Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo.

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic d...

journal_title：Circulation research

authors： Clark EB,Hu N

更新日期：1982-12-01 00:00:00

abstract：:We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 microgra...

journal_title：Circulation research

authors： Raffestin B,Levame M,Eddahibi S,Viossat I,Braquet P,Chabrier PE,Cantin M,Adnot S

更新日期：1992-01-01 00:00:00

abstract：:This study aimed at identifying the type and functional significance of potassium channels and voltage-dependent calcium channels (Ca(v)) in single rat JG cells using whole-cell patch clamp. Single JG cells displayed outward rectification at positive membrane potentials and limited net currents between -60 and -10 mV....

journal_title：Circulation research

authors： Friis UG,Jørgensen F,Andreasen D,Jensen BL,Skøtt O

更新日期：2003-08-08 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:Recent studies have shown that the primary heart tube continues to grow by addition of cells from the coelomic wall. This growth occurs concomitantly with embryonic folding and formation of the coelomic cavity, making early heart formation morphologically complex. A scarcity of data on localized growth parameters furt...

journal_title：Circulation research

authors： van den Berg G,Abu-Issa R,de Boer BA,Hutson MR,de Boer PA,Soufan AT,Ruijter JM,Kirby ML,van den Hoff MJ,Moorman AF

更新日期：2009-01-30 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：:In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure...

journal_title：Circulation research

authors： Brown DL,Guyenet PG

更新日期：1985-03-01 00:00:00

abstract：:Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these...

journal_title：Circulation research

authors： Manabe I,Shindo T,Nagai R

更新日期：2002-12-13 00:00:00

abstract：:Raising the hepatic venous pressure experimentally duplicates the type of hepatic congestion seen in many clinical situations including congestive heart failure. Venous pressure was controlled using a hepatic venous long circuit preparation and was raised by 6 cm blood (4.7 mm Hg) or 10 cm (7.8 mm Hg). Total splanchni...

journal_title：Circulation research

authors： Lautt WW

更新日期：1977-12-01 00:00:00

abstract：RATIONALE:Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However, enhancement of particular aspects of cAMP/protein kinase A signaling seems to be beneficial for the failing heart. cAMP is a pleiotropic second messenger with t...

journal_title：Circulation research

authors： Zoccarato A,Surdo NC,Aronsen JM,Fields LA,Mancuso L,Dodoni G,Stangherlin A,Livie C,Jiang H,Sin YY,Gesellchen F,Terrin A,Baillie GS,Nicklin SA,Graham D,Szabo-Fresnais N,Krall J,Vandeput F,Movsesian M,Furlan L,Corse

更新日期：2015-09-25 00:00:00

abstract：:Transforming growth factor (TGF)-beta(1) is a potent stimulator of intimal growth. We showed previously that TGF-beta(1) stimulates intimal growth through early upregulation of plasminogen activator inhibitor-1 (PAI-1) and, subsequently, PAI-1-dependent increases in cell migration and matrix accumulation. We also show...

journal_title：Circulation research

authors： Otsuka G,Stempien-Otero A,Frutkin AD,Dichek DA

更新日期：2007-05-11 00:00:00

abstract：:To elucidate the local effects of renin in the coronary circulation, we examined local angiotensin (Ang) I and II formation, as well as coronary vasoconstriction in response to renin administration, and compared the effects with exogenous infused Ang I. We perfused isolated hearts from rats overexpressing the human an...

journal_title：Circulation research

authors： Müller DN,Fischli W,Clozel JP,Hilgers KF,Bohlender J,Ménard J,Busjahn A,Ganten D,Luft FC

更新日期：1998-01-09 00:00:00

abstract：:Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized alpha4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endoth...

journal_title：Circulation research

authors： Goldfinger LE,Tzima E,Stockton R,Kiosses WB,Kinbara K,Tkachenko E,Gutierrez E,Groisman A,Nguyen P,Chien S,Ginsberg MH

更新日期：2008-07-18 00:00:00

abstract：RATIONALE:Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. Proprotein convertase subtilisin/kexin type 9 (PCSK9) selectively binds low-density lipoprotein; we hypothesized that it can also be associate...

journal_title：Circulation research

authors： Tavori H,Christian D,Minnier J,Plubell D,Shapiro MD,Yeang C,Giunzioni I,Croyal M,Duell PB,Lambert G,Tsimikas S,Fazio S

