Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.

abstract：:In recent year, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and ...

journal_title：Circulation research

authors： Uchida S,Dimmeler S

更新日期：2015-02-13 00:00:00

abstract：:Controversy exists whether positive end-expiratory pressure (PEEP) ventilation lowers cardiac output by reducing left ventricular preload, or by a combination of mechanisms. Sixteen open-chest dogs were instrumented for measurement of left and right ventricular pressure, aortic flow, and left ventricular dimensions. W...

journal_title：Circulation research

authors： Darsee JR,Mikolich JR,Walter PF,Schlant RC

更新日期：1981-10-01 00:00:00

abstract：:Given the essential role played by gap junctions in the coordination of cardiac muscle contraction, it is plausible that down-regulation of gap junctional conduction is in part responsible for the contractile dysfunction observed in hypertrophied and failing hearts. In the present study, we analyzed the expression and...

journal_title：Circulation research

authors： Toyofuku T,Yabuki M,Otsu K,Kuzuya T,Tada M,Hori M

更新日期：1999-10-15 00:00:00

abstract：:In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to dete...

journal_title：Circulation research

authors： Lindner V,Fingerle J,Reidy MA

更新日期：1993-11-01 00:00:00

abstract：:Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest a potential causal role of C-peptide in atherogenesis by promoting monocyte and T-lymphocyte recruitment into the vessel wall. The present study examine...

journal_title：Circulation research

authors： Walcher D,Babiak C,Poletek P,Rosenkranz S,Bach H,Betz S,Durst R,Grüb M,Hombach V,Strong J,Marx N

更新日期：2006-11-24 00:00:00

abstract：RATIONALE:Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translat...

journal_title：Circulation research

authors： Haubner BJ,Schneider J,Schweigmann U,Schuetz T,Dichtl W,Velik-Salchner C,Stein JI,Penninger JM

更新日期：2016-01-22 00:00:00

abstract：:During ischemia and reperfusion, with an increase in intracellular Na+ and a depolarized membrane potential, Ca2+ may enter the myocyte in exchange for intracellular Na+ via reverse-mode Na+-Ca2+ exchange (NCX). To test the role of Ca2+ entry via NCX during ischemia and reperfusion, we studied mice with cardiac-specif...

journal_title：Circulation research

authors： Imahashi K,Pott C,Goldhaber JI,Steenbergen C,Philipson KD,Murphy E

更新日期：2005-10-28 00:00:00

abstract：:Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogeno...

journal_title：Circulation research

authors： Ping P,Takano H,Zhang J,Tang XL,Qiu Y,Li RC,Banerjee S,Dawn B,Balafonova Z,Bolli R

更新日期：1999-03-19 00:00:00

abstract：:By use of gene targeting and/or transgenesis, it is now possible to make defined changes in genes whose functions underlie mammalian cardiovascular function. Because of technical and economic considerations, these experiments are largely confined to the mouse. Genetic modification of the loci responsible for aspects o...

journal_title：Circulation research

authors： James JF,Hewett TE,Robbins J

更新日期：1998-03-09 00:00:00

abstract：:Elastance-resistance [E(t)-R] representations of the left ventricle (LV) were evaluated for their ability to reproduce instantaneous pressure [P(t)] and outflow [Q(t)]. Experiments were performed in open-chest rats. P(t) and Q(t) were measured during steady-state ejecting beats and during a beat in which the aorta was...

journal_title：Circulation research

authors： Campbell KB,Kirkpatrick RD,Knowlen GG,Ringo JA

更新日期：1990-01-01 00:00:00

abstract：:Many cell types undergo apoptosis under conditions of ischemia. Little is known, however, about the molecular pathways that mediate this response. A cellular and biochemical approach to elucidate such signaling pathways was undertaken in primary cultures of cardiac myocytes, a cell type that is especially sensitive to...

journal_title：Circulation research

authors： Bialik S,Cryns VL,Drincic A,Miyata S,Wollowick AL,Srinivasan A,Kitsis RN

更新日期：1999-09-03 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) plays a critical role in the contractile performance of cardiac and slow-twitch skeletal muscle by restoring cytosolic calcium to low resting levels during the contractile cycle. We have previously shown that SERCA2 expression in the heart is altered by a number of pat...

