Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.

abstract：:In vitro and in vivo evidence indicates that hemodynamic wall shear stress evokes a diversity of biological responses in vascular endothelial cells, ranging from cell shape changes to alterations in low density lipoprotein receptor expression. The signal transduction mechanisms by which the level of fluid mechanical s...

journal_title：Circulation research

authors： Prasad AR,Logan SA,Nerem RM,Schwartz CJ,Sprague EA

更新日期：1993-04-01 00:00:00

abstract：RATIONALE:Human heregulins, neuregulin-1 type I polypeptides that activate proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions. Macrophage foam cell formation, characterized by cholesterol ester accumula...

journal_title：Circulation research

authors： Xu G,Watanabe T,Iso Y,Koba S,Sakai T,Nagashima M,Arita S,Hongo S,Ota H,Kobayashi Y,Miyazaki A,Hirano T

更新日期：2009-08-28 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：:Activation of protein kinase C has been implicated in the regulation of a variety of cellular reactions. Although we, and others, have found protein kinase C and its substrate proteins to be present in both membrane and cytosolic fractions in the heart, the physiologic role of this kinase in the regulation of cardiac ...

journal_title：Circulation research

authors： Yuan SH,Sunahara FA,Sen AK

更新日期：1987-09-01 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：:This study aimed at identifying the type and functional significance of potassium channels and voltage-dependent calcium channels (Ca(v)) in single rat JG cells using whole-cell patch clamp. Single JG cells displayed outward rectification at positive membrane potentials and limited net currents between -60 and -10 mV....

journal_title：Circulation research

authors： Friis UG,Jørgensen F,Andreasen D,Jensen BL,Skøtt O

更新日期：2003-08-08 00:00:00

abstract：:Raising the hepatic venous pressure experimentally duplicates the type of hepatic congestion seen in many clinical situations including congestive heart failure. Venous pressure was controlled using a hepatic venous long circuit preparation and was raised by 6 cm blood (4.7 mm Hg) or 10 cm (7.8 mm Hg). Total splanchni...

journal_title：Circulation research

authors： Lautt WW

更新日期：1977-12-01 00:00:00

abstract：:Stem cells can differentiate into a variety of cells to replace dead cells or to repair damaged tissues. Recent evidence indicates that stem cells are involved in the pathogenesis of transplant arteriosclerosis, an alloimmune initiated vascular stenosis that often results in transplant organ failure. Although the path...

journal_title：Circulation research

authors： Xu Q

更新日期：2008-05-09 00:00:00

abstract：:The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

journal_title：Circulation research

authors： Luo CH,Rudy Y

更新日期：1994-06-01 00:00:00

abstract：:We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system whic...

journal_title：Circulation research

authors： Sanchez-Chapula J,Tsuda Y,Josephson IR

更新日期：1983-05-01 00:00:00

abstract：:Recent advances in our understanding of the contribution of thrombin generation to arterial thrombosis and the role of platelets in venous thrombosis have prompted new treatment paradigms. Nonetheless, bleeding remains the major side effect of such treatments spurring the quest for new antithrombotic regimens with bet...

journal_title：Circulation research

authors： Chan NC,Weitz JI

更新日期：2019-02-01 00:00:00

abstract：:To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

journal_title：Circulation research

authors： Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

更新日期：2002-04-05 00:00:00

abstract：:To investigate the effect of lactate, pyruvate, and glucose on the endogenous levels of lipids in the normoxic, ischemic, and reperfused myocardium, isolated working rat hearts were exposed to various grades of ischemic insult (15, 30, or 45 minutes). Glucose was present as the basal substrate in the perfusion medium,...

journal_title：Circulation research

authors： de Groot MJ,Coumans WA,Willemsen PH,van der Vusse GJ

更新日期：1993-01-01 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased PCO2 from 23 to 74 mm Hg in anesthetized dogs and observed a marked antinatr...

journal_title：Circulation research

authors： Anderson RJ,Henrich WL,Gross PA,Dillingham MA

更新日期：1982-02-01 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：RATIONALE:Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. OBJECTIVE:Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-AR (adrenergic receptor) agonist. METHO...

journal_title：Circulation research

authors： Myagmar BE,Ismaili T,Swigart PM,Raghunathan A,Baker AJ,Sahdeo S,Blevitt JM,Milla ME,Simpson PC

更新日期：2019-09-13 00:00:00

abstract：:Controversy exists whether positive end-expiratory pressure (PEEP) ventilation lowers cardiac output by reducing left ventricular preload, or by a combination of mechanisms. Sixteen open-chest dogs were instrumented for measurement of left and right ventricular pressure, aortic flow, and left ventricular dimensions. W...

journal_title：Circulation research

authors： Darsee JR,Mikolich JR,Walter PF,Schlant RC

更新日期：1981-10-01 00:00:00

abstract：:Phospholamban is a key regulatory protein that defines diastolic function. Proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) can depress contractility and intracellular Ca2+ currents and transients. An alteration in phospholamban expression is a possible pathway by wh...

journal_title：Circulation research

authors： McTiernan CF,Lemster BH,Frye C,Brooks S,Combes A,Feldman AM

更新日期：1997-10-01 00:00:00

abstract：:The prevalence of obesity has increased worldwide over the past few decades. In 2013, the prevalence of obesity exceeded the 50% of the adult population in some countries from Oceania, North Africa, and Middle East. Lower but still alarmingly high prevalence was observed in North America (≈30%) and in Western Europe (...

journal_title：Circulation research

authors： Ortega FB,Lavie CJ,Blair SN

更新日期：2016-05-27 00:00:00

abstract：:We quantitated phasic epimyocardial microcirculatory coronary blood flow velocity patterns in the beating left ventricle. Using a newly developed floating objective and high-speed cinematography, red cell velocities in small arterioles, capillaries, and small venules and microvascular diameters in the superficial laye...

journal_title：Circulation research

authors： Ashikawa K,Kanatsuka H,Suzuki T,Takishima T

更新日期：1986-12-01 00:00:00

abstract：:Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila. The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow...

journal_title：Circulation research

authors： Shukla S,Fisher SA

更新日期：2008-08-29 00:00:00

abstract：RATIONALE:The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signal...

journal_title：Circulation research

authors： Singh N,Trivedi CM,Lu M,Mullican SE,Lazar MA,Epstein JA

更新日期：2011-11-11 00:00:00

abstract：:Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had seve...

journal_title：Circulation research

authors： Overend CL,Eisner DA,O'Neill SC

更新日期：2001-02-02 00:00:00

abstract：:The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO. In the present study, we investigated the contribution of...

journal_title：Circulation research

authors： Motterlini R,Gonzales A,Foresti R,Clark JE,Green CJ,Winslow RM

更新日期：1998-09-07 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:In addition to its role in reverse cholesterol transport, high-density lipoprotein (HDL) cholesterol has direct action on numerous cell types that influence cardiovascular and metabolic health. Cellular responses to HDL entail its capacity to invoke cholesterol efflux that causes signal initiation via scavenger recept...

journal_title：Circulation research

authors： Mineo C,Shaul PW

更新日期：2012-09-28 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00