Abstract:
:Platelet activation is markedly increased during coronary thrombolysis and limits the response to thrombolytic therapy. A possible mediator of platelet activation in this setting is thromboxane (TX) A2, a potent platelet agonist formed in greatly increased amounts during coronary thrombolysis in man. To address this hypothesis, we examined the role of TXA2 in modulating the response to intravenous tissue-type plasminogen activator (t-PA) in a chronic canine model of coronary thrombosis. Reperfusion occurred in 60 +/- 5 minutes and was complicated by spontaneous reocclusion. The times to reperfusion and reocclusion were platelet-dependent. Consistent with a role for TXA2 in this process, TXA2 biosynthesis, determined a excretion of its enzymatic metabolite, 2,3-dinor-TXB2, was markedly increased during coronary thrombolysis. Furthermore, inhibition of TXA2 by aspirin, given alone or in combination with a TXA2/prostaglandin endoperoxide receptor antagonist, accelerated reperfusion and partly inhibited cyclic flow variations during reperfusion. The delay in reperfusion and reocclusion induced by TXA2 appeared to be mediated by platelet aggregation since the F(ab')2 fragment of 7E3, a monoclonal antibody to the platelet GPIIb/IIIa, also accelerated reperfusion and prevented reocclusion without altering TXA2 biosynthesis. These finding suggest that platelet aggregation limits the response to coronary thrombolysis and that platelet activation in this setting is partly TXA2-dependent.
journal_name
Circ Resjournal_title
Circulation researchauthors
Fitzgerald DJ,Wright F,FitzGerald GAdoi
10.1161/01.res.65.1.83subject
Has Abstractpub_date
1989-07-01 00:00:00pages
83-94issue
1eissn
0009-7330issn
1524-4571journal_volume
65pub_type
杂志文章abstract:RATIONALE:Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs are unknown. OBJECTIVE:To assess the outcome of CPC therapy at 1 year. METHODS AND...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.307647
更新日期:2016-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1981-11-01 00:00:00
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更新日期:2011-10-28 00:00:00
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更新日期:1981-07-01 00:00:00
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doi:10.1161/CIRCRESAHA.113.301989
更新日期:2013-09-13 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000168650.23479.0c
更新日期:2005-05-27 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.42.1.35
更新日期:1978-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1999-02-05 00:00:00
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pub_type: 杂志文章
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更新日期:2000-02-18 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.6.1057
更新日期:1995-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.50.1.86
更新日期:1982-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.115.307872
更新日期:2016-02-05 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.177105
更新日期:2008-08-29 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.242560
更新日期:2011-07-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCRESAHA.118.314500
更新日期:2019-05-10 00:00:00
abstract::Freshly dispersed rabbit ear artery cells were studied using patch-clamp techniques to measure membrane currents in whole cells and single-channel currents in membrane patches. Whole-cell calcium currents recorded at physiologic extracellular calcium concentrations were small (approximately 10 pA). Recordings with 110...
journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
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更新日期:1988-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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更新日期:2002-11-29 00:00:00
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doi:10.1161/CIRCRESAHA.107.152140
更新日期:2007-10-12 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000184684.88750.FE
更新日期:2005-09-30 00:00:00
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pub_type: 杂志文章
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更新日期:1985-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-11-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.1.9
更新日期:1992-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.172064
更新日期:2008-06-20 00:00:00