The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes.

abstract：:Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular ty...

journal_title：Circulation research

authors： Rahmani M,Cruz RP,Granville DJ,McManus BM

更新日期：2006-10-13 00:00:00

abstract：:Quinidine is the most commonly used drug for the chronic treatment of ventricular arrhythmias, but it may be arrhythmogenic. Much information exists concerning quinidine's effects on active properties in cardiac tissues, but virtually nothing is known of its effects on passive properties. We studied the effects of qui...

journal_title：Circulation research

authors： Arnsdorf MF,Sawicki GJ

更新日期：1987-08-01 00:00:00

abstract：RATIONALE:Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with chronic kidney disease. The nuclear receptor farnesoid X receptor (FXR) has been implicated in the control of lipid, carbohydrate and bile acid metabolism in several cell types. Although recent...

journal_title：Circulation research

authors： Miyazaki-Anzai S,Levi M,Kratzer A,Ting TC,Lewis LB,Miyazaki M

更新日期：2010-06-25 00:00:00

abstract：:The patch clamp technique was used to make whole-cell recordings of calcium channel currents from single muscle cells freshly isolated from rat mesenteric arteries. The cells were found to contain two types of calcium channels; one type is activated by small depolarizations and inactivates quickly, whereas the other r...

journal_title：Circulation research

authors： Bean BP,Sturek M,Puga A,Hermsmeyer K

更新日期：1986-08-01 00:00:00

abstract：:We tested the hypothesis that accumulation of H+ or inorganic phosphate (Pi) is responsible for the early contractile failure of hypoxia by measuring maximal Ca2+-activated pressure and 31P nuclear magnetic resonance spectra in Langendorff-perfused ferret hearts at 30 degrees C. Maximal Ca2+-activated pressure was ide...

journal_title：Circulation research

authors： Kusuoka H,Weisfeldt ML,Zweier JL,Jacobus WE,Marban E

更新日期：1986-09-01 00:00:00

abstract：:Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate, and intracellular pH, all measured by phosphorus-31 nuclear magnetic...

journal_title：Circulation research

authors： Hoerter JA,Miceli MV,Renlund DG,Jacobus WE,Gerstenblith G,Lakatta EG

更新日期：1986-04-01 00:00:00

abstract：RATIONALE:The impact of severe cardiovascular disease and critical limb ischemia (CLI) on the bone marrow (BM) is largely unknown. OBJECTIVE:To investigate microvascular and neuropathic changes in BM of patients with CLI. METHODS AND RESULTS:BM biopsies were obtained from patients with CLI (n=33) included in the Reju...

journal_title：Circulation research

authors： Teraa M,Fledderus JO,Rozbeh RI,Leguit RJ,Verhaar MC,Juventas Study Group{dagger}.

更新日期：2014-01-17 00:00:00

abstract：:This review reflects and expands on the contents of my presentation at the Thomas W. Smith Memorial Lecture at American Heart Association Scientific Sessions, 2011. "Decoding the cardiac message" refers to accumulating results from ongoing microRNA research that is altering longstanding concepts of the mechanisms for,...

journal_title：Circulation research

authors： Dorn GW 2nd

更新日期：2012-03-02 00:00:00

abstract：RATIONALE:Macrophages are essential regulators of atherosclerosis. They secrete cytokines, process lipoproteins and cholesterol, and take up apoptotic cells. Multiple subsets of plaque macrophages exist and their differential roles are emerging. OBJECTIVE:Here, we explore macrophage heterogeneity in atherosclerosis pl...

journal_title：Circulation research

authors： McArdle S,Buscher K,Ghosheh Y,Pramod AB,Miller J,Winkels H,Wolf D,Ley K

更新日期：2019-12-06 00:00:00

abstract：:Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of...

journal_title：Circulation research

authors： Suzuki E,Satonaka H,Nishimatsu H,Oba S,Takeda R,Omata M,Fujita T,Nagai R,Hirata Y

更新日期：2004-07-09 00:00:00

abstract：:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their ...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1976-09-01 00:00:00

abstract：RATIONALE:Giant-cell arteritis (GCA) is a large-vessel vasculitis characterized by immune cell infiltration, yet the potential involvement of neutrophils has rarely been studied. OBJECTIVE:We investigated whether alterations in neutrophil reactivity occurred in the pathogenesis of GCA or during its clinical management...

journal_title：Circulation research

authors： Nadkarni S,Dalli J,Hollywood J,Mason JC,Dasgupta B,Perretti M

更新日期：2014-01-17 00:00:00

abstract：:Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

journal_title：Circulation research

authors： Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

更新日期：2000-11-10 00:00:00

abstract：RATIONALE:Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like lipoprotein and important cardiovascular risk factor whose cognate receptor and intracellular fate remains unknown. OBJECTIVE:Our study aimed to determine the intracellular trafficking pathway for Lp(a) and the receptor responsible for its uptake in li...

