Production of sustained hypertension by chronic intrarenal norepinephrine infusion in conscious dogs.

abstract：:Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...

journal_title：Circulation research

authors： Cernadas MR,Sánchez de Miguel L,García-Durán M,González-Fernández F,Millás I,Montón M,Rodrigo J,Rico L,Fernández P,de Frutos T,Rodríguez-Feo JA,Guerra J,Caramelo C,Casado S,López-Farré

更新日期：1998-08-10 00:00:00

abstract：:Ca2+ influx through the L-type calcium channel (LTCC) induces Ca2+ release from the sarcoplasmic reticulum (SR) and maintains SR Ca2+ loading. Alterations in LTCC properties, their contribution to the blunted adrenergic responsiveness in failing hearts and their recovery after support with LV assist devices (LVAD) wer...

journal_title：Circulation research

authors： Chen X,Piacentino V 3rd,Furukawa S,Goldman B,Margulies KB,Houser SR

更新日期：2002-09-20 00:00:00

abstract：:Hypoxia is a potent coronary-vasodilating signal; its mechanisms are still controversial. We have assessed the possible role of nitric oxide (NO) in hypoxic coronary vasodilatation (HCVD) in isolated guinea pig hearts perfused at constant pressure. HCVD was elicited by a 1-minute 100% N2 exposure; coronary flow double...

journal_title：Circulation research

authors： Park KH,Rubin LE,Gross SS,Levi R

更新日期：1992-10-01 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：:During an investigation of the effect of ryanodine on contractions in cardiac muscle, it was found that long rest periods removed all or most of the drug's effect. Therefore, we studied the kinetics of block development and recovery from block produced by low concentrations of ryanodine (1-100 pM) on the postrest cont...

journal_title：Circulation research

authors： Malecot CO,Katzung BG

更新日期：1987-04-01 00:00:00

abstract：:The expression of angiotensin II type 2 (AT(2)) receptor is closely associated with cell growth, differentiation, and/or injury. We examined the effect of interferon (IFN)-gamma on AT(2) receptor expression in mouse fibroblast R3T3 cells and demonstrated that IFN-gamma treatment increased the expression of AT(2) recep...

journal_title：Circulation research

authors： Horiuchi M,Hayashida W,Akishita M,Yamada S,Lehtonen JY,Tamura K,Daviet L,Chen YE,Hamai M,Cui TX,Iwai M,Minokoshi Y

更新日期：2000-02-04 00:00:00

abstract：:The site of earliest extracellular electrical activation in the sinoatrial node (SAN) is known to shift in response to autonomic stimuli, but the mechanisms underlying this phenomenon and the determinants of the location of dominant pacemaker activity have not been elucidated. The present study was designed to charact...

journal_title：Circulation research

authors： Beau SL,Hand DE,Schuessler RB,Bromberg BI,Kwon B,Boineau JP,Saffitz JE

更新日期：1995-11-01 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:The influence of endothelin 1 on intracellular Ca2+ transients and isometric contractions was investigated in ferret papillary muscles loaded with the Ca(2+)-regulated bioluminescent indicator aequorin. In concentrations of 3 x 10(-9) to 1 x 10(-7) M, endothelin produced dose-dependent increases in the amplitudes of b...

journal_title：Circulation research

authors： Wang JX,Paik G,Morgan JP

更新日期：1991-09-01 00:00:00

abstract：:To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly...

journal_title：Circulation research

authors： Regnier M,Rivera AJ,Chen Y,Chase PB

更新日期：2000-06-23 00:00:00

abstract：:We recently established a new transgenic mouse model with brain-restricted overexpression of angiotensin II (Ang II) type 1a receptors (NSE-AT(1a)) to unmask the role of the brain renin-angiotensin system in hypertension. To test the hypothesis that these mice would exhibit an early exacerbation of renovascular hypert...

journal_title：Circulation research

authors： Lazartigues E,Lawrence AJ,Lamb FS,Davisson RL

更新日期：2004-09-03 00:00:00

abstract：:Oxidation converts low-density lipoprotein (LDL) into a cytotoxin in vitro. Oxidized LDL exists in vivo in atherosclerotic lesions and possibly in plasma. Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo. To test whether oxidized LDL could injure endothelial cells and alter ...

journal_title：Circulation research

authors： Rangaswamy S,Penn MS,Saidel GM,Chisolm GM

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. OBJEC...

journal_title：Circulation research

authors： Rassaf T,Totzeck M,Hendgen-Cotta UB,Shiva S,Heusch G,Kelm M

更新日期：2014-05-09 00:00:00

abstract：RATIONALE:Shear stress (SS) has an established role in atherosclerotic plaque localization, but how it exerts its protective effect is not fully understood. OBJECTIVE:To test the hypothesis that SS may downregulate angiotensin type 1 receptors (AT(1)Rs). Angiotensin II has been shown to be proinflammatory and to promo...

journal_title：Circulation research

authors： Ramkhelawon B,Vilar J,Rivas D,Mees B,de Crom R,Tedgui A,Lehoux S

更新日期：2009-10-23 00:00:00

abstract：:Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these...

