AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.

abstract：:We determined whether cerebral arterioles in vitro adjust their diameters in response to changes in intraluminal flow rate and pressure. Intracerebral arterioles (38- to 55-microns diameter) were isolated from Sprague-Dawley rats and cannulated with a perfusion system that permitted separate control of intraluminal pr...

journal_title：Circulation research

authors： Ngai AC,Winn HR

更新日期：1995-10-01 00:00:00

abstract：:Cardiovascular dysfunction as a result of sepsis is the leading cause of death in the critically ill. Cardiomyocytes respond to infectious pathogens with a Toll-like receptor-initiated proinflammatory response in conjunction with a decrease in contractility, although the downstream events linking Toll-like receptor ac...

journal_title：Circulation research

authors： Boyd JH,Kan B,Roberts H,Wang Y,Walley KR

更新日期：2008-05-23 00:00:00

abstract：:We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect of TRPV1 on cytosol...

journal_title：Circulation research

authors： Zhang LL,Yan Liu D,Ma LQ,Luo ZD,Cao TB,Zhong J,Yan ZC,Wang LJ,Zhao ZG,Zhu SJ,Schrader M,Thilo F,Zhu ZM,Tepel M

更新日期：2007-04-13 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:We have previously studied the relation between long-chain fatty acid and pyruvate metabolism in reperfused myocardium and noted a rapid return of fatty acid oxidation to at least preischemic values accompanied by a marked decrease in pyruvate oxidation. The purpose of the present report is to further characterize car...

journal_title：Circulation research

authors： Renstrom B,Nellis SH,Liedtke AJ

更新日期：1989-10-01 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：RATIONALE:Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE:Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS:C57Bl6, Ace2 knockout (...

journal_title：Circulation research

authors： Thomas MC,Pickering RJ,Tsorotes D,Koitka A,Sheehy K,Bernardi S,Toffoli B,Nguyen-Huu TP,Head GA,Fu Y,Chin-Dusting J,Cooper ME,Tikellis C

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered. OBJECTIVE:The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ...

journal_title：Circulation research

authors： Wang Y,Wang X,Lau WB,Yuan Y,Booth D,Li JJ,Scalia R,Preston K,Gao E,Koch W,Ma XL

更新日期：2014-02-28 00:00:00

abstract：RATIONALE:Upregulation of endothelial vascular cell adhesion molecule (VCAM)-1 and the subsequent increase in monocyte recruitment constitute critical events in atherogenesis. We have recently shown that in human coronary artery endothelial cells (HCAECs) regulated expression of VCAM-1 depends, to a significant extent,...

journal_title：Circulation research

authors： Smedlund K,Tano JY,Vazquez G

更新日期：2010-05-14 00:00:00

abstract：:The remodeling of ventricular gap junctions, as defined by changes in size, distribution, or function, is a prominent feature of diseased myocardium. However, the regulation of assembly and maintenance of gap junctions remains poorly understood. To investigate N-cadherin function in the adult myocardium, we used a flo...

journal_title：Circulation research

authors： Li J,Patel VV,Kostetskii I,Xiong Y,Chu AF,Jacobson JT,Yu C,Morley GE,Molkentin JD,Radice GL

更新日期：2005-09-02 00:00:00

abstract：:Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals. After stimulation of the cardiac sympathetic nerves in anesthetized dogs, the action of the vagus nerve on heart...

journal_title：Circulation research

authors： Hall GT,Gardner TD,Potter EK

更新日期：1990-07-01 00:00:00

abstract：RATIONALE:Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE:To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS:We measure...

journal_title：Circulation research

authors： Augustine D,Ayers LV,Lima E,Newton L,Lewandowski AJ,Davis EF,Ferry B,Leeson P

更新日期：2014-01-03 00:00:00

abstract：:Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of ER stress proteins, many of which are protective and function to res...

journal_title：Circulation research

authors： Martindale JJ,Fernandez R,Thuerauf D,Whittaker R,Gude N,Sussman MA,Glembotski CC

更新日期：2006-05-12 00:00:00

abstract：:Gap junction pharmacology is a nascent field. Previous studies have identified molecules that enhance intercellular communication, and may offer potential for innovative antiarrhythmic therapy. However, their specific molecular target(s) and mechanism(s) of action remain unknown. Previously, we identified a 34-aa pept...

journal_title：Circulation research

authors： Verma V,Larsen BD,Coombs W,Lin X,Spagnol G,Sorgen PL,Taffet SM,Delmar M

更新日期：2009-07-17 00:00:00

abstract：RATIONALE:Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases. OBJECTIVE:To investigate whether cell senescence contributes to pulmonary vessel remodeling and pulmonary hypertension...

journal_title：Circulation research

authors： Noureddine H,Gary-Bobo G,Alifano M,Marcos E,Saker M,Vienney N,Amsellem V,Maitre B,Chaouat A,Chouaid C,Dubois-Rande JL,Damotte D,Adnot S

