The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

abstract：:Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity of endothelial cells. Although the mitogenic activity of VEGF is endothelial cell specific, recent reports indicate VEGF is able to stimulate chemotaxis and tissue factor...

journal_title：Circulation research

authors： Wang H,Keiser JA

更新日期：1998-10-19 00:00:00

abstract：:Transcriptional thyroid hormone responsiveness of the cardiac alpha-myosin heavy chain (alpha-MHC) gene has been demonstrated in transfections into fetal and neonatal cardiomyocytes and in transgenic mice. However, the correspondence between the regulation of MHC expression in dissociated cells with that in the intact...

journal_title：Circulation research

authors： Buttrick PM,Kaplan ML,Kitsis RN,Leinwand LA

更新日期：1993-06-01 00:00:00

abstract：:Increasing attention is currently devoted to the multiple roles that pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascular homeostasis, and pathology. Many recent excellent reviews thoroughly address these topics (see below); hence, we will not discuss them in detail h...

journal_title：Circulation research

authors： Cappellari O,Cossu G

更新日期：2013-07-19 00:00:00

abstract：RATIONALE:Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE:We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS:We identified CD40 as a...

journal_title：Circulation research

authors： Yang J,Fang P,Yu D,Zhang L,Zhang D,Jiang X,Yang WY,Bottiglieri T,Kunapuli SP,Yu J,Choi ET,Ji Y,Yang X,Wang H

更新日期：2016-11-11 00:00:00

abstract：:The vasoactive mechanisms of the serine protease alpha-thrombin were examined in isolated coronary arteries from dogs. In resting coronary arteries with endothelium, alpha-thrombin caused concentration-dependent contractions that were characterized by an initial transient relaxation followed by slowly developing susta...

journal_title：Circulation research

authors： Tesfamariam B

更新日期：1994-05-01 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00

abstract：:Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriogr...

journal_title：Circulation research

authors： Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1992-03-01 00:00:00

abstract：RATIONALE:Innate and adaptive immune responses alter numerous homeostatic processes that are controlled by nuclear hormone receptors. NR4A1 is a nuclear receptor that is induced in vascular pathologies, where it mediates protection. OBJECTIVE:The underlying mechanisms that regulate the activity of NR4A1 during vascula...

journal_title：Circulation research

authors： Papac-Milicevic N,Breuss JM,Zaujec J,Ryban L,Plyushch T,Wagner GA,Fenzl S,Dremsek P,Cabaravdic M,Steiner M,Glass CK,Binder CJ,Uhrin P,Binder BR

更新日期：2012-04-13 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs). OBJECTIVE:To determine whether a PPARγ agonist reduces angiotensin II (Ang II)-induced ...

journal_title：Circulation research

authors： Subramanian V,Golledge J,Ijaz T,Bruemmer D,Daugherty A

更新日期：2010-10-15 00:00:00

abstract：RATIONALE:We studied a possibility that shRNAs can lead to transcriptional gene activation at the promoter level via epigenetic mechanism. OBJECTIVE:The purpose of this study was to test the effects on vascular endothelial growth factor (VEGF-A) expression by promoter targeted small hairpin RNAs (shRNAs) in vitro and ...

journal_title：Circulation research

authors： Turunen MP,Lehtola T,Heinonen SE,Assefa GS,Korpisalo P,Girnary R,Glass CK,Väisänen S,Ylä-Herttuala S

更新日期：2009-09-11 00:00:00

abstract：:Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, duration of antibiotic exposure may be a risk factor of premature ...

journal_title：Circulation research

authors： Heianza Y,Ma W,Li X,Cao Y,Chan AT,Rimm EB,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2020-01-31 00:00:00

abstract：RATIONALE:Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important ...

journal_title：Circulation research

authors： Glukhov AV,Fedorov VV,Lou Q,Ravikumar VK,Kalish PW,Schuessler RB,Moazami N,Efimov IR

更新日期：2010-03-19 00:00:00

abstract：RATIONALE:Closure of the ductus arteriosus (DA) is essential for the transition from fetal to neonatal patterns of circulation. Initial PO2-dependent vasoconstriction causes functional DA closure within minutes. Within days a fibrogenic, proliferative mechanism causes anatomic closure. Though modulated by endothelial-d...

journal_title：Circulation research

authors： Hong Z,Kutty S,Toth PT,Marsboom G,Hammel JM,Chamberlain C,Ryan JJ,Zhang HJ,Sharp WW,Morrow E,Trivedi K,Weir EK,Archer SL

更新日期：2013-03-01 00:00:00

abstract：:The bioactivity of nitric oxide (.NO) depends, in part, on its interaction with superoxide. Usually, superoxide dismutase (SOD) preserves .NO bioactivity by limiting the availability of superoxide. Ascorbic acid also effectively scavenges superoxide, but the extent to which this interaction is necessary for intact .NO...

journal_title：Circulation research

authors： Jackson TS,Xu A,Vita JA,Keaney JF Jr

更新日期：1998-11-02 00:00:00

abstract：RATIONALE:Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. OBJECTIVE:The goal of this study was to assess whether genome editing using a clus...

