Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction.

abstract：:We studied alpha- and beta-adrenoceptor-mediated responses of rabbit facial vein rings to adrenergic stimulation to determine the location of the two types of receptors in relation to the sympathetic nerve terminals. Transmural electrical nerve stimulation (TNS) at low frequency elicited large beta-receptor-mediated r...

journal_title：Circulation research

authors： Winquist RJ,Bevan JA

更新日期：1981-08-01 00:00:00

abstract：:Cardiovascular disease continues to be the leading cause of death among women in the United States, accounting for ≈1 of every 3 female deaths. Sex-specific data focused on cardiovascular disease have been increasing steadily, yet is not routinely collected nor translated into practice. This comprehensive review focus...

journal_title：Circulation research

authors： Garcia M,Mulvagh SL,Merz CN,Buring JE,Manson JE

更新日期：2016-04-15 00:00:00

abstract：:We examined whether albumin-derived advanced glycosylation end products (AGEs) downregulate the expression of endothelial nitric oxide synthase (NOS). Significant reductions in NOS activity and cGMP levels in bovine aortic endothelial cells were observed when exposed to different concentrations of albumin-derived AGEs...

journal_title：Circulation research

authors： Rojas A,Romay S,González D,Herrera B,Delgado R,Otero K

更新日期：2000-02-18 00:00:00

abstract：:We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system whic...

journal_title：Circulation research

authors： Sanchez-Chapula J,Tsuda Y,Josephson IR

更新日期：1983-05-01 00:00:00

abstract：:Sinus node recovery time was compared to the recovery time of a slow atrioventricular junctional rhythm in each of the same seven pentobarbital anesthetized dogs. Recovery time and the first five cardiac cycles were examined after pacing atria and ventricles for 20, 40, and 60 seconds at four or more pacing cycle leng...

journal_title：Circulation research

authors： Neely BH,Urthaler F,Hageman GR

更新日期：1985-07-01 00:00:00

abstract：:The alpha-adrenergic blocking drugs, phentolamine and Hydergine, both act centrally at different sites to depress and enhance the pressor and sympathetic nerve response to decreased baroreceptor afferent input in anesthetized cats. Depression of the rise in blood pressure and sympathetic nerve discharge during bilater...

journal_title：Circulation research

authors： Tadepalli AS,Mills E,Schanberg SM

更新日期：1976-11-01 00:00:00

abstract：:We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic d...

journal_title：Circulation research

authors： Clark EB,Hu N

更新日期：1982-12-01 00:00:00

abstract：:An improved assay was used to investigate the effects of hypoxia or ischemia on interstitial fluid and coronary venous effluent levels of adenosine in isolated perfused nonworking rat hearts. The adenosine in 5- to 10-microliter samples of left ventricular epicardial surface transudates and coronary effluents was reac...

journal_title：Circulation research

authors： Fenton RA,Dobson JG Jr

更新日期：1987-02-01 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:Coronary pressure-flow relations during autoregulated and vasodilated flow states were compared between eight dogs with renovascular hypertension and left ventricular hypertrophy and 12 normal dogs. Each relation was constructed from serial steady-state measurements of end-diastolic coronary pressure and flow during p...

journal_title：Circulation research

authors： Jeremy RW,Fletcher PJ,Thompson J

更新日期：1989-07-01 00:00:00

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:Using alpha-chloralose-anesthetized cats, we studied blood pressure and heart rate responses to static contraction and passive stretch of the triceps surae muscle before and after microdialyzing the mu-opioid agonist [D-Ala2]-methionine enkephalinamide (DAME, 200 mumol/L) into the L-7 dorsal horn of the spinal cord. I...

journal_title：Circulation research

authors： Meintjes AF,Nóbrega AC,Fuchs IE,Ally A,Wilson LB

更新日期：1995-08-01 00:00:00

abstract：:The potential for exogenous infusion of basic fibroblast growth factor (bFGF) to increase collateral blood flow to dependent tissue was quantified in adult male rats with peripheral arterial insufficiency. Occlusion of the femoral artery at a proximal site did not infringe on resting blood flow to the distal hindlimb ...

journal_title：Circulation research

authors： Yang HT,Deschenes MR,Ogilvie RW,Terjung RL

更新日期：1996-07-01 00:00:00

abstract：:Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent s...

journal_title：Circulation research

authors： Shiraishi I,Melendez J,Ahn Y,Skavdahl M,Murphy E,Welch S,Schaefer E,Walsh K,Rosenzweig A,Torella D,Nurzynska D,Kajstura J,Leri A,Anversa P,Sussman MA

更新日期：2004-04-16 00:00:00

abstract：:By making use of immunoblotting and immunocytochemical analysis, we explored whether stimulation of adenosine A1 receptors would promote the activation of delta-protein kinase C (delta-PKC) immunolabeled with a polyclonal antibody. Immunoblot analysis of Triton X-100-soluble cell membrane and cytosolic fractions revea...

journal_title：Circulation research

authors： Henry P,Demolombe S,Pucéat M,Escande D

更新日期：1996-01-01 00:00:00

abstract：:Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to b...

