Effects of acute, passive hepatic congestion on blood flow and oxygen uptake in the intact liver of the cat.

abstract：:Pyridine nucleotides are abundant soluble coenzymes and they undergo reversible oxidation and reduction in several biological electron-transfer reactions. They are comprised of two mononucleotides, adenosine monophosphate and nicotinamide mononucleotide, and are present as oxidized and reduced nicotinamide adenine din...

journal_title：Circulation research

authors： Nakamura M,Bhatnagar A,Sadoshima J

更新日期：2012-08-17 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity of endothelial cells. Although the mitogenic activity of VEGF is endothelial cell specific, recent reports indicate VEGF is able to stimulate chemotaxis and tissue factor...

journal_title：Circulation research

authors： Wang H,Keiser JA

更新日期：1998-10-19 00:00:00

abstract：:Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggest...

journal_title：Circulation research

authors： Gkaliagkousi E,Ritter J,Ferro A

更新日期：2007-09-28 00:00:00

abstract：:Endocardial endothelium and endothelium of coronary vessels produce NO. Histochemical methods have suggested that coronary arterial endothelial cells contain more endothelial constitutive NO synthase (ecNOS) than does coronary venous endothelium. We have further investigated the distribution of ecNOS in cardiac endoth...

journal_title：Circulation research

authors： Andries LJ,Brutsaert DL,Sys SU

更新日期：1998-02-09 00:00:00

abstract：RATIONALE:Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs). OBJECTIVE:To determine whether hyperglycemia in vitro and diabetes in vivo promote vascular BMP activity and c...

journal_title：Circulation research

authors： Boström KI,Jumabay M,Matveyenko A,Nicholas SB,Yao Y

更新日期：2011-02-18 00:00:00

abstract：RATIONALE:Necrosis is one of the main forms of cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types of necrosis are regulated and programmed dependent on the activation of receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-as...

journal_title：Circulation research

authors： Wang JX,Zhang XJ,Li Q,Wang K,Wang Y,Jiao JQ,Feng C,Teng S,Zhou LY,Gong Y,Zhou ZX,Liu J,Wang JL,Li PF

更新日期：2015-07-31 00:00:00

abstract：:Large conductance Ca(2+)-activated K(+) channels (BK(Ca)) play a critical role in blood pressure regulation by tuning the vascular smooth muscle tone, and hyposensitivity of BK(Ca) to Ca(2+) sparks resulting from its altered beta1 subunit stoichiometry underlies vasoconstriction in animal models of hypertension. Here ...

journal_title：Circulation research

authors： Zhao G,Zhao Y,Pan B,Liu J,Huang X,Zhang X,Cao C,Hou N,Wu C,Zhao KS,Cheng H

更新日期：2007-08-31 00:00:00

abstract：RATIONALE:Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications controlling its activation. OBJECTIVE:To determine whether posttran...

journal_title：Circulation research

authors： Streeter J,Schickling BM,Jiang S,Stanic B,Thiel WH,Gakhar L,Houtman JC,Miller FJ Jr

更新日期：2014-11-07 00:00:00

abstract：:Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in mouse heart stimulates the bigenomic mitochondrial biogenesis pr...

journal_title：Circulation research

authors： Piantadosi CA,Carraway MS,Babiker A,Suliman HB

更新日期：2008-11-21 00:00:00

abstract：:The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden o...

journal_title：Circulation research

authors： Chan NC,Eikelboom JW,Weitz JI

更新日期：2016-04-29 00:00:00

abstract：:In 36 normolipemic pigs randomized to a 4-week feeding with regular pig chow (n = 18, control group) or chow supplemented with cod liver oil (1 ml/kg per day) (n = 18, treated group), treatment with cod liver oil produced a significant decrease in serum cholesterol, low density lipoprotein cholesterol, and triglycerid...

journal_title：Circulation research

authors： Lam JY,Badimon JJ,Ellefson RD,Fuster V,Chesebro JH

更新日期：1992-10-01 00:00:00

abstract：:Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of...

journal_title：Circulation research

authors： Tseng H,Peterson TE,Berk BC

更新日期：1995-11-01 00:00:00

abstract：:Cardiac alpha-adrenergic receptors mediate cellular responses to norepinephrine through an undefined series of molecular events. We examined the possibility that phosphoinositide hydrolysis was stimulated through alpha-adrenergic receptors in cardiomyocytes purified from adult rat ventricle. Phosphoinositide stores we...

journal_title：Circulation research

authors： Brown JH,Buxton IL,Brunton LL

更新日期：1985-10-01 00:00:00

abstract：:A central role for leukocytes in neointimal hyperplasia after arterial injury is suspected. However, the relative importance of neutrophils and monocytes in balloon or stent-induced injury are not well understood, and mechanistic targeting of leukocyte recruitment or function is crude. We determined the temporal and s...

journal_title：Circulation research

authors： Horvath C,Welt FG,Nedelman M,Rao P,Rogers C

更新日期：2002-03-08 00:00:00

abstract：RATIONALE:The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholester...

journal_title：Circulation research

authors： Nelson JK,Sorrentino V,Avagliano Trezza R,Heride C,Urbe S,Distel B,Zelcer N

更新日期：2016-02-05 00:00:00

abstract：:Cold-induced vasoconstriction in cutaneous blood vessels is mediated in part by increased activity of vascular smooth muscle alpha2-adrenoceptors (VSM alpha2-ARs). In mouse cutaneous arteries, alpha2C-ARs are normally silent at 37 degrees C but mediate cold-induced augmentation of alpha2-AR responsiveness. In transfec...

