Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic ves

abstract：:Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

journal_title：Circulation research

authors： Joly GA,Schini VB,Vanhoutte PM

更新日期：1992-08-01 00:00:00

abstract：:The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and a...

journal_title：Circulation research

authors： Clarke RH,Isner JM,Donaldson RF,Jones G 2nd

更新日期：1987-03-01 00:00:00

abstract：:Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

journal_title：Circulation research

authors： Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

更新日期：2009-04-10 00:00:00

abstract：:In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor. In humans, aldosterone causes MR-dependent endothelial cell (EC) dysfunction...

journal_title：Circulation research

authors： Caprio M,Newfell BG,la Sala A,Baur W,Fabbri A,Rosano G,Mendelsohn ME,Jaffe IZ

更新日期：2008-06-06 00:00:00

abstract：:Whereas numerous studies have investigated the role of prostacyclin and thromboxane A2 in the maintenance of coronary blood flow, most of these have focused on normal vessels. In the present investigation, we examined the prostaglandin- and thromboxane-synthesizing capacity of isolated coronary artery segments obtaine...

journal_title：Circulation research

authors： Schmitz JM,Apprill PG,Buja LM,Willerson JT,Campbell WB

更新日期：1985-08-01 00:00:00

abstract：RATIONALE:Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translat...

journal_title：Circulation research

authors： Haubner BJ,Schneider J,Schweigmann U,Schuetz T,Dichtl W,Velik-Salchner C,Stein JI,Penninger JM

更新日期：2016-01-22 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates optimal force transduction, electric transmission, intercellular communication, and metabolic exchange within the myocardial microenvir...

journal_title：Circulation research

authors： Li AH,Liu PP,Villarreal FJ,Garcia RA

更新日期：2014-02-28 00:00:00

abstract：:Choline acetyltransferase is the enzyme that catalyzes the biosynthesis of acetylcholine, the neurotransmitter of the pre- and postganglionic parasympathetic system. To assess the extent of parasympathetic innervation, enzyme activity was measured in specialized and contractile regions throughout the guinea pig heart....

journal_title：Circulation research

authors： Schmid PG,Greif BJ,Lund DD,Roskoski R Jr

更新日期：1978-05-01 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：:Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca2+-dependent inactivation/adaptation and luminal Ca2+-dependen...

journal_title：Circulation research

authors： Terentyev D,Viatchenko-Karpinski S,Valdivia HH,Escobar AL,Györke S

更新日期：2002-09-06 00:00:00

abstract：:Electrical uncoupling at gap junctions during acute myocardial ischemia contributes to conduction abnormalities and reentrant arrhythmias. Increased levels of intracellular Ca(2+) and H(+) and accumulation of amphipathic lipid metabolites during ischemia promote uncoupling, but other mechanisms may play a role. We tes...

journal_title：Circulation research

authors： Beardslee MA,Lerner DL,Tadros PN,Laing JG,Beyer EC,Yamada KA,Kléber AG,Schuessler RB,Saffitz JE

更新日期：2000-10-13 00:00:00

abstract：:Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality b...

journal_title：Circulation research

authors： West J,Fagan K,Steudel W,Fouty B,Lane K,Harral J,Hoedt-Miller M,Tada Y,Ozimek J,Tuder R,Rodman DM

更新日期：2004-04-30 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：:The potential for exogenous infusion of basic fibroblast growth factor (bFGF) to increase collateral blood flow to dependent tissue was quantified in adult male rats with peripheral arterial insufficiency. Occlusion of the femoral artery at a proximal site did not infringe on resting blood flow to the distal hindlimb ...

journal_title：Circulation research

authors： Yang HT,Deschenes MR,Ogilvie RW,Terjung RL

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:In the myocardium, redox/cysteine modification of proteins regulating Ca(2+) cycling can affect contraction and may have therapeutic value. Nitroxyl (HNO), the one-electron-reduced form of nitric oxide, enhances cardiac function in a manner that suggests reversible cysteine modifications of the contractile ma...

journal_title：Circulation research

authors： Gao WD,Murray CI,Tian Y,Zhong X,DuMond JF,Shen X,Stanley BA,Foster DB,Wink DA,King SB,Van Eyk JE,Paolocci N

更新日期：2012-09-28 00:00:00

abstract：:Effects of blood flow on the production of prostacyclin (PGI2) were examined in the canine femoral artery perfused ex vivo. Each artery was perfused in situ with medium 199, under conditions of simulated blood flow. To simulate the normal and abnormal blood flow waveforms at the same mean flow rate, we developed a flo...

journal_title：Circulation research

authors： Onohara T,Okadome K,Yamamura S,Mii S,Sugimachi K

更新日期：1991-04-01 00:00:00

abstract：RATIONALE:Flecainide, a class 1c antiarrhythmic, has emerged as an effective therapy in preventing arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) refractory to β-adrenergic receptor blockade. It has been proposed that the clinical efficacy of flecainide in CPVT is because of t...

journal_title：Circulation research

authors： Bannister ML,Thomas NL,Sikkel MB,Mukherjee S,Maxwell C,MacLeod KT,George CH,Williams AJ

