Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes?

abstract：:The activity of the adrenergic system plays an important role in the genesis of malignant arrhythmias and the spreading of the infarcted zone in acute myocardial ischemia. Acute myocardial ischemia induces an increased activity of adenylyl cyclase. This sensitization at the enzyme level as shown in the isolated perfus...

journal_title：Circulation research

authors： Strasser RH,Braun-Dullaeus R,Walendzik H,Marquetant R

更新日期：1992-06-01 00:00:00

abstract：RATIONALE:Despite significant interest in bone marrow mononuclear cell (BMC) therapy for ischemic heart disease, current techniques have resulted in only modest benefits. However, selected patients have shown improvements after autologous BMC therapy, but the contributing factors are unclear. OBJECTIVE:The purpose of ...

journal_title：Circulation research

authors： Schutt RC,Trachtenberg BH,Cooke JP,Traverse JH,Henry TD,Pepine CJ,Willerson JT,Perin EC,Ellis SG,Zhao DX,Bhatnagar A,Johnstone BH,Lai D,Resende M,Ebert RF,Wu JC,Sayre SL,Orozco A,Zierold C,Simari RD,Moyé L,Cogle

更新日期：2015-01-02 00:00:00

abstract：:The impact of vanadate on the Na,K-ATPase system in the vascular smooth muscle cell is poorly understood. The present study describes the kinetics of the effect of vanadate on Na,K-ATPase and the Na-K pump in in vitro grown rat VSMC's. Vanadate interaction with the Na,K-ATPase system in vascular smooth muscle cells wa...

journal_title：Circulation research

authors： Searle BM,Higashino H,Khalil F,Bogden JD,Tokushige