Gas chromatographic-light microscopic correlative analysis of excimer laser photoablation of cardiovascular tissues: evidence for a thermal mechanism.

abstract：RATIONALE:The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during tumor growth has long suggested that the endothelial expression of this molecule is an ideal target for antiangiogenic therapy to treat cancer. This discovery led to the development of small-molecule inhibitors directed against α...

journal_title：Circulation research

authors： Steri V,Ellison TS,Gontarczyk AM,Weilbaecher K,Schneider JG,Edwards D,Fruttiger M,Hodivala-Dilke KM,Robinson SD

更新日期：2014-01-03 00:00:00

abstract：:The effects of sodium pump inhibition produced by exposure to the cardiac glycosides, ouabain or dihydroouabain, or by reduction in extracellular potassium to 1.0 mM, on contractile state and sodium-calcium exchange were studied in primary monolayer cultures of chick embryo ventricular cells. Ouabain, 10(-6)M, dihydro...

journal_title：Circulation research

authors： Barry WH,Hasin Y,Smith TW

更新日期：1985-02-01 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Protein kinase (PK)C-induced phosphorylation of cardiac troponin (cTn)I has been shown to regulate cardiac contraction. OBJECTIVE:Characterize functional effects of increased PKC-induced cTnI phosphorylation and identify underlying mechanisms using a transgenic mouse model (cTnI(PKC-P)) expressing mutant cTn...

journal_title：Circulation research

authors： Kirk JA,MacGowan GA,Evans C,Smith SH,Warren CM,Mamidi R,Chandra M,Stewart AF,Solaro RJ,Shroff SG

更新日期：2009-12-04 00:00:00

abstract：:Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Locke's solution or rabbit blood) could be contr...

journal_title：Circulation research

authors： Qu L,Stuesse SL

更新日期：1991-12-01 00:00:00

abstract：RATIONALE:Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications controlling its activation. OBJECTIVE:To determine whether posttran...

journal_title：Circulation research

authors： Streeter J,Schickling BM,Jiang S,Stanic B,Thiel WH,Gakhar L,Houtman JC,Miller FJ Jr

更新日期：2014-11-07 00:00:00

abstract：:In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhib...

journal_title：Circulation research

authors： Gittenberger-de Groot AC,Vrancken Peeters MP,Bergwerff M,Mentink MM,Poelmann RE

更新日期：2000-11-24 00:00:00

abstract：:Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally develop severe pulmonary vascular obstructive disease. To understand what underlies this propensity, we compared the pulmonary vascular hemodynamic and structural features of S100A4/Mts1 with control C57Bl/6 mice at baseline, followi...

journal_title：Circulation research

authors： Merklinger SL,Wagner RA,Spiekerkoetter E,Hinek A,Knutsen RH,Kabir MG,Desai K,Hacker S,Wang L,Cann GM,Ambartsumian NS,Lukanidin E,Bernstein D,Husain M,Mecham RP,Starcher B,Yanagisawa H,Rabinovitch M

更新日期：2005-09-16 00:00:00

abstract：:Many cell types undergo apoptosis under conditions of ischemia. Little is known, however, about the molecular pathways that mediate this response. A cellular and biochemical approach to elucidate such signaling pathways was undertaken in primary cultures of cardiac myocytes, a cell type that is especially sensitive to...

journal_title：Circulation research

authors： Bialik S,Cryns VL,Drincic A,Miyata S,Wollowick AL,Srinivasan A,Kitsis RN

更新日期：1999-09-03 00:00:00

abstract：RATIONALE:There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics-related cardiac dysfunction (CTRCD). OBJECTIVE:We aimed to discover new biomarkers associated with doxorubicin- and trastuzumab-induced CTRCD using high-throughput proteomic profil...

journal_title：Circulation research

authors： Beer LA,Kossenkov AV,Liu Q,Luning Prak E,Domchek S,Speicher DW,Ky B

更新日期：2016-10-28 00:00:00

abstract：RATIONALE:Mutations in vascular endothelial growth factor (VEGF) receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients with classic Milroy disease, suggesting genetic heterogeneity. OBJECTIV...

journal_title：Circulation research

authors： Gordon K,Schulte D,Brice G,Simpson MA,Roukens MG,van Impel A,Connell F,Kalidas K,Jeffery S,Mortimer PS,Mansour S,Schulte-Merker S,Ostergaard P

更新日期：2013-03-15 00:00:00

abstract：:The possibility of an interaction between the cytoskeletal protein dystrophin and cell surface caveolae in the mammalian myocardium was investigated by several techniques. Caveolin (cav)-3-enriched, detergent-insoluble membranes isolated from purified ventricular sarcolemma by density-gradient fractionation were found...

journal_title：Circulation research

authors： Doyle DD,Goings G,Upshaw-Earley J,Ambler SK,Mondul A,Palfrey HC,Page E

更新日期：2000-09-15 00:00:00

abstract：:Endocardial endothelium and endothelium of coronary vessels produce NO. Histochemical methods have suggested that coronary arterial endothelial cells contain more endothelial constitutive NO synthase (ecNOS) than does coronary venous endothelium. We have further investigated the distribution of ecNOS in cardiac endoth...