更新日期：2015-04-10 00:00:00

abstract：:Cyclosporine A (CsA)-induced hypertension appears to be caused in part by neurogenic vasoconstriction, but the mechanism by which CsA activates the sympathetic nervous system is unknown. In T lymphocytes, the cellular target of CsA and the macrolide immunosuppressant FK506 (as complexes with their endogenous cytoplasm...

journal_title：Circulation research

authors： Lyson T,Ermel LD,Belshaw PJ,Alberg DG,Schreiber SL,Victor RG

更新日期：1993-09-01 00:00:00

abstract：:A narrow zone of block in isolated false tendon preparations was created by perfusion of the central compartment (gap) of a three-compartment tissue bath with either an isotonic sucrose solution or a solution designed to mimic the extracellular milieu in ischemic tissue. Driven responses on the proximal side of the ga...

journal_title：Circulation research

authors： Antzelevitch C,Moe GK

更新日期：1981-11-01 00:00:00

abstract：:The introduction of statins ≈ 30 years ago ushered in the era of lipid lowering as the most effective way to reduce risk of atherosclerotic cardiovascular disease. Nonetheless, residual risk remains high, and statin intolerance is frequently encountered in clinical practice. After a long dry period, the field of thera...

journal_title：Circulation research

authors： Shapiro MD,Fazio S

更新日期：2016-02-19 00:00:00

abstract：:An animal model was used to test the hypothesis that in heart failure the decrease in the ability to resynthesize ATP through the creatine kinase (CK) reaction (which we call energy reserve) contributes to the inability of the heart to maintain its normal function and contractile reserve. One-week-old turkey poults we...

journal_title：Circulation research

authors： Liao R,Nascimben L,Friedrich J,Gwathmey JK,Ingwall JS

更新日期：1996-05-01 00:00:00

abstract：:The aim of this study was to examine the effect of exercise training on reflex control of vascular resistance in human males. Forearm vascular responses to lower body negative pressure (LBNP) at -10 and -40 mm Hg were compared between highly trained young athletes (21.5 +/- 0.5 years old, n = 14) and age-matched nonat...

journal_title：Circulation research

authors： Takeshita A,Jingu S,Imaizumi T,Kunihiko Y,Koyanagi S,Nakamura M

更新日期：1986-07-01 00:00:00

abstract：RATIONALE:The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms, most are located within regulatory intergenic or intronic sequence...

journal_title：Circulation research

authors： Vincentz JW,Firulli BA,Toolan KP,Arking DE,Sotoodehnia N,Wan J,Chen PS,de Gier-de Vries C,Christoffels VM,Rubart-von der Lohe M,Firulli AB

更新日期：2019-08-30 00:00:00

abstract：:Increasing attention is currently devoted to the multiple roles that pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascular homeostasis, and pathology. Many recent excellent reviews thoroughly address these topics (see below); hence, we will not discuss them in detail h...

journal_title：Circulation research

authors： Cappellari O,Cossu G

更新日期：2013-07-19 00:00:00

abstract：:Vagal afferents from the cardiopulmonary region exert a tonic inhibition on the vasomotor center. This is demonstrated by constriction of systemic resistance and splanchnic capacitance vessels and by increased output of renin when the vagi are cut or blocked. In dogs, removal or selective denervation of organs showed ...

journal_title：Circulation research

authors： Thorén PN,Donald DE,Shepherd JT

更新日期：1976-06-01 00:00:00

abstract：:We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E-deficient (apoE-/-) mice treated with angiotensin II (Ang II). In the present study, we tested the hypothesis that uPA is essential for AAA form...

journal_title：Circulation research

authors： Deng GG,Martin-McNulty B,Sukovich DA,Freay A,Halks-Miller M,Thinnes T,Loskutoff DJ,Carmeliet P,Dole WP,Wang YX

更新日期：2003-03-21 00:00:00

abstract：:Inherited restrictive cardiomyopathy (RCM) is a debilitating disease characterized by a stiff heart with impaired ventricular relaxation. Mutations in cardiac troponin I (cTnI) were identified as causal for RCM. Acute genetic engineering of adult cardiac myocytes was used to identify primary structure/function effects...

journal_title：Circulation research

authors： Davis J,Wen H,Edwards T,Metzger JM

更新日期：2007-05-25 00:00:00

abstract：:This study aimed to characterize the interaction between nitric oxide (NO)- and cAMP-related pathways in the control of renal blood flow. Using the isolated perfused rat kidney model, we determined the effects of inhibition of NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME; 1 mmol/L) and of NO administra...

journal_title：Circulation research

authors： Sandner P,Kornfeld M,Ruan X,Arendshorst WJ,Kurtz A

更新日期：1999-02-05 00:00:00

abstract：RATIONALE:ASK1-interacting protein-1 (AIP1), a Ras GTPase-activating protein family member, is highly expressed in endothelial cells and vascular smooth musccells (VSMCs). The role of AIP1 in VSMCs and VSMC proliferative disease is not known. OBJECTIVE:We used mouse graft arteriosclerosis models characterized by VSMC ...

journal_title：Circulation research

authors： Yu L,Qin L,Zhang H,He Y,Chen H,Pober JS,Tellides G,Min W

更新日期：2011-08-05 00:00:00