Limitations of the double sucrose gap voltage clamp technique in tension-voltage determinations on frog atrial muscle.

abstract：RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...

journal_title：Circulation research

authors： Stiermaier T,Jensen JO,Rommel KP,de Waha-Thiele S,Fuernau G,Desch S,Thiele H,Eitel I

更新日期：2019-05-10 00:00:00

abstract：RATIONALE:Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis and repair. Myofibroblasts, a specialized cell type that switches from a fibroblast-like state to a contractil...

journal_title：Circulation research

authors： Small EM,Thatcher JE,Sutherland LB,Kinoshita H,Gerard RD,Richardson JA,Dimaio JM,Sadek H,Kuwahara K,Olson EN

更新日期：2010-07-23 00:00:00

abstract：:Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed...

journal_title：Circulation research

authors： Zhang Q,Timofeyev V,Lu L,Li N,Singapuri A,Long MK,Bond CT,Adelman JP,Chiamvimonvat N

更新日期：2008-02-29 00:00:00

abstract：RATIONALE:The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting fibrosis and ...

journal_title：Circulation research

authors： Russo I,Cavalera M,Huang S,Su Y,Hanna A,Chen B,Shinde AV,Conway SJ,Graff J,Frangogiannis NG

更新日期：2019-04-12 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and, in particular, MMP-9 are important for smooth muscle cell (SMC) migration into the intima. In this study, we sought to determine whether MMP-9 is critical for SMC migration and for the formation of a neointima by using mice in which the gene was deleted (MMP-9(-/-) mice). A denudi...

journal_title：Circulation research

authors： Cho A,Reidy MA

更新日期：2002-11-01 00:00:00

abstract：:Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy. Myocytes isolated from the midmyocardium of 13 dogs with heart failure induced by 3 to 4 wee...

journal_title：Circulation research

authors： Kääb S,Nuss HB,Chiamvimonvat N,O'Rourke B,Pak PH,Kass DA,Marban E,Tomaselli GF

更新日期：1996-02-01 00:00:00

abstract：:The dynamic interaction of simultaneously changing heart period and single vagal stimuli on atrioventricular conduction (AV interval) was quantified by subtracting the vagally induced responses of the paced heart preparation from those of the unpaced heart preparation. This difference was significantly greater (P less...

journal_title：Circulation research

authors： Martin P

更新日期：1977-01-01 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:Glycerophosphate and carnitine as competing acyl acceptors and the oxidation of different long chain acylcarnitines in isolated mitochondria have been investigated. In the presence of low concentrations of palmitate, glycerophosphate is the preferred acyl acceptor in isolated liver mitochondria, indicating that the gl...

journal_title：Circulation research

authors： Borrebaek B,Christiansen R,Christophersen BO,Bremer J

更新日期：1976-05-01 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) is a newly identified endotheli...

journal_title：Circulation research

authors： Li L,Roumeliotis N,Sawamura T,Renier G

更新日期：2004-10-29 00:00:00

abstract：:Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric st...

journal_title：Circulation research

authors： Zaccolo M,Movsesian MA

更新日期：2007-06-08 00:00:00

abstract：:Although clinical trials of cell-based approaches to cardiovascular disease have yielded some promising results, no cell-based therapy has achieved regulatory approval for a cardiovascular indication. To broadly assess the challenges to regulatory approval and identify strategies to facilitate this goal, the Cardiac S...

journal_title：Circulation research

authors： Fanaroff AC,Morrow V,Krucoff MW,Seltzer JH,Perin EC,Taylor DA,Miller LW,Zeiher AM,Fernández-Avilés F,Losordo DW,Henry TD,Povsic TJ

更新日期：2018-08-03 00:00:00

abstract：:Fcγ receptors (FcγRs) classically modulate intracellular signaling on binding of the Fc region of IgG in immune response cells. How FcγR and their ligands affect cardiovascular health and disease has been interrogated recently in both preclinical and clinical studies. The stimulation of activating FcγR in endothelial ...

journal_title：Circulation research

authors： Tanigaki K,Sundgren N,Khera A,Vongpatanasin W,Mineo C,Shaul PW

更新日期：2015-01-16 00:00:00

abstract：RATIONALE:Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS). OBJECTIVE:We aimed to investigate the number of CPCs in ACS compared with those with stable coronary artery disease (CAD), relationship between bone marrow...