journal_title：Circulation research

authors： Andries LJ,Brutsaert DL,Sys SU

更新日期：1998-02-09 00:00:00

abstract：RATIONALE:Obesity leads to increased ischemic heart disease (IHD) risk, but the risk is thought to be mediated through intermediate variables and may not be caused by increased weight per se. OBJECTIVE:To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressur...

journal_title：Circulation research

authors： Varbo A,Benn M,Smith GD,Timpson NJ,Tybjaerg-Hansen A,Nordestgaard BG

更新日期：2015-02-13 00:00:00

abstract：:Muscle ring finger (MuRF) proteins have been implicated in transmitting mechanical forces to cell signaling pathways through their interactions with the giant protein titin. Recent evidence has linked mechanically-induced stimuli with the control of serum response factor activity and localization through MuRF2. This o...

journal_title：Circulation research

authors： Willis MS,Ike C,Li L,Wang DZ,Glass DJ,Patterson C

更新日期：2007-03-02 00:00:00

abstract：:The potential for exogenous infusion of basic fibroblast growth factor (bFGF) to increase collateral blood flow to dependent tissue was quantified in adult male rats with peripheral arterial insufficiency. Occlusion of the femoral artery at a proximal site did not infringe on resting blood flow to the distal hindlimb ...

journal_title：Circulation research

authors： Yang HT,Deschenes MR,Ogilvie RW,Terjung RL

更新日期：1996-07-01 00:00:00

abstract：:Early afterdepolarizations (EADs) are a type of triggered activity found in heart muscle. We used voltage-clamped sheep cardiac Purkinje fibers to examine the mechanism underlying EADs induced near action potential plateau voltages with the Ca2+ current agonist Bay K 8644 and the effect of several interventions known ...

journal_title：Circulation research

authors： January CT,Riddle JM

更新日期：1989-05-01 00:00:00

abstract：RATIONALE:Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. OBJECTIV...

journal_title：Circulation research

authors： Porrello ER,Johnson BA,Aurora AB,Simpson E,Nam YJ,Matkovich SJ,Dorn GW 2nd,van Rooij E,Olson EN

更新日期：2011-09-02 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals. After stimulation of the cardiac sympathetic nerves in anesthetized dogs, the action of the vagus nerve on heart...

journal_title：Circulation research

authors： Hall GT,Gardner TD,Potter EK

更新日期：1990-07-01 00:00:00

abstract：:The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncod...

journal_title：Circulation research

authors： Cordes KR,Srivastava D

更新日期：2009-03-27 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes...

journal_title：Circulation research

authors： Schmidt AM,Yan SD,Wautier JL,Stern D

更新日期：1999-03-19 00:00:00

abstract：:Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes generated by lipid peroxidation, suggesting that it may serve as an antioxidant defense. To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwent 6 cycles ...

journal_title：Circulation research

authors： Shinmura K,Bolli R,Liu SQ,Tang XL,Kodani E,Xuan YT,Srivastava S,Bhatnagar A

更新日期：2002-08-09 00:00:00

abstract：:Transient coronary occlusion (15 minutes) does not result in irreversible myocardial injury but is associated with a depression of contractile function sustained for several hours to days ("stunned myocardium"). The defect in the contractile process responsible for this phenomenon has been suggested to be causally rel...

journal_title：Circulation research

authors： Ito BR,Tate H,Kobayashi M,Schaper W

更新日期：1987-12-01 00:00:00

abstract：:The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...

journal_title：Circulation research

authors： Mak IT,Arroyo CM,Weglicki WB

更新日期：1989-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a recently discovered class of endogenous, small, noncoding RNAs that regulate about 30% of the encoding genes of the human genome. However, the role of miRNAs in vascular disease is currently completely unknown. Using microarray analysis, we demonstrated for the first time that miRNAs are aberr...

journal_title：Circulation research

authors： Ji R,Cheng Y,Yue J,Yang J,Liu X,Chen H,Dean DB,Zhang C

更新日期：2007-06-08 00:00:00

abstract：RATIONALE:Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. OBJECTIVE:To investigate the mechanism by which FGF signaling regulates cardiac progenitor cell differentiation. ME...

journal_title：Circulation research

authors： Zhang J,Liu J,Huang Y,Chang JY,Liu L,McKeehan WL,Martin JF,Wang F

更新日期：2012-02-17 00:00:00

abstract：:After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable st...

journal_title：Circulation research

authors： Ito CS,Scher AM

更新日期：1979-07-01 00:00:00

abstract：:Patients with diabetes mellitus have >2× the risk for developing heart failure (HF; HF with reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular outcomes, hospitalization, and prognosis are worse for patients with diabetes mellitus relative to those without. Beyond the structural and func...

journal_title：Circulation research

authors： Kenny HC,Abel ED

更新日期：2019-01-04 00:00:00

abstract：:The paraoxonase (PON) gene cluster consists of the PON1, PON2, and PON3 genes, each of which can individually inhibit atherogenesis. To analyze the functions of the PON gene cluster (PC) in atherogenesis and plaque stability, human PC transgenic (Tg) mice were generated using bacterial artificial chromosome. The high-...

journal_title：Circulation research

authors： She ZG,Zheng W,Wei YS,Chen HZ,Wang AB,Li HL,Liu G,Zhang R,Liu JJ,Stallcup WB,Zhou Z,Liu DP,Liang CC

更新日期：2009-05-22 00:00:00