更新日期：2016-06-24 00:00:00

abstract：:Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

journal_title：Circulation research

authors： Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

更新日期：1992-12-01 00:00:00

abstract：:As early as the 4th embryonic day, the ventricle of the chick embryo responded to isoproterenol (Iso) with an increase in the force of contraction; at all ages studied, this positive inotropic effect was accompanied by an increased rate of tension development. There was a transient, 10-fold decrease in the sensitivity...

journal_title：Circulation research

authors： Higgins D,Pappano AJ

更新日期：1981-02-01 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：:Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. I...

journal_title：Circulation research

authors： Ryoo S,Gupta G,Benjo A,Lim HK,Camara A,Sikka G,Lim HK,Sohi J,Santhanam L,Soucy K,Tuday E,Baraban E,Ilies M,Gerstenblith G,Nyhan D,Shoukas A,Christianson DW,Alp NJ,Champion HC,Huso D,Berkowitz DE

更新日期：2008-04-25 00:00:00

abstract：:The effects of digoxin on monovalent cation active transport were determined in cardiac tissue obtained from dogs given inotropic, toxic, or lethal doses of digoxin. In hemodynamically monitored dogs, active uptake of the K+ analogue Rb+ was determined in vitro in a control myocardial biopsy, and then in serial biopsi...

journal_title：Circulation research

authors： Hougen TJ,Lloyd BL,Smith TW

更新日期：1979-01-01 00:00:00

abstract：:Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using st...

journal_title：Circulation research

authors： Miragoli M,Salvarani N,Rohr S

更新日期：2007-10-12 00:00:00

abstract：:The SCN5A gene encodes the alpha subunit of the human heart sodium channel (hH1), which plays a critical role in cardiac excitability. Mutations of SCN5A underlie Brugada syndrome, an inherited disorder that leads to ventricular fibrillation and sudden death. This study describes changes in cellular localization and f...

journal_title：Circulation research

authors： Baroudi G,Pouliot V,Denjoy I,Guicheney P,Shrier A,Chahine M

更新日期：2001-06-22 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:Ryanodine receptor (RyR) phosphorylation by protein kinase A (PKA) may be important in modulating resting sarcoplasmic reticulum (SR) Ca2+ release, especially in heart failure. However, clear cellular data on PKA-dependent modulation of cardiac RyRs is limited because of difficulty in distinguishing between PKA effect...

journal_title：Circulation research

authors： Li Y,Kranias EG,Mignery GA,Bers DM

更新日期：2002-02-22 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：:A distal transcriptional enhancer has been previously reported upstream of the mouse renin gene. A homologous sequence is also present upstream of the human renin gene, but the mouse and human renin enhancers differ markedly in their ability to activate transcription of a renin promoter. Although the 2 enhancers share...

journal_title：Circulation research

authors： Shi Q,Black TA,Gross KW,Sigmund CD

更新日期：1999-09-17 00:00:00

abstract：:During periodic stimulation of spontaneously beating chick heart cell aggregates, there is often an evolution of coupling patterns between the stimulator and the aggregate action potential. For example, at rapid stimulation frequencies, a rhythm that is initially 1:1 (stimulus frequency:aggregate frequency) can evolve...

journal_title：Circulation research

authors： Zeng WZ,Glass L,Shrier A

更新日期：1991-10-01 00:00:00

abstract：:Blood pressure (BP) control in patients with hypertension is variable worldwide, and in general, it results largely unsatisfactory. Factors responsible for this phenomenon include insufficient national cardiovascular healthcare policies for prevention, poor patient compliance with prescribed treatment schedules, and t...

journal_title：Circulation research

authors： Mancia G,Rea F,Corrao G,Grassi G

更新日期：2019-03-29 00:00:00

abstract：:This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive ...

journal_title：Circulation research

authors： Hansson GK,Libby P,Schönbeck U,Yan ZQ

更新日期：2002-08-23 00:00:00

abstract：:Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction. In this report, we link Notch signaling to platelet-derived growth factor (PDGF) signaling, a ...

journal_title：Circulation research

authors： Jin S,Hansson EM,Tikka S,Lanner F,Sahlgren C,Farnebo F,Baumann M,Kalimo H,Lendahl U

更新日期：2008-06-20 00:00:00