journal_title：Circulation research

authors： Samman Tahhan A,Hammadah M,Raad M,Almuwaqqat Z,Alkhoder A,Sandesara PB,Mohamed-Kelli H,Hayek SS,Kim JH,O'Neal WT,Topel ML,Grant AJ,Sabbak N,Heinl RE,Gafeer MM,Obideen M,Kaseer B,Abdelhadi N,Ko YA,Liu C,Hesaroieh I

更新日期：2018-05-25 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kappaB to apoptosis, it is still controversial. Especially, the r...

journal_title：Circulation research

authors： Matsushita H,Morishita R,Nata T,Aoki M,Nakagami H,Taniyama Y,Yamamoto K,Higaki J,Yasufumi K,Ogihara T

更新日期：2000-05-12 00:00:00

abstract：:Vessel stabilization and the inhibition of side effects such as tissue edema are essential in angiogenic gene therapy. Thus, combination gene transfers stimulating both endothelial cell and pericyte proliferation have become of interest. However, there is currently little data to support combination gene transfer in l...

journal_title：Circulation research

authors： Korpisalo P,Karvinen H,Rissanen TT,Kilpijoki J,Marjomäki V,Baluk P,McDonald DM,Cao Y,Eriksson U,Alitalo K,Ylä-Herttuala S

更新日期：2008-11-07 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：:Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reduction...

journal_title：Circulation research

authors： Hasegawa K,Wakino S,Tatematsu S,Yoshioka K,Homma K,Sugano N,Kimoto M,Hayashi K,Itoh H

更新日期：2007-07-20 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:In intact porcine aorta, endothelium-derived nitric oxide released on thrombin stimulation inhibits the concomitant production of endothelin. Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous an...

journal_title：Circulation research

authors： Boulanger CM,Lüscher TF

更新日期：1991-06-01 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：RATIONALE:We previously discovered several phosphorylations to the beta subunit of the mitochondrial F(1)F(o) ATP synthase complex in isolated rabbit myocytes on adenosine treatment, an agent that induces cardioprotection. The role of these phosphorylations is unknown. OBJECTIVE:The present study focuses on the functi...

journal_title：Circulation research

authors： Kane LA,Youngman MJ,Jensen RE,Van Eyk JE

更新日期：2010-02-19 00:00:00

abstract：:The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation an...

journal_title：Circulation research

authors： Horsthuis T,Buermans HP,Brons JF,Verkerk AO,Bakker ML,Wakker V,Clout DE,Moorman AF,'t Hoen PA,Christoffels VM

更新日期：2009-07-02 00:00:00

abstract：:The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels...

journal_title：Circulation research

authors： Sukhova GK,Wang B,Libby P,Pan JH,Zhang Y,Grubb A,Fang K,Chapman HA,Shi GP

更新日期：2005-02-18 00:00:00

abstract：:The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied se...

journal_title：Circulation research

authors： Spaet TH,Stemerman MB,Veith FJ,Lejnieks I

更新日期：1975-01-01 00:00:00

abstract：:Whereas numerous studies have investigated the role of prostacyclin and thromboxane A2 in the maintenance of coronary blood flow, most of these have focused on normal vessels. In the present investigation, we examined the prostaglandin- and thromboxane-synthesizing capacity of isolated coronary artery segments obtaine...

journal_title：Circulation research

authors： Schmitz JM,Apprill PG,Buja LM,Willerson JT,Campbell WB

更新日期：1985-08-01 00:00:00

abstract：:AR-L 115BS, a benzimidazole derivative, is a positive inotropic agent that has been shown to increase active tension development and unloaded shortening velocity of chemically skinned heart muscle preparations at submaximal activating levels of free Ca++. We measured the effect of AR-L on relations between free Ca++, ...

journal_title：Circulation research

authors： Solaro RJ,Rüegg JC

更新日期：1982-09-01 00:00:00

abstract：RATIONALE:Mechanisms underlying diastolic dysfunction need to be better understood. OBJECTIVE:To study the role of titin in diastolic dysfunction using a mouse model of experimental heart failure induced by transverse aortic constriction. METHODS AND RESULTS:Eight weeks after transverse aortic constriction surgery, m...

journal_title：Circulation research

authors： Hudson B,Hidalgo C,Saripalli C,Granzier H

更新日期：2011-09-30 00:00:00

abstract：:The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlu...

journal_title：Circulation research

authors： Richeson JF,Akiyama T,Schenk E

更新日期：1978-12-01 00:00:00