journal_title：Circulation research

authors： Ding Q,Strong A,Patel KM,Ng SL,Gosis BS,Regan SN,Cowan CA,Rader DJ,Musunuru K

更新日期：2014-08-15 00:00:00

abstract：:Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed ...

journal_title：Circulation research

authors： Solaro RJ,Shiner JS

更新日期：1976-07-01 00:00:00

abstract：:Mammalian cardiomyocytes irreversibly lose their capacity to proliferate soon after birth, yet the underlying mechanisms have been unclear. Cyclin D1 and its partner, cyclin-dependent kinase 4 (CDK4), are important for promoting the G1-to-S phase progression via phosphorylation of the retinoblastoma (Rb) protein. Mito...

journal_title：Circulation research

authors： Tamamori-Adachi M,Ito H,Sumrejkanchanakij P,Adachi S,Hiroe M,Shimizu M,Kawauchi J,Sunamori M,Marumo F,Kitajima S,Ikeda MA

更新日期：2003-01-10 00:00:00

abstract：:The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypert...

journal_title：Circulation research

authors： Shirakabe A,Ikeda Y,Sciarretta S,Zablocki DK,Sadoshima J

更新日期：2016-05-13 00:00:00

abstract：:Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

journal_title：Circulation research

authors： van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

更新日期：2020-06-19 00:00:00

abstract：:The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) plays a critical role in the contractile performance of cardiac and slow-twitch skeletal muscle by restoring cytosolic calcium to low resting levels during the contractile cycle. We have previously shown that SERCA2 expression in the heart is altered by a number of pat...

journal_title：Circulation research

authors： Fisher SA,Buttrick PM,Sukovich D,Periasamy M

更新日期：1993-10-01 00:00:00

abstract：RATIONALE:Thousands of mutations across >50 genes have been implicated in inherited cardiomyopathies. However, options for sequencing this rapidly evolving gene set are limited because many sequencing services and off-the-shelf kits suffer from slow turnaround, inefficient capture of genomic DNA, and high cost. Further...

journal_title：Circulation research

authors： Wilson KD,Shen P,Fung E,Karakikes I,Zhang A,InanlooRahatloo K,Odegaard J,Sallam K,Davis RW,Lui GK,Ashley EA,Scharfe C,Wu JC

更新日期：2015-09-11 00:00:00

abstract：:We describe a straightforward gene-targeting technique to achieve uniform, stable, and genetically invariant expression of a transgene in the vascular endothelium of mice. To demonstrate the feasibility of this approach, the reporter gene bacterial beta-galactosidase was inserted via homologous recombination into the ...

journal_title：Circulation research

authors： Weiler-Guettler H,Aird WC,Husain M,Rayburn H,Rosenberg RD

更新日期：1996-02-01 00:00:00

abstract：:Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine ...

journal_title：Circulation research

authors： Corson MA,James NL,Latta SE,Nerem RM,Berk BC,Harrison DG

更新日期：1996-11-01 00:00:00

abstract：:Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial calcification. Inflammatory macrophages colocalize with BCP deposits in developing atherosclerotic lesions and in vitro can promote calcification through the release of TNF alpha. Here we have investigated whether BCP crystals can e...

journal_title：Circulation research

authors： Nadra I,Mason JC,Philippidis P,Florey O,Smythe CD,McCarthy GM,Landis RC,Haskard DO

更新日期：2005-06-24 00:00:00

abstract：:Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to suppo...

journal_title：Circulation research

authors： Weber S,Bernhard D,Lukowski R,Weinmeister P,Wörner R,Wegener JW,Valtcheva N,Feil S,Schlossmann J,Hofmann F,Feil R

更新日期：2007-11-26 00:00:00

abstract：:We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart...

journal_title：Circulation research

authors： Karim F,Hainsworth R,Sofola OA,Wood LM

更新日期：1980-01-01 00:00:00

abstract：:Fibroblast growth factor-1 (FGF-1), a prototype member of the heparin-binding growth factor family, is a potent mitogen for vascular endothelial cells and a variety of other cell types. FGF-1 can induce the expression of the platelet-derived growth factor-A chain (PDGF-A) gene in endothelial cells; however, the underl...

journal_title：Circulation research

authors： Delbridge GJ,Khachigian LM

更新日期：1997-08-01 00:00:00

abstract：:The effects of mechanical factors on nuclear factor (NF)-kappaB activation and its potential functional roles have been very little explored in the intact vessel. Thus, we chose to study the regulation of NF-kappaB by intraluminal pressure using an organ culture model of mouse carotid arteries maintained at 80 or 150 ...

journal_title：Circulation research

authors： Lemarié CA,Esposito B,Tedgui A,Lehoux S

更新日期：2003-08-08 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：:The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and high incidence of sudden death, despite causing little or no cardiac hypertrophy in patients. Transgenic mice expressing mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy...

journal_title：Circulation research

authors： Knollmann BC,Kirchhof P,Sirenko SG,Degen H,Greene AE,Schober T,Mackow JC,Fabritz L,Potter JD,Morad M

更新日期：2003-03-07 00:00:00