Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury.

abstract：:Previous studies have shown that cardiac endothelial cells release substances that influence myocardial contraction. Since PO2 is an important stimulus that modulates endothelial function, we investigated the effects of acute moderate hypoxia and reoxygenation on the release of cardioactive factors by endothelial cell...

journal_title：Circulation research

authors： Shah AM,Mebazaa A,Yang ZK,Cuda G,Lankford EB,Pepper CB,Sollott SJ,Sellers JR,Robotham JL,Lakatta EG

更新日期：1997-05-01 00:00:00

abstract：:The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium i...

journal_title：Circulation research

authors： Schiebinger RJ

更新日期：1989-09-01 00:00:00

abstract：:It has been shown previously that serotonin stimulates the production of prostacyclin by bovine aortic smooth muscle cells in culture, via 5-HT2 receptors (Coughlin SR, Moskowitz MA, Antoniades HN, Levine L. Proc Natl Acad Sci USA 1981;78:7134-7138). These cells express a synthetic phenotype, whereas the majority of t...

journal_title：Circulation research

authors： Demolle D,Van Coevorden A,Boeynaems JM

更新日期：1989-04-01 00:00:00

abstract：:Transmembrane potentials, extracellular potassium activity, and intracellular sodium activity were determined during acute global ischemia in Langendorff perfused guinea pig ventricles by microelectrode techniques. Resting membrane potential decreased with a sigmoidal time course from -82 mV to -49.5 +/- 2.7 mV (SD, n...

journal_title：Circulation research

authors： Kléber AG

更新日期：1983-04-01 00:00:00

abstract：:Endothelial cells isolated from bovine aortas without prior treatment with enzymes were cultured in RPMI 1640 medium containing 17% fetal calf serum and antibiotics. The endothelial cells at confluency (7 days) were similar to endothelium in situ or to freshly isolated endothelial cells from blood vessels as seen by l...

journal_title：Circulation research

authors： Shepro D,Batbouta JC,Robblee LS,Carson MP,Belamarich FA

更新日期：1975-06-01 00:00:00

abstract：:Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of...

journal_title：Circulation research

authors： Tseng H,Peterson TE,Berk BC

更新日期：1995-11-01 00:00:00

abstract：:Alpha1-adrenoceptor (alpha1-AR) stimulation increases sarcolemmal Na+-H+ exchanger (NHE) activity. The present study was designed to determine the role(s) of alpha1-AR subtype(s) in mediating this response. As an index of NHE activity, acid efflux rates (JHs) were determined in single rat ventricular myocytes loaded w...

journal_title：Circulation research

authors： Yokoyama H,Yasutake M,Avkiran M

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases. OBJECTIVE:To investigate whether cell senescence contributes to pulmonary vessel remodeling and pulmonary hypertension...

journal_title：Circulation research

authors： Noureddine H,Gary-Bobo G,Alifano M,Marcos E,Saker M,Vienney N,Amsellem V,Maitre B,Chaouat A,Chouaid C,Dubois-Rande JL,Damotte D,Adnot S

更新日期：2011-08-19 00:00:00

abstract：:To investigate the contributions of humoral and hemodynamic factors to cardiac adaptations associated with chronic exercise, female Fischer 344 rats were subjected to chronic swimming, infrarenal cardiac transplantation, or both. Swimming resulted in hypertrophy (11-12%) of the in situ hearts in both the unoperated an...

journal_title：Circulation research

authors： Advani SV,Geenen D,Malhotra A,Factor SM,Scheuer J

更新日期：1990-09-01 00:00:00

abstract：RATIONALE:Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. OBJECTIVE:To investigate the mechanism by which FGF signaling regulates cardiac progenitor cell differentiation. ME...

journal_title：Circulation research

authors： Zhang J,Liu J,Huang Y,Chang JY,Liu L,McKeehan WL,Martin JF,Wang F

更新日期：2012-02-17 00:00:00

abstract：RATIONALE:Wnt signaling regulates key aspects of diabetic vascular disease. OBJECTIVE:We generated SM22-Cre;LRP6(fl/fl);LDLR(-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6) in the vascular smooth muscle lineage of male low-density lipoprotein receptor-nu...

journal_title：Circulation research

authors： Cheng SL,Ramachandran B,Behrmann A,Shao JS,Mead M,Smith C,Krchma K,Bello Arredondo Y,Kovacs A,Kapoor K,Brill LM,Perera R,Williams BO,Towler DA

更新日期：2015-07-03 00:00:00

abstract：:The vasoactive mechanisms of the serine protease alpha-thrombin were examined in isolated coronary arteries from dogs. In resting coronary arteries with endothelium, alpha-thrombin caused concentration-dependent contractions that were characterized by an initial transient relaxation followed by slowly developing susta...