journal_title：Circulation research

authors： Bailey SR,Eid AH,Mitra S,Flavahan S,Flavahan NA

更新日期：2004-05-28 00:00:00

abstract：:Effects of blood flow on the production of prostacyclin (PGI2) were examined in the canine femoral artery perfused ex vivo. Each artery was perfused in situ with medium 199, under conditions of simulated blood flow. To simulate the normal and abnormal blood flow waveforms at the same mean flow rate, we developed a flo...

journal_title：Circulation research

authors： Onohara T,Okadome K,Yamamura S,Mii S,Sugimachi K

更新日期：1991-04-01 00:00:00

abstract：:Calcium channel blockers (CCBs), which are used clinically for treatment of angina and hypertension, are known to inhibit calcium influx into arterial smooth muscle cells and thereby decrease smooth muscle cell contraction. In addition, they prevent cholesteryl ester (CE) accumulation, the hallmark of human atheroscle...

journal_title：Circulation research

authors： Etingin OR,Hajjar DP

更新日期：1990-01-01 00:00:00

abstract：:A new protocol has been developed for selective removal of the endothelium from the arteries of the perfused rat hind-limb preparation. The hind limb was perfused with oxygenated Krebs-Ringer bicarbonate solution with a combination of high flow and timed air bubbles (2 minutes at high flow followed by 5 minutes of air...

journal_title：Circulation research

authors： Ralevic V,Kristek F,Hudlická O,Burnstock G

更新日期：1989-06-01 00:00:00

abstract：RATIONALE:Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression. OBJECTIVE:To determine whether the lipid-free apoA-I-mediated and (A-I)rHDL-mediated ...

journal_title：Circulation research

authors： Wu BJ,Chen K,Shrestha S,Ong KL,Barter PJ,Rye KA

更新日期：2013-01-18 00:00:00

abstract：:Selective troponin I (TnI) modification has been demonstrated to be in part responsible for the contractile dysfunction observed with myocardial ischemia/reperfusion injury. We have isolated and characterized modified TnI products in isolated rat hearts after 0, 15, or 60 minutes of ischemia followed by 45 minutes of ...

journal_title：Circulation research

authors： McDonough JL,Arrell DK,Van Eyk JE

更新日期：1999-01-08 00:00:00

abstract：:The purpose of this study was to examine by freeze-fracture the ultrastructure of intercellular junctions between mouse pulmonary endothelial and epithelial cells, and to relate this fine structure to that deduced from previous physiological and ultrastructural studies using tracer techniques. Junctions between capill...

journal_title：Circulation research

authors： Schneeberger EE,Karnovsky MJ

更新日期：1976-05-01 00:00:00

abstract：:Phospholamban is a key regulatory protein that defines diastolic function. Proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) can depress contractility and intracellular Ca2+ currents and transients. An alteration in phospholamban expression is a possible pathway by wh...

journal_title：Circulation research

authors： McTiernan CF,Lemster BH,Frye C,Brooks S,Combes A,Feldman AM

更新日期：1997-10-01 00:00:00

abstract：:The rate of renin secretion from renal juxtaglomerular (JG) cells is the major determinant of the activity of the renin-angiotensin system. However, the mechanisms involved in the excretion and turnover of secretory granules in the JG cells remain obscure. Therefore, in the present study, the whole-cell patch-clamp te...

journal_title：Circulation research

authors： Friis UG,Jensen BL,Aas JK,Skøtt O

更新日期：1999-04-30 00:00:00

abstract：:Voltage-gated K(+) channels (Kv) play a critical role in regulating arterial tone by modulating the membrane potential of vascular smooth muscle cells. Our previous work demonstrated that the dominant 4-aminopyridine (4-AP)-sensitive, delayed rectifier Kv current of rabbit portal vein (RPV) myocytes demonstrates simil...

journal_title：Circulation research

authors： Thorneloe KS,Chen TT,Kerr PM,Grier EF,Horowitz B,Cole WC,Walsh MP

更新日期：2001-11-23 00:00:00

abstract：:The adenosine analogue phenylisopropyladenosine decreased the basal and isoproterenol-stimulated contractile state of isolated rat left atria. The ED50 levels for both responses were similar, suggesting that direct and antiadrenergic effects may be mediated by the same receptor. Phenylisopropyladenosine decreased the ...

journal_title：Circulation research

authors： Linden J,Hollen CE,Patel A

更新日期：1985-05-01 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:Previous work has shown that neutrophils isolated from whole blood adhere to cardiac-myocytes via CD18 (beta 2 integrin) to cause injury to the heart cells. In vitro, we have found that upon endothelial transmigration, neutrophils can also express alpha 4 beta 1; however, whether this contributes to neutrophil adhesio...

journal_title：Circulation research

authors： Reinhardt PH,Ward CA,Giles WR,Kubes P

更新日期：1997-08-01 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:By use of gene targeting and/or transgenesis, it is now possible to make defined changes in genes whose functions underlie mammalian cardiovascular function. Because of technical and economic considerations, these experiments are largely confined to the mouse. Genetic modification of the loci responsible for aspects o...

journal_title：Circulation research

authors： James JF,Hewett TE,Robbins J

更新日期：1998-03-09 00:00:00