journal_title：Circulation research

authors： Manabe I,Shindo T,Nagai R

更新日期：2002-12-13 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00

abstract：:The purpose of this study was to explore the changes in fetal blood volume that occur after fetal hemorrhage. Fifteen unanesthetized, chronically catheterized fetal sheep averaging 130 +/- 3 (SD) days gestation were studied 4 to 6 (average 5) days after catheter implantation. The fetuses were hemorrhaged by continuous...

journal_title：Circulation research

authors： Brace RA

更新日期：1983-06-01 00:00:00

abstract：:The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels...

journal_title：Circulation research

authors： Sukhova GK,Wang B,Libby P,Pan JH,Zhang Y,Grubb A,Fang K,Chapman HA,Shi GP

更新日期：2005-02-18 00:00:00

abstract：RATIONALE:Previous studies on the relationship between diabetes and arterial stiffness were mostly cross-sectional. A few longitudinal studies focused on one single direction. Whether the association between arterial stiffness and diabetes is bidirectional remains unclear to date. OBJECTIVE:To explore the temporal rel...

journal_title：Circulation research

authors： Zheng M,Zhang X,Chen S,Song Y,Zhao Q,Gao X,Wu S

更新日期：2020-12-04 00:00:00

abstract：:Pulsatile pulmonary hemodynamics were analyzed in a chronic awake canine high flow model. Standard mean flow and pulsatile flow hemodynamics were measured and alterations in the proximal pulmonary vascular physical properties were quantified by the characteristic impedance (Zo). Pulmonary vascular resistance (PVR), wh...

journal_title：Circulation research

authors： Hopkins RA,Hammon JW Jr,McHale PA,Smith PK,Anderson RW

更新日期：1979-08-01 00:00:00

abstract：:Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive hormones. The identity of EDHF remains unknown. Since arachidonic acid causes endothelium-dependent relaxations of coronary arteries through it...

journal_title：Circulation research

authors： Campbell WB,Gebremedhin D,Pratt PF,Harder DR

更新日期：1996-03-01 00:00:00

abstract：:By making use of immunoblotting and immunocytochemical analysis, we explored whether stimulation of adenosine A1 receptors would promote the activation of delta-protein kinase C (delta-PKC) immunolabeled with a polyclonal antibody. Immunoblot analysis of Triton X-100-soluble cell membrane and cytosolic fractions revea...

journal_title：Circulation research

authors： Henry P,Demolombe S,Pucéat M,Escande D

更新日期：1996-01-01 00:00:00

abstract：:Two characteristic features of the rapid component of the cardiac delayed rectifier current (IKr) are prominent inward rectification and an unexpected reduction in activating current with decreased [K+]o. Similar features are observed with heterologous expression of HERG, the gene thought to encode the channel carryin...

journal_title：Circulation research

authors： Yang T,Snyders DJ,Roden DM

更新日期：1997-06-01 00:00:00

abstract：:Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of...

journal_title：Circulation research

authors： Tseng H,Peterson TE,Berk BC

更新日期：1995-11-01 00:00:00

abstract：:The patch-clamp technique was used to examine the inhibition of delayed rectifier K+ channels by agents that release intracellular Ca2+. During voltage-clamp experiments on isolated myocytes with 4-aminopyridine (4-AP, 10 mmol/L) and niflumic acid (100 mumol/L) present to inhibit delayed rectifier K+ current (IK(dr)) ...

journal_title：Circulation research

authors： Gelband CH,Hume JR

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Mitochondria are key integrators of convergent intracellular signaling pathways. Two important second messengers modulated by mitochondria are calcium and reactive oxygen species. To date, coherent mechanisms describing mitochondrial integration of calcium and oxidative signaling in arterial smooth muscle are...

journal_title：Circulation research

authors： Chaplin NL,Nieves-Cintrón M,Fresquez AM,Navedo MF,Amberg GC

更新日期：2015-12-04 00:00:00

abstract：:Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable ...

journal_title：Circulation research

authors： Bentzon JF,Otsuka F,Virmani R,Falk E

更新日期：2014-06-06 00:00:00

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:Alterations in voltage-dependent Ca2+ channels in the arterial smooth muscle cells of spontaneously hypertensive rats (SHR) were investigated using the whole-cell voltage clamp and compared with Wistar-Kyoto (WKY) rats. Single cells were freshly isolated from resistance mesenteric arteries from 4- to 5-week-old (young...

journal_title：Circulation research

authors： Ohya Y,Abe I,Fujii K,Takata Y,Fujishima M

更新日期：1993-12-01 00:00:00

abstract：:Increasing evidence suggests that endogenous NO inhibits sympathetic outflow in anesthetized animals. However, in a recent study from this laboratory, we were unable to find any evidence of increased renal sympathetic nerve activity (RSNA) in response to blockade of NO synthesis in conscious rabbits. Because angiotens...

journal_title：Circulation research

authors： Liu JL,Murakami H,Zucker IH

更新日期：1998-03-09 00:00:00