratt RE,Dzau VJ

更新日期：2010-06-11 00:00:00

abstract：:Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined...

journal_title：Circulation research

authors： Oka M,Homma N,Taraseviciene-Stewart L,Morris KG,Kraskauskas D,Burns N,Voelkel NF,McMurtry IF

更新日期：2007-03-30 00:00:00

abstract：:Although the ultrasonic pulsatility index (PI) is used as a test of arterial inflow, the relationship between proximal arterial stenosis and PI has not been fully evaluated. In a series of experiments on dogs, over 200 measurements of pressure, flow (using an indwelling electromagnetic flowmeter), and PI were made dis...

journal_title：Circulation research

authors： Evans DH,Barrie WW,Asher MJ,Bentley S,Bell PR

更新日期：1980-04-01 00:00:00

abstract：:We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded concentrations of epinephrine, isoproterenol, and phenylephrine. Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 3...

journal_title：Circulation research

authors： Rosen MR,Hordof AJ,Ilvento JP,Danilo P Jr

更新日期：1977-04-01 00:00:00

abstract：:Atherosclerosis is considered to be an inflammatory disease. Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque rupture. Recent studies suggest that the antiinflammatory cyt...

journal_title：Circulation research

authors： Kamimura M,Viedt C,Dalpke A,Rosenfeld ME,Mackman N,Cohen DM,Blessing E,Preusch M,Weber CM,Kreuzer J,Katus HA,Bea F

更新日期：2005-08-19 00:00:00

abstract：:Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown. Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. Rat, m...

journal_title：Circulation research

authors： He Y,Yao G,Savoia C,Touyz RM

更新日期：2005-02-04 00:00:00

abstract：RATIONALE:B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a and the factors maintaining t...

journal_title：Circulation research

authors： Upadhye A,Srikakulapu P,Gonen A,Hendrikx S,Perry HM,Nguyen A,McSkimming C,Marshall MA,Garmey JC,Taylor AM,Bender TP,Tsimikas S,Holodick NE,Rothstein TL,Witztum JL,McNamara CA

更新日期：2019-10-25 00:00:00

abstract：:Increasing attention is currently devoted to the multiple roles that pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascular homeostasis, and pathology. Many recent excellent reviews thoroughly address these topics (see below); hence, we will not discuss them in detail h...

journal_title：Circulation research

authors： Cappellari O,Cossu G

更新日期：2013-07-19 00:00:00

abstract：:Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for increased ROS and to determine the contribution of superoxide anion (*O(2)(-)), H(2)O(2), and hydroxy radical (*OH) in failing myoca...

journal_title：Circulation research

authors： Ide T,Tsutsui H,Kinugawa S,Suematsu N,Hayashidani S,Ichikawa K,Utsumi H,Machida Y,Egashira K,Takeshita A

更新日期：2000-02-04 00:00:00

abstract：:The purpose of this study was to determine whether increased sympathetic nervous system activity with proportionally greater stimulation to the kidney could result in sustained hypertension. This was simulated by continuous intrarenal norepinephrine infusion. Effects of chronic infusion of norepinephrine (0.285 micron...

journal_title：Circulation research

authors： Katholi RE,Carey RM,Ayers CR,Vaughan ED Jr,Yancey MR,Morton CL

更新日期：1977-05-01 00:00:00

abstract：:We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin re...

journal_title：Circulation research

authors： Ayers CR,Katholi RE,Vaughan ED Jr,Carey RM,Kimbrough HM Jr,Yancey MR,Morton CL

更新日期：1977-03-01 00:00:00

abstract：:The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been define...

journal_title：Circulation research

authors： Mommersteeg MT,Hoogaars WM,Prall OW,de Gier-de Vries C,Wiese C,Clout DE,Papaioannou VE,Brown NA,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-02-16 00:00:00

abstract：:Previously we have shown that AIP1 (apoptosis signal-regulating kinase [ASK]1-interacting protein 1), a novel member of the Ras-GAP protein family, facilitates dephosphorylation of ASK1 at pSer967 and subsequently 14-3-3 release from ASK1, leading to enhanced ASK1-JNK signaling. However, the phosphatase(s) responsible...

journal_title：Circulation research

authors： Min W,Lin Y,Tang S,Yu L,Zhang H,Wan T,Luhn T,Fu H,Chen H

更新日期：2008-04-11 00:00:00

abstract：:The identification of nitric oxide ((*)NO) as an endogenously produced free radical mediator of endothelial-dependent relaxation and host defense has fundamentally changed concepts of cell signal transduction. Ligand-receptor oriented paradigms of cell signaling were originally centered on the concept of a high affini...

journal_title：Circulation research

authors： Rudolph V,Freeman BA

更新日期：2009-09-11 00:00:00

abstract：:We have identified immunologically the protein kinase C (PKC) isoforms present in rat mesenteric small arteries, defined their distribution between particulate and soluble fractions, and studied their involvement in phorbol ester-induced contraction. Our analysis revealed the presence of the CA(2+)-dependent PKCs (alp...

journal_title：Circulation research

authors： Ohanian V,Ohanian J,Shaw L,Scarth S,Parker PJ,Heagerty AM

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cells (LMCs) and their electrical coupling through Cxs, Cx-related lym...

journal_title：Circulation research

authors： Castorena-Gonzalez JA,Zawieja SD,Li M,Srinivasan RS,Simon AM,de Wit C,de la Torre R,Martinez-Lemus LA,Hennig GW,Davis MJ

更新日期：2018-09-28 00:00:00

abstract：:Fibroblast growth factor-1 (FGF-1), a prototype member of the heparin-binding growth factor family, is a potent mitogen for vascular endothelial cells and a variety of other cell types. FGF-1 can induce the expression of the platelet-derived growth factor-A chain (PDGF-A) gene in endothelial cells; however, the underl...

journal_title：Circulation research

authors： Delbridge GJ,Khachigian LM

更新日期：1997-08-01 00:00:00