Abstract:
:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodium excretion was due primarily to a significant increase in the percent of the filtered sodium excreted. Deoxycorticosterone acetate (DOCA) and antiduretic hormone (ADH) had no substantial effects on these responses. The finding of a vasopressin-resistant hyposthenuria is consistent with the natriuresis of immersion being due, at least in part, to a decrease in sodium reabsorption proximal to the diluting segment, possibly the proximal tubule. Bilateral cervical vagotomy had no substantial influence on the renal responses to immersion, demonstrating that cardiopulmonary receptors whose axons traverse the vagus nerves are not necessary for the homeostatic adjustments to central hypervolemia in the primate. Since the renal and cardiovascular responses of the primate to immersion are essentially the same as those seen in man, it is probable that vagal pathways also are not necessary in man. However, it is possible that sympathetic afferents are involved in the natriuresis observed in the primate during immersion.
journal_name
Circ Resjournal_title
Circulation researchauthors
Gilmore JP,Zucker IHdoi
10.1161/01.res.42.2.263subject
Has Abstractpub_date
1978-02-01 00:00:00pages
263-7issue
2eissn
0009-7330issn
1524-4571journal_volume
42pub_type
杂志文章abstract::Accumulation of plasminogen activator inhibitor type 1 (PAI-1) in the arterial wall may accelerate atherogenesis by inhibiting fibrinolysis, diminishing proteolysis of extracellular matrix proteins, or modifying migration of vascular smooth muscle cells. Increased intramural expression of the PAI-1 gene is induced by ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.73.4.671
更新日期:1993-10-01 00:00:00
abstract::We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.46.1.77
更新日期:1980-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.120.317372
更新日期:2021-01-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.res.87.2.88
更新日期:2000-07-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.75.3.591
更新日期:1994-09-01 00:00:00
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journal_title:Circulation research
pub_type: 评审
doi:10.1161/CIRCRESAHA.120.316203
更新日期:2020-05-22 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000038887.17976.33
更新日期:2002-10-18 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.84.11.1237
更新日期:1999-06-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000071355.82009.43
更新日期:2003-05-16 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.48.4.498
更新日期:1981-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000229267.77982.0d
更新日期:2006-06-23 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.116.309115
更新日期:2017-01-20 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.117.306712
更新日期:2015-07-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.84.1.113
更新日期:1999-01-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000064174.69165.66
更新日期:2003-03-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.55.3.404
更新日期:1984-09-01 00:00:00
abstract::To investigate the effect of lactate, pyruvate, and glucose on the endogenous levels of lipids in the normoxic, ischemic, and reperfused myocardium, isolated working rat hearts were exposed to various grades of ischemic insult (15, 30, or 45 minutes). Glucose was present as the basal substrate in the perfusion medium,...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.72.1.176
更新日期:1993-01-01 00:00:00
abstract::Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.81.5.672
更新日期:1997-11-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.84.3.266
更新日期:1999-02-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.66.5.1204
更新日期:1990-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.9.e33
更新日期:1999-10-29 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.188292
更新日期:2009-04-10 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.262519
更新日期:2012-05-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.53.2.274
更新日期:1983-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.74.6.1141
更新日期:1994-06-01 00:00:00
abstract::The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inwa...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.39.1.106
更新日期:1976-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.36.6.761
更新日期:1975-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.254573
更新日期:2011-10-28 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000262653.84850.8b
更新日期:2007-04-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.248880
更新日期:2011-09-02 00:00:00