journal_title：Circulation research

authors： Weinstock A,Moura Silva H,Moore KJ,Schmidt AM,Fisher EA

更新日期：2020-05-22 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：:Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during ath...

journal_title：Circulation research

authors： Franco C,Hou G,Ahmad PJ,Fu EY,Koh L,Vogel WF,Bendeck MP

更新日期：2008-05-23 00:00:00

abstract：:To gain some insight into inotropic mechanisms, we compared the effects of several classes of inotropic interventions on the isometric twitch and force-velocity properties of isolated rabbit myocardium. Postextrasystolic potentiation was chosen as one of the interventions in the belief that its onset is so rapid that ...

journal_title：Circulation research

authors： Chiu YC,Walley KR,Ford LE

更新日期：1989-11-01 00:00:00

abstract：:High sodium intake (HNa) increases brain ouabainlike activity (OLA) in rats. In spontaneously hypertensive rats (SHR), HNa exaggerates development of hypertension and pressor and sympathoexcitatory responses to stress. To investigate whether dietary sodium-induced changes in brain OLA play a functional role, responses...

journal_title：Circulation research

authors： Huang BS,Leenen FH

更新日期：1992-02-01 00:00:00

abstract：:Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriogr...

journal_title：Circulation research

authors： Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1992-03-01 00:00:00

abstract：:Electrocardiogram (ECG) electrodes and carotid arterial and superior vena caval (SVC) catheters were placed in eight nonpregnant ewes and 11 fetuses (109-129 days gestation) to measure heart rate, arterial presssure, P-R interval, left ventricular pre-ejection period (PEP), and left ventricular ejection time (LVET), b...

journal_title：Circulation research

authors： Berman W Jr,Ravenscroft PJ,Sheiner LB,Heymann MA,Melmon KL,Rudolph AM

更新日期：1977-11-01 00:00:00

abstract：:In our morphometric study of the effects of exercise on the heart, male Wistar-Kyoto rats at 5 weeks of age were subjected daily to a moderate treadmill running program that lasted for 7 weeks. The heart responded to physical conditioning by different magnitudes of tissue growth of the right (22%) and left (7%) ventri...

journal_title：Circulation research

authors： Anversa P,Levicky V,Beghi C,McDonald SL,Kikkawa Y

更新日期：1983-01-01 00:00:00

abstract：:We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E-deficient (apoE-/-) mice treated with angiotensin II (Ang II). In the present study, we tested the hypothesis that uPA is essential for AAA form...

journal_title：Circulation research

authors： Deng GG,Martin-McNulty B,Sukovich DA,Freay A,Halks-Miller M,Thinnes T,Loskutoff DJ,Carmeliet P,Dole WP,Wang YX

更新日期：2003-03-21 00:00:00

abstract：:Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in mouse heart stimulates the bigenomic mitochondrial biogenesis pr...

journal_title：Circulation research

authors： Piantadosi CA,Carraway MS,Babiker A,Suliman HB

更新日期：2008-11-21 00:00:00

abstract：:The role of the Na+-Ca2+ exchanger as a major determinant of cell Ca2+ is well defined in cardiac tissue, and there has been much effort to develop specific inhibitors of the exchanger. We use a novel system to test the specificity of two putative specific inhibitors, KB-R7943 and SEA0400. The drugs are applied to ele...

journal_title：Circulation research

authors： Reuter H,Henderson SA,Han T,Matsuda T,Baba A,Ross RS,Goldhaber JI,Philipson KD

更新日期：2002-07-26 00:00:00

abstract：:Previous studies have suggested that intravenous infusion of arginine vasopressin (AVP) inhibits sympathetic nerve activity (SNA) in rabbits by its action at the brainstem. This study aimed to determine, first, whether this action of AVP depended on functioning baroreflex mechanisms. The second aim was to determine th...

journal_title：Circulation research

authors： Suzuki S,Takeshita A,Imaizumi T,Hirooka Y,Yoshida M,Ando S,Nakamura M

更新日期：1989-11-01 00:00:00

abstract：RATIONALE:PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. OBJECTIVE:Here...

journal_title：Circulation research

authors： Rykaczewska U,Suur BE,Röhl S,Razuvaev A,Lengquist M,Sabater-Lleal M,van der Laan SW,Miller CL,Wirka RC,Kronqvist M,Gonzalez Diez M,Vesterlund M,Gillgren P,Odeberg J,Lindeman JH,Veglia F,Humphries SE,de Faire U,Baldass

更新日期：2020-02-28 00:00:00

abstract：RATIONALE:Post-myocardial infarction ventricular remodeling is associated with the expression of a variety of factors including S100B that can potentially modulate myocyte apoptosis. OBJECTIVE:This study was undertaken to investigate the expression and function of S100B and its receptor, the receptor for advanced glyc...

journal_title：Circulation research

authors： Tsoporis JN,Izhar S,Leong-Poi H,Desjardins JF,Huttunen HJ,Parker TG

更新日期：2010-01-08 00:00:00