Abstract:
:In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhibition studies show abnormalities of the compact myocardial layer, myocardialization of cushion tissue, looping, septation, and coronary vascular formation. Lack of epicardial spreading is partly compensated by mesothelial outgrowth over the conotruncal region. Heterospecific epicardial transplant is able to partially rescue the myocardial development, as well as septation and coronary formation.
journal_name
Circ Resjournal_title
Circulation researchauthors
Gittenberger-de Groot AC,Vrancken Peeters MP,Bergwerff M,Mentink MM,Poelmann REdoi
10.1161/01.res.87.11.969subject
Has Abstractpub_date
2000-11-24 00:00:00pages
969-71issue
11eissn
0009-7330issn
1524-4571journal_volume
87pub_type
杂志文章abstract::Mechanisms of denervation supersensitivity to sympathomimetic amines were studied in conscious animals. Norepinephrine, 0.1 micrograms/kg, increased left ventricular dP/dt significantly more (4208 +/- 828 mm Hg/sec) in dogs with cardiac denervation than in intact dogs (1029 +/- 280 mm Hg/sec), P less than 0.01, wherea...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1999-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-01-04 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2004-03-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2011-09-16 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2003-12-12 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.72.5.984
更新日期:1993-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.72.2.424
更新日期:1993-02-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.74.6.1097
更新日期:1994-06-01 00:00:00
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更新日期:1976-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.107.169573
更新日期:2008-04-25 00:00:00
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journal_title:Circulation research
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更新日期:1996-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.66.3.662
更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-08-23 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1975-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-02-19 00:00:00
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pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00