Abstract:
:The alpha-adrenergic blocking drugs, phentolamine and Hydergine, both act centrally at different sites to depress and enhance the pressor and sympathetic nerve response to decreased baroreceptor afferent input in anesthetized cats. Depression of the rise in blood pressure and sympathetic nerve discharge during bilateral carotid occlusion (BCO) followed injection of the agents into the 4th cerebral ventricle when the brain was intact but not when connections were interrupted at the midcollicular level by transection or lesion. Enhancement of responses occurred when drug distribution was confined to the brain rostral to the midcollicular level via injection into the 3rd cerebral ventricle with the cerebral aqueduct cannulated. Both agents decreased resting blood pressure and Hydergine decreased heart rate in intact and decerebrate preparations but not in 3rd ventricle-cerebral aqueduct experiments. We found that pretreatment with the noradrenergic precursor. L-dopa consistently prevented depression by phentolamine but was less effective against Hydergine. The results indicate that mechanisms which enhance and suppress the baroreceptor pressor response are normally operative in anesthetized cats and, furthermore, that neural pathways mediating the effects are ones connecting the caudal brainstem with supracollicular levels of the brain. It is further suggested that the pathways may be noradrenergic.
journal_name
Circ Resjournal_title
Circulation researchauthors
Tadepalli AS,Mills E,Schanberg SMdoi
10.1161/01.res.39.5.724subject
Has Abstractpub_date
1976-11-01 00:00:00pages
724-30issue
5eissn
0009-7330issn
1524-4571journal_volume
39pub_type
杂志文章abstract::Studies were performed to determine whether an alteration in coronary vascular resistance and a reduction in the reflow phenomenon occurred in the blood-perfused, heparinized canine heart after various periods of myocaridal ischemia. Regional myocardial blood flow was measured with radioactive microspheres. Proximal l...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.36.6.771
更新日期:1975-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.61.1.42
更新日期:1987-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.206946
更新日期:2010-02-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.84.1.9
更新日期:1999-01-08 00:00:00
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pub_type: 杂志文章
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更新日期:2001-03-16 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.112.273375
更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000191538.76771.66
更新日期:2005-11-25 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000054624.03539.b4
更新日期:2003-02-07 00:00:00
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pub_type: 杂志文章
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更新日期:2003-08-08 00:00:00
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pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.65.5.1370
更新日期:1989-11-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.75.4.637
更新日期:1994-10-01 00:00:00
abstract::Net cellular L-lactate efflux associated with accelerated anaerobic glycolysis has been implicated as a potential cause of the marked cellular K+ loss contributing to lethal cardiac arrhythmias in ischemic heart and to impaired function of fatigued skeletal muscle. To examine the mechanisms of transsarcolemmal L-lacta...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.74.5.829
更新日期:1994-05-01 00:00:00
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journal_title:Circulation research
pub_type: 评审
doi:10.1161/CIRCRESAHA.120.316203
更新日期:2020-05-22 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.65.3.600
更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.53.2.202
更新日期:1983-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.107.160176
更新日期:2008-02-15 00:00:00
abstract:RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...
journal_title:Circulation research
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCRESAHA.118.314500
更新日期:2019-05-10 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.110.222364
更新日期:2010-10-29 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.62.6.1059
更新日期:1988-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000141528.54850.bd
更新日期:2004-09-17 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.5.403
更新日期:1999-09-03 00:00:00
abstract::The goals of this article were (1) to identify cell surface proteins whose expression was regulated by diabetes and (2) to assess their contribution to diabetic complications. We purified heat shock protein 90alpha (Hsp90alpha) from the membrane fraction of high glucose-treated endothelial cells (ECs) as a binding par...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000124979.46214.E3
更新日期:2004-04-16 00:00:00
abstract:RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.240655
更新日期:2011-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.RES.0000116143.74830.A9
更新日期:2004-02-20 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.116.303641
更新日期:2015-03-13 00:00:00
abstract::In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.2.376
更新日期:1992-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.62.6.1111
更新日期:1988-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.112.300754
更新日期:2013-04-12 00:00:00
abstract::It is known that branching strands of cardiac tissue can form a substrate for very slow conduction. The branches slow conduction by acting as current loads drawing depolarizing current from the main strand ("pull" effect). It has been suggested that, upon depolarization of the branches, they become current sources rei...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/hh2101.098442
更新日期:2001-10-26 00:00:00