更新日期：2011-08-19 00:00:00

abstract：:The positive inotropic response to angiotensin I and II in cardiac tissue of most mammalian species, as well as the exact site in the heart for conversion of local and systemic angiotensin I into angiotensin II, remains to be elucidated. In isolated cat papillary muscles, angiotensin I and angiotensin II (0.1 nM to 1 ...

journal_title：Circulation research

authors： Meulemans AL,Andries LJ,Brutsaert DL

更新日期：1990-06-01 00:00:00

abstract：RATIONALE:Cardiac myosin-binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-282, and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest the nonequivalence of these sites and the potential importance of Ser-282 phosphorylation in modulating the protein's overall phosphorylation...

journal_title：Circulation research

authors： Sadayappan S,Gulick J,Osinska H,Barefield D,Cuello F,Avkiran M,Lasko VM,Lorenz JN,Maillet M,Martin JL,Brown JH,Bers DM,Molkentin JD,James J,Robbins J

更新日期：2011-07-08 00:00:00

abstract：RATIONALE:Calcium channel blockers (CCBs) are an important class of drugs in managing cardiovascular diseases. Patients usually rely on these medications for the remainder of their lives after diagnosis. Although the acute pharmacological actions of CCBs in the hearts are well-defined, little is known about the drug-sp...

journal_title：Circulation research

authors： Lam CK,Tian L,Belbachir N,Wnorowski A,Shrestha R,Ma N,Kitani T,Rhee JW,Wu JC

更新日期：2019-07-05 00:00:00

abstract：:To determine the relative roles of cardiac and sinoaortic baroreceptors in mediation of arginine vasopressin (AVP) release, hemorrhage was performed in five groups of conscious splenectomized dogs: 1) all nerves intact; 2) either chronic surgical or acute pharmacological (intrapericardial lidocaine) cardiac denervatio...

journal_title：Circulation research

authors： Shen YT,Cowley AW Jr,Vatner SF

更新日期：1991-05-01 00:00:00

abstract：:Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleot...

journal_title：Circulation research

authors： Omori K,Kotera J

更新日期：2007-02-16 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：:An affinity gel for the purification of renin was prepared by coupling pepstatin to aminohexylagarose gel. Partially purified human renin (Haas et al., Arch. Biochem. Biophys., 110, 534-543, 1965) was purified further by affinity chromatography on the pepstatin-aminohexyl-agarose gel, gel filtration on a Sephadex G-75...

journal_title：Circulation research

authors： Murakami K,Inagami T,Haas E

更新日期：1977-10-01 00:00:00

abstract：:Atrial tissue expresses both connexin 40 (Cx40) and 43 (Cx43) proteins. To assess the relative roles of Cx40 and Cx43 in atrial electrical propagation, we synthesized cultured strands of atrial myocytes derived from mice with genetic deficiency in Cx40 or Cx43 expression and measured propagation velocity (PV) by high-...

journal_title：Circulation research

authors： Beauchamp P,Yamada KA,Baertschi AJ,Green K,Kanter EM,Saffitz JE,Kléber AG

更新日期：2006-11-24 00:00:00

abstract：:The cardioprotection by ischemic preconditioning is lost in aged wild-type and in STAT3 (signal transducer and activator of transcription 3)-deficient mice. The aim of the present study was to analyze whether or not ischemic postconditioning (iPoco) was effective in aged mice hearts and whether iPoco was dependent on ...

journal_title：Circulation research

authors： Boengler K,Buechert A,Heinen Y,Roeskes C,Hilfiker-Kleiner D,Heusch G,Schulz R

更新日期：2008-01-04 00:00:00

abstract：:Stimulation of beta-adrenergic receptors (betaARs) causes apoptosis in adult rat ventricular myocytes (ARVMs). The role of reactive oxygen species (ROS) in mediating betaAR-stimulated apoptosis is not known. Stimulation of betaARs with norepinephrine (10 micromol/L) in the presence of prazosin (100 nmol/L) for 24 hour...

journal_title：Circulation research

authors： Remondino A,Kwon SH,Communal C,Pimentel DR,Sawyer DB,Singh K,Colucci WS

更新日期：2003-02-07 00:00:00

abstract：:Effects of blood flow on the production of prostacyclin (PGI2) were examined in the canine femoral artery perfused ex vivo. Each artery was perfused in situ with medium 199, under conditions of simulated blood flow. To simulate the normal and abnormal blood flow waveforms at the same mean flow rate, we developed a flo...

journal_title：Circulation research

authors： Onohara T,Okadome K,Yamamura S,Mii S,Sugimachi K

更新日期：1991-04-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：:Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during s...

journal_title：Circulation research

authors： Fallavollita JA,Malm BJ,Canty JM Jr

更新日期：2003-01-10 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：:Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggest...

journal_title：Circulation research

authors： Gkaliagkousi E,Ritter J,Ferro A

更新日期：2007-09-28 00:00:00