Paradoxical rise in left ventricular filling pressure in the dog during positive end-expiratory pressure ventilation. A reversed Bernheim effect.

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：RATIONALE:Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endo...

journal_title：Circulation research

authors： Sen S,Roy S,Bandyopadhyay G,Scott B,Xiao D,Ramadoss S,Mahata SK,Chaudhuri G

更新日期：2016-08-19 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin re...

journal_title：Circulation research

authors： Ayers CR,Katholi RE,Vaughan ED Jr,Carey RM,Kimbrough HM Jr,Yancey MR,Morton CL

更新日期：1977-03-01 00:00:00

abstract：:Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function. Myocardial and vascular regeneration have been initially proposed as mechanisms of stem cell action. However, in many cases, the frequency of stem cell engraftment and...

journal_title：Circulation research

authors： Gnecchi M,Zhang Z,Ni A,Dzau VJ

更新日期：2008-11-21 00:00:00

abstract：:Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide...

journal_title：Circulation research

authors： Draijer R,Atsma DE,van der Laarse A,van Hinsbergh VW

更新日期：1995-02-01 00:00:00

abstract：:The purpose of these studies was to evaluate cardiovascular structural and functional changes in a model of hypertension-induced myocardial hypertrophy in which vasodilator therapy decreased blood pressure to normal levels. Thus, we determined the separate contributions of hypertension and hypertrophy on myocardial an...

journal_title：Circulation research

authors： Anderson PG,Bishop SP,Digerness SB

更新日期：1989-06-01 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00

abstract：:The molecular identity of receptor-operated, nonselective cation channels (ROCs) of vascular smooth muscle (VSM) cells is not known for certain. Mammalian homologues of the Drosophila canonical transient receptor potential channels (TRPCs) are possible candidates. This study tested the hypothesis that heteromultimeric...

journal_title：Circulation research

authors： Maruyama Y,Nakanishi Y,Walsh EJ,Wilson DP,Welsh DG,Cole WC

更新日期：2006-06-23 00:00:00

abstract：:High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cel...

journal_title：Circulation research

authors： Lüscher TF,Landmesser U,von Eckardstein A,Fogelman AM

更新日期：2014-01-03 00:00:00

abstract：:Although the ultrasonic pulsatility index (PI) is used as a test of arterial inflow, the relationship between proximal arterial stenosis and PI has not been fully evaluated. In a series of experiments on dogs, over 200 measurements of pressure, flow (using an indwelling electromagnetic flowmeter), and PI were made dis...

journal_title：Circulation research

authors： Evans DH,Barrie WW,Asher MJ,Bentley S,Bell PR

更新日期：1980-04-01 00:00:00

abstract：:Although coronary artery spasm has been implicated as an important cause of myocardial ischemia in humans, an animal model of reversible segmental coronary constriction has not been described. To provoke coronary spasm in open-chest dogs, selected vasoconstricting agents adsorbed to viscous ion exchange gels were appl...

journal_title：Circulation research

authors： Pérez JE,Saffitz JE,Gutiérrez FA,Henry PD

更新日期：1983-04-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic...

journal_title：Circulation research

authors： Zhang P,Xu X,Hu X,van Deel ED,Zhu G,Chen Y

更新日期：2007-04-13 00:00:00

abstract：:The deposition of platelets at the site of balloon angioplasty is thought to play a major role in the pathogenesis of restenosis. The antibody AZ-1, which binds to the rabbit platelet glycoprotein IIb/IIIa receptor and inhibits platelet function both in vitro and in vivo, was produced and tested in an experimental mod...

journal_title：Circulation research

authors： Azrin MA,Ling FS,Chen Q,Pawashe A,Migliaccio F,Homer R,Todd M,Ezekowitz MD

更新日期：1994-08-01 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:Neuropeptide Y is stored in sympathetic nerve terminals throughout the heart and has direct and indirect effects on cardiac function. Although neuropeptide Y has been shown to be released upon intense (16-30 Hz) cardiac sympathetic stimulation, we sought to determine whether effective quantities of neuropeptide Y were...

journal_title：Circulation research

authors： Warner MR,Levy MN

更新日期：1989-05-01 00:00:00

abstract：:To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded ...

journal_title：Circulation research

authors： Shimokawa H,Aarhus LL,Vanhoutte PM

更新日期：1987-08-01 00:00:00

abstract：:High sodium intake (HNa) increases brain ouabainlike activity (OLA) in rats. In spontaneously hypertensive rats (SHR), HNa exaggerates development of hypertension and pressor and sympathoexcitatory responses to stress. To investigate whether dietary sodium-induced changes in brain OLA play a functional role, responses...

journal_title：Circulation research

authors： Huang BS,Leenen FH

更新日期：1992-02-01 00:00:00

abstract：:We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic ao...

journal_title：Circulation research

authors： Yellin EL,Yoran C,Sonnenblick EH,Gabbay S,Frater RW

更新日期：1979-11-01 00:00:00

abstract：:To delineate more clearly the importance of altered monovalent cation transport rate in the mediation of the positive inotropic effects of cardiac glycosides, we studied changes in the contractile state and rate of uptake of K+ and Rb+ by monolayer cultures of chick embryo ventricular cells during exposure to and wash...

journal_title：Circulation research

authors： Barry WH,Biedert S,Miura DS,Smith TW

更新日期：1981-07-01 00:00:00

abstract：:Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during s...

journal_title：Circulation research

authors： Fallavollita JA,Malm BJ,Canty JM Jr

更新日期：2003-01-10 00:00:00

abstract：:Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila. The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow...

journal_title：Circulation research

authors： Shukla S,Fisher SA

更新日期：2008-08-29 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：:Bone morphogenetic protein receptor 2 (BMPR2) mutations have been linked to familial pulmonary arterial hypertension (PAH), but the molecular pathways leading to this severe pathology remain poorly characterized. We report that hypoxia, a paramount stimulus for the development of pulmonary hypertension, suppresses the...

journal_title：Circulation research

authors： Wu X,Chang MS,Mitsialis SA,Kourembanas S

更新日期：2006-08-04 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors controlling lipid and glucose metabolism as well as inflammation. PPARs are expressed in macrophages, cells that also generate reactive oxygen species (ROS). In this study, we investigated whether PPARs regulate ROS production in macrophages. Di...

journal_title：Circulation research

authors： Teissier E,Nohara A,Chinetti G,Paumelle R,Cariou B,Fruchart JC,Brandes RP,Shah A,Staels B

更新日期：2004-12-10 00:00:00

abstract：:The hypothesis that alpha-adrenergic coronary vasoconstriction helps maintain a uniform transmural distribution of myocardial blood flow during exercise was tested in dogs. Carotid artery loops were surgically constructed and a splenectomy performed three weeks prior to study. On the day of study, the dog was anesthet...

journal_title：Circulation research

authors： Huang AH,Feigl EO

更新日期：1988-02-01 00:00:00

abstract：:The SCN5A gene encodes the alpha subunit of the human heart sodium channel (hH1), which plays a critical role in cardiac excitability. Mutations of SCN5A underlie Brugada syndrome, an inherited disorder that leads to ventricular fibrillation and sudden death. This study describes changes in cellular localization and f...

journal_title：Circulation research

authors： Baroudi G,Pouliot V,Denjoy I,Guicheney P,Shrier A,Chahine M

更新日期：2001-06-22 00:00:00