Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.

abstract：RATIONALE:The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting fibrosis and ...

journal_title：Circulation research

authors： Russo I,Cavalera M,Huang S,Su Y,Hanna A,Chen B,Shinde AV,Conway SJ,Graff J,Frangogiannis NG

更新日期：2019-04-12 00:00:00

abstract：:Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogeno...

journal_title：Circulation research

authors： Ping P,Takano H,Zhang J,Tang XL,Qiu Y,Li RC,Banerjee S,Dawn B,Balafonova Z,Bolli R

更新日期：1999-03-19 00:00:00

abstract：:Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

journal_title：Circulation research

authors： Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

更新日期：2009-04-10 00:00:00

abstract：:Intussusceptive angiogenesis is a novel mode of blood vessel formation and remodeling, which occurs by internal division of the preexisting capillary plexus without sprouting. In this study, the process is demonstrated in developing chicken eye vasculature and in the chorioallantoic membrane by methylmethacrylate (Mer...

journal_title：Circulation research

authors： Djonov V,Schmid M,Tschanz SA,Burri PH

更新日期：2000-02-18 00:00:00

abstract：:Our objective was to test the hypotheses that 1) myoplasmic [Ca2+] is the primary determinant of crossbridge phosphorylation and that 2) phosphorylation is the primary determinant of crossbridge interactions with the thin filament in swine carotid arterial smooth muscle. We tested these hypotheses by evaluating the re...

journal_title：Circulation research

authors： Rembold CM,Murphy RA

更新日期：1988-09-01 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：RATIONALE:Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. OBJECTIVE:Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-AR (adrenergic receptor) agonist. METHO...

journal_title：Circulation research

authors： Myagmar BE,Ismaili T,Swigart PM,Raghunathan A,Baker AJ,Sahdeo S,Blevitt JM,Milla ME,Simpson PC

更新日期：2019-09-13 00:00:00

abstract：:The lung parenchyma as a tissue has a rather unusual stress-strain relationship. A theoretical derivation of this relationship is presented which connects the surface tension and the tissue elastic stress in the alveolar septa with the alveolar geometry. The mathematical expression contains a few meaningful physical c...

journal_title：Circulation research

authors： Fung YC

更新日期：1975-10-01 00:00:00

abstract：:Two characteristic features of the rapid component of the cardiac delayed rectifier current (IKr) are prominent inward rectification and an unexpected reduction in activating current with decreased [K+]o. Similar features are observed with heterologous expression of HERG, the gene thought to encode the channel carryin...

journal_title：Circulation research

authors： Yang T,Snyders DJ,Roden DM

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. OBJECTIVE:To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). METHODS ...

journal_title：Circulation research

authors： Wang L,Myles RC,De Jesus NM,Ohlendorf AK,Bers DM,Ripplinger CM

更新日期：2014-04-25 00:00:00

abstract：:Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascular smooth muscle cells (VSMCs). By zymography, OPN and tumor necrosi...

journal_title：Circulation research

authors： Lai CF,Seshadri V,Huang K,Shao JS,Cai J,Vattikuti R,Schumacher A,Loewy AP,Denhardt DT,Rittling SR,Towler DA

更新日期：2006-06-23 00:00:00

abstract：:An affinity gel for the purification of renin was prepared by coupling pepstatin to aminohexylagarose gel. Partially purified human renin (Haas et al., Arch. Biochem. Biophys., 110, 534-543, 1965) was purified further by affinity chromatography on the pepstatin-aminohexyl-agarose gel, gel filtration on a Sephadex G-75...

journal_title：Circulation research

authors： Murakami K,Inagami T,Haas E

更新日期：1977-10-01 00:00:00

abstract：RATIONALE:There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics-related cardiac dysfunction (CTRCD). OBJECTIVE:We aimed to discover new biomarkers associated with doxorubicin- and trastuzumab-induced CTRCD using high-throughput proteomic profil...

journal_title：Circulation research

authors： Beer LA,Kossenkov AV,Liu Q,Luning Prak E,Domchek S,Speicher DW,Ky B

更新日期：2016-10-28 00:00:00

abstract：RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

journal_title：Circulation research

authors： Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

更新日期：2013-06-07 00:00:00

abstract：:Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 ta...

journal_title：Circulation research

authors： Blankenberg S,Godefroy T,Poirier O,Rupprecht HJ,Barbaux S,Bickel C,Nicaud V,Schnabel R,Kee F,Morrison C,Evans A,Lackner KJ,Cambien F,Münzel T,Tiret L,AtheroGene Investigators.