journal_title：Circulation research

authors： Sharma M,Redpath GM,Williams MJ,McCormick SP

更新日期：2017-03-31 00:00:00

abstract：:To study the effects of stretch on the function of rat left atrium, we recorded contraction force, calcium transients, and intracellular action potentials (APs) during stretch manipulations. The stretch of the atrium was controlled by intra-atrial pressure. The Frank-Starling behavior of the atrium was manifested as a...

journal_title：Circulation research

authors： Tavi P,Han C,Weckström M

更新日期：1998-11-30 00:00:00

abstract：:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive tri...

journal_title：Circulation research

authors： Perino A,Ghigo A,Scott JD,Hirsch E

更新日期：2012-08-03 00:00:00

abstract：:In recent year, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and ...

journal_title：Circulation research

authors： Uchida S,Dimmeler S

更新日期：2015-02-13 00:00:00

abstract：RATIONALE:Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. OBJECTIVE:We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. METHODS AND RESULTS:Depletion of N...

journal_title：Circulation research

authors： Yan X,Hegab AE,Endo J,Anzai A,Matsuhashi T,Katsumata Y,Ito K,Yamamoto T,Betsuyaku T,Shinmura K,Shen W,Vivier E,Fukuda K,Sano M

更新日期：2014-02-14 00:00:00

abstract：:The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the ra...

journal_title：Circulation research

authors： Schwartz SM,Benditt EP

更新日期：1977-08-01 00:00:00

abstract：RATIONALE:In the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation myocardial infarction and left ventricular (LV) dysfunction after successf...

journal_title：Circulation research

authors： Achilli F,Pontone G,Bassetti B,Squadroni L,Campodonico J,Corrada E,Facchini C,Mircoli L,Esposito G,Scarpa D,Pidello S,Righetti S,Di Gennaro F,Guglielmo M,Muscogiuri G,Baggiano A,Limido A,Lenatti L,Di Tano G,Malafron

更新日期：2019-07-19 00:00:00

abstract：:We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid [EVF]) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were di...

journal_title：Circulation research

authors： Laine GA,Allen SJ

更新日期：1991-06-01 00:00:00

abstract：:Recent studies in isolated cardiac tissue preparations have demonstrated the applicability of a one-dimensional difference equation model describing the global behavior of a driven nonpacemaker cell to the understanding of rate-dependent cardiac excitation. As a first approximation to providing an ionic basis to compl...

journal_title：Circulation research

authors： Vinet A,Chialvo DR,Michaels DC,Jalife J

更新日期：1990-12-01 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and a...

journal_title：Circulation research

authors： Clarke RH,Isner JM,Donaldson RF,Jones G 2nd

更新日期：1987-03-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT)(1B) receptors mediate contraction in human pulmonary arteries, and 5-HT(1B) receptor-mediated contraction is enhanced in pulmonary arteries from hypoxic rats. Here we further examine the role of this receptor in the development of pulmonary hypertension (PHT) by examining (1) the effects of ...

journal_title：Circulation research

authors： Keegan A,Morecroft I,Smillie D,Hicks MN,MacLean MR

更新日期：2001-12-07 00:00:00

abstract：:The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular in...

journal_title：Circulation research

authors： Sandberg WJ,Halvorsen B,Yndestad A,Smith C,Otterdal K,Brosstad FR,Frøland SS,Olofsson PS,Damås JK,Gullestad L,Hansson GK,Oie E,Aukrust P

更新日期：2009-01-02 00:00:00

abstract：:The regeneration of new myocardium by stem or progenitor cells is an important therapeutic option. Cellular or nuclear fusion is considered as an alternative to cell reprogramming by transdifferentiation. However, the generation of hybrid cells may also be a consequence of a transient transmembrane exchange of protein...

journal_title：Circulation research

authors： Koyanagi M,Brandes RP,Haendeler J,Zeiher AM,Dimmeler S

更新日期：2005-05-27 00:00:00

abstract：:Mechanical overload elicits functional and structural adaptive mechanisms in cardiac muscle. Signaling pathways linked to integrin/cytoskeleton complexes may have a function in mediation of the effects of mechanical stimulus in myocardial cells. We investigated the tyrosine phosphorylation and the assembly of the mult...

journal_title：Circulation research

authors： Franchini KG,Torsoni AS,Soares PH,Saad MJ

更新日期：2000-09-29 00:00:00

abstract：:In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in the formation of a collagen-based scar. Necrotic cells release danger signals, activating innate immune pathways and triggering an intense inflammatory response. Stimula...

journal_title：Circulation research

authors： Prabhu SD,Frangogiannis NG

更新日期：2016-06-24 00:00:00

abstract：RATIONALE:Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy. OBJECTIVE:We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothes...

journal_title：Circulation research

authors： Williams AR,Trachtenberg B,Velazquez DL,McNiece I,Altman P,Rouy D,Mendizabal AM,Pattany PM,Lopera GA,Fishman J,Zambrano JP,Heldman AW,Hare JM

更新日期：2011-04-01 00:00:00