Abstract:
:Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed in 0.04 vs. 1.0 mM Mg2+, whereas a similar decrease in free Mg2+ slightly enhanced skeletal myofibrillar ATPase. Lowering free Mg2+ from 1.0 to 0.04 mM caused similar increases in cardiac and skeletal myofibrillar bound calcium, which were largely attributable to increased calcium binding to myofibrillar myosin. Raising free Mg2+ from 1.0 to 10.0 mM caused only a slight decrease of skeletal myofibrillar bound calcium, and this change was attributable to myofibrillar myosin. The same increase in free Mg2+ caused cardiac myofibrils to bind increased amounts of calcium and this change was not attributable to myofibrillar myosin. By subtracting calcium bound to myofibrillar myosin, we were able to estimate calcium binding by myofibrillar troponin. The transition between basal and maximal ATPase in 1.0 and 10 mM Mg2+ was found to be assocciated with binding of an additional 2 mol/mol of either skeletal or cardiac myofibrillar troponin.
journal_name
Circ Resjournal_title
Circulation researchauthors
Solaro RJ,Shiner JSdoi
10.1161/01.res.39.1.8subject
Has Abstractpub_date
1976-07-01 00:00:00pages
8-14issue
1eissn
0009-7330issn
1524-4571journal_volume
39pub_type
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.1.9
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doi:10.1161/CIRCRESAHA.115.304164
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-03-31 00:00:00
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doi:10.1161/01.res.51.3.290
更新日期:1982-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.178384
更新日期:2008-08-29 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.62.2.358
更新日期:1988-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.62.2.315
更新日期:1988-02-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.114.301374
更新日期:2014-01-17 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.4.992
更新日期:1992-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2009-07-17 00:00:00
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更新日期:1994-03-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2013-08-30 00:00:00
abstract::We recently established a new transgenic mouse model with brain-restricted overexpression of angiotensin II (Ang II) type 1a receptors (NSE-AT(1a)) to unmask the role of the brain renin-angiotensin system in hypertension. To test the hypothesis that these mice would exhibit an early exacerbation of renovascular hypert...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000140892.86313.c2
更新日期:2004-09-03 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-07-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1981-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-04-30 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2007-02-16 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.6.1652
更新日期:1991-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00