更新日期：2006-07-07 00:00:00

abstract：:The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In gui...

journal_title：Circulation research

authors： Choi BR,Liu T,Salama G

更新日期：2001-03-16 00:00:00

abstract：RATIONALE:Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic ...

journal_title：Circulation research

authors： Li P,Zhu N,Yi B,Wang N,Chen M,You X,Zhao X,Solomides CC,Qin Y,Sun J

更新日期：2013-10-25 00:00:00

abstract：RATIONALE:Higher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ by case fatality are unclear. OBJECTIVES:This study sought to examine the associations between social...

journal_title：Circulation research

authors： Chang SC,Glymour M,Cornelis M,Walter S,Rimm EB,Tchetgen Tchetgen E,Kawachi I,Kubzansky LD

更新日期：2017-06-09 00:00:00

abstract：:We studied alpha- and beta-adrenoceptor-mediated responses of rabbit facial vein rings to adrenergic stimulation to determine the location of the two types of receptors in relation to the sympathetic nerve terminals. Transmural electrical nerve stimulation (TNS) at low frequency elicited large beta-receptor-mediated r...

journal_title：Circulation research

authors： Winquist RJ,Bevan JA

更新日期：1981-08-01 00:00:00

abstract：:Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...

journal_title：Circulation research

authors： Cernadas MR,Sánchez de Miguel L,García-Durán M,González-Fernández F,Millás I,Montón M,Rodrigo J,Rico L,Fernández P,de Frutos T,Rodríguez-Feo JA,Guerra J,Caramelo C,Casado S,López-Farré

更新日期：1998-08-10 00:00:00

abstract：:Disorders of L-type Ca2+ channels can cause severe cardiac arrhythmias. A subclass of small GTP-binding proteins, the RGK family, regulates L-type Ca2+ current (I(Ca,L)) in heterologous expression systems. Among these proteins, Rad (Ras associated with diabetes) is highly expressed in the heart, although its role in t...

journal_title：Circulation research

authors： Yada H,Murata M,Shimoda K,Yuasa S,Kawaguchi H,Ieda M,Adachi T,Murata M,Ogawa S,Fukuda K

更新日期：2007-07-06 00:00:00

abstract：RATIONALE:Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present in human atherosclerotic lesions, their role in atherosclerosis remains elusive. OBJECTIVE:To investigate the role of PDC in atherosclerosis....

journal_title：Circulation research

authors： Daissormont IT,Christ A,Temmerman L,Sampedro Millares S,Seijkens T,Manca M,Rousch M,Poggi M,Boon L,van der Loos C,Daemen M,Lutgens E,Halvorsen B,Aukrust P,Janssen E,Biessen EA

更新日期：2011-12-09 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and, in particular, MMP-9 are important for smooth muscle cell (SMC) migration into the intima. In this study, we sought to determine whether MMP-9 is critical for SMC migration and for the formation of a neointima by using mice in which the gene was deleted (MMP-9(-/-) mice). A denudi...

journal_title：Circulation research

authors： Cho A,Reidy MA

更新日期：2002-11-01 00:00:00

abstract：:Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function. Myocardial and vascular regeneration have been initially proposed as mechanisms of stem cell action. However, in many cases, the frequency of stem cell engraftment and...

journal_title：Circulation research

authors： Gnecchi M,Zhang Z,Ni A,Dzau VJ

更新日期：2008-11-21 00:00:00

abstract：RATIONALE:Dual cell transplantation of cardiac progenitor cells (CPCs) and mesenchymal stem cells (MSCs) after infarction improves myocardial repair and performance in large animal models relative to delivery of either cell population. OBJECTIVE:To demonstrate that CardioChimeras (CCs) formed by fusion between CPCs an...

journal_title：Circulation research

authors： Quijada P,Salunga HT,Hariharan N,Cubillo JD,El-Sayed FG,Moshref M,Bala KM,Emathinger JM,De La Torre A,Ormachea L,Alvarez R Jr,Gude NA,Sussman MA

更新日期：2015-09-25 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:The hypothesis that availability of functional Ca2+ channels in vascular smooth muscle is augmented in hypertension was tested in basilar artery cells from Wistar rats exhibiting stable systolic blood pressure (BPsys) for 2 to 11 weeks after partial renal artery ligation (Goldblatt 2-kidney 1-clip [2K1C] model). Cells...

journal_title：Circulation research

authors： Simard JM,Li X,Tewari K

更新日期：1998-06-29 00:00:00

abstract：:Optimistic people have reduced risk for cardiovascular disease and cardiovascular-related mortality compared with their less optimistic peers. One explanation for this is that optimistic people may be more likely to engage in healthy behavior like exercising frequently, eating fruits and vegetables, and avoiding cigar...

journal_title：Circulation research

authors： Boehm JK,Chen Y,Koga H,Mathur MB,Vie LL,Kubzansky LD

更新日期：2018-04-13 00:00:00

abstract：:The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduced compared with the young adult heart. Since endogenous adenosine exerts an antiadrenergic action in the heart, this study was undertaken to determine if the basal endogenous level of myocardial adenosine increases wit...

journal_title：Circulation research

authors： Dobson JG Jr,Fenton RA,Romano FD

更新日期：1990-05-01 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00