journal_title：Circulation research

authors： Tesfamariam B

更新日期：1994-05-01 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF possesses a binding site for ECM components that maintain i...

journal_title：Circulation research

authors： Ehrbar M,Djonov VG,Schnell C,Tschanz SA,Martiny-Baron G,Schenk U,Wood J,Burri PH,Hubbell JA,Zisch AH

更新日期：2004-04-30 00:00:00

abstract：:Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogeno...

journal_title：Circulation research

authors： Ping P,Takano H,Zhang J,Tang XL,Qiu Y,Li RC,Banerjee S,Dawn B,Balafonova Z,Bolli R

更新日期：1999-03-19 00:00:00

abstract：:Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila. The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow...

journal_title：Circulation research

authors： Shukla S,Fisher SA

更新日期：2008-08-29 00:00:00

abstract：:Vascular disease often involves vessel hypertrophy with underlying cellular hypertrophy or hyperplasia. Experimental diabetes stimulates hypertrophy of the rat mesenteric vasculature, and we investigated the hypothesis that this hypertrophy is associated with activation of Na(+)-H(+) exchange (NHE) activity. We measur...

journal_title：Circulation research

authors： Jandeleit-Dahm K,Hannan KM,Farrelly CA,Allen TJ,Rumble JR,Gilbert RE,Cooper ME,Little PJ

更新日期：2000-12-08 00:00:00

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：:We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system whic...

journal_title：Circulation research

authors： Sanchez-Chapula J,Tsuda Y,Josephson IR

更新日期：1983-05-01 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

journal_title：Circulation research

authors： Marx N,Duez H,Fruchart JC,Staels B

更新日期：2004-05-14 00:00:00

abstract：:To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular ce...

journal_title：Circulation research

authors： Lee RT,Smith TW,Marsh JD

更新日期：1987-05-01 00:00:00

abstract：:The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Fi...

journal_title：Circulation research

authors： Mommersteeg MT,Brown NA,Prall OW,de Gier-de Vries C,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-10-26 00:00:00

abstract：:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal tr...

journal_title：Circulation research

authors： Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee A

更新日期：1995-01-01 00:00:00

abstract：:Acute increases in arterial pulsatile load imposed on the left ventricle can increase coronary flow without commensurate changes in myocardial oxygen consumption. One explanation is that augmenting pulsatile perfusion at the same mean pressure itself stimulates flow by releasing endothelium-mediated vasorelaxant facto...

journal_title：Circulation research

authors： Recchia FA,Senzaki H,Saeki A,Byrne BJ,Kass DA

更新日期：1996-10-01 00:00:00

abstract：:Arteries from deoxycorticosterone acetate (DOCA)-salt and N(omega)-nitro-L-arginine (L-NNA) hypertensive but not normotensive rats develop spontaneous tone. LY294002 and wortmannin, phosphoinositide 3-kinase (PI3-kinase) inhibitors, eliminate spontaneous tone. We hypothesized that PI3-kinase protein and/or activity wa...

journal_title：Circulation research

authors： Northcott CA,Poy MN,Najjar SM,Watts SW

更新日期：2002-08-23 00:00:00

abstract：RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation. OBJECTIVE:We hypothesized that YAP activation after myocardial infarction (MI) would preserve cardiac function and improve survival. METHODS AND RESULTS:We use...

journal_title：Circulation research

authors： Lin Z,von Gise A,Zhou P,Gu F,Ma Q,Jiang J,Yau AL,Buck JN,Gouin KA,van Gorp PR,Zhou B,Chen J,Seidman JG,Wang DZ,Pu WT

更新日期：2014-07-18 00:00:00

abstract：:Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

journal_title：Circulation research

authors： Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

更新日期：1984-03-01 00:00:00

abstract：:The patch-clamp technique was used to examine the inhibition of delayed rectifier K+ channels by agents that release intracellular Ca2+. During voltage-clamp experiments on isolated myocytes with 4-aminopyridine (4-AP, 10 mmol/L) and niflumic acid (100 mumol/L) present to inhibit delayed rectifier K+ current (IK(dr)) ...

journal_title：Circulation research

authors： Gelband CH,Hume JR

更新日期：1995-07-01 00:00:00

abstract：:Ventricular/vascular coupling dynamics and regional hemodynamics of five hypertensive baboons with concentric left ventricular (LV) hypertrophy (mean arterial pressure +/- SD, 148 +/- 16 mm Hg; LV mass/body weight ratio 3.42 +/- 0.8) were compared with five normotensive controls (mean arterial pressure 89 +/- 3 mm Hg;...

journal_title：Circulation research

authors： Latham RD,Rubal BJ,Sipkema P,Westerhof N,Virmani R,Robinowitz M,Walsh RA

更新日期：1988-10-01 00:00:00