journal_title：Circulation research

authors： Fisher SA,Buttrick PM,Sukovich D,Periasamy M

更新日期：1993-10-01 00:00:00

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：:We have previously shown that a cryoactivatable inactive form of renin, which we have tentatively termed prorenin, occurs in human plasma. Plasma prorenin is measured by subtracting the endogenous plasma renin activity (PRA) from the total renin activity measured after cryoactivation. Cryoactivation is accomplished by...

journal_title：Circulation research

authors： Sealey JE,Moon C,Laragh JH,Atlas SA

更新日期：1977-05-01 00:00:00

abstract：:F2-Isoprostanes are novel bioactive prostaglandin F2-like compounds produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. F2-Isoprostanes are initially formed in situ on phospholipids and subsequently released. Quantification of the F2-isoprostanes has been found to represent a valuable and...

journal_title：Circulation research

authors： Moore KP,Darley-Usmar V,Morrow J,Roberts LJ 2nd

更新日期：1995-08-01 00:00:00

abstract：:We investigated expression of the 5'-spliced isoform of smooth muscle myosin heavy chain (SM-MHC-B) in smooth muscle cells of cardiac vessels of the left ventricle of normotensive (Wistar-Kyoto) and spontaneously hypertensive rats of the stroke-prone strain by immunofluorescence microscopy. In parallel, liver and blad...

journal_title：Circulation research

authors： Wetzel U,Lutsch G,Haase H,Ganten U,Morano I

更新日期：1998-07-27 00:00:00

abstract：:Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using st...

journal_title：Circulation research

authors： Miragoli M,Salvarani N,Rohr S

更新日期：2007-10-12 00:00:00

abstract：:To investigate the relation of pressure and vascular wall thickening in hypertension, we coarcted the abdominal aorta upstream to the renal arteries in 14 rats. Sham-coarcted (n = 16) and two-kidney, one-clip (Goldblatt) hypertensive rats (n = 13) served as controls. Tail, femoral, and carotid arterial pressures rose ...

journal_title：Circulation research

authors： Liu JL,Bishop SP,Overbeck HW

更新日期：1988-05-01 00:00:00

abstract：RATIONALE:The sarcolemma of cardiomyocytes contains many proteins that are essential for electromechanical function in general, and excitation-contraction coupling in particular. The distribution of these proteins is nonuniform between the bulk sarcolemmal surface and membrane invaginations known as transverse tubules ...

journal_title：Circulation research

authors： Rog-Zielinska EA,Scardigli M,Peyronnet R,Zgierski-Johnston CM,Greiner J,Madl J,O'Toole ET,Morphew M,Hoenger A,Sacconi L,Kohl P

更新日期：2021-01-22 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：:Angiotensin II (Ang II) plays an important role in post-myocardial infarction (MI) remodeling. Most Ang II effects related to remodeling involve activation of the type 1 receptor (AT(1)). Although the AT(1) receptor is upregulated on cardiac fibroblasts post-MI, little is known about the mechanisms involved in the pro...

journal_title：Circulation research

authors： Gurantz D,Cowling RT,Villarreal FJ,Greenberg BH

更新日期：1999-08-06 00:00:00

abstract：RATIONALE:Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor. However, there is lack of experimental evidence. OBJECTIVE:In this study, we investigated inflammation-associated stroke using a mouse model that ...

journal_title：Circulation research

authors： Hollander MC,Latour LL,Yang D,Ishii H,Xiao Z,Min Y,Ray-Choudhury A,Munasinghe J,Merchant AS,Lin PC,Hallenbeck J,Boehm M,Yang L

更新日期：2017-12-08 00:00:00

abstract：:Recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. To identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myo...

journal_title：Circulation research

authors： Neubauer S,Hamman BL,Perry SB,Bittl JA,Ingwall JS

更新日期：1988-07-01 00:00:00

abstract：:Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...

journal_title：Circulation research

authors： Barbuti A,Gravante B,Riolfo M,Milanesi R,Terragni B,DiFrancesco D

更新日期：2004-05-28 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：:Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

journal_title：Circulation research

authors： Joly GA,Schini VB,Vanhoutte PM

更新日期：1992-08-01 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00

abstract：RATIONALE:The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who receive a proteasome inhibitor-containing regime show cardiotoxicity. Mo...

journal_title：Circulation research

authors： Pan B,Li J,Parajuli N,Tian Z,Wu P,Lewno MT,Zou J,Wang W,Bedford L,Mayer RJ,Fang J,Liu J,Cui T,Su H,Wang X

更新日期：2020-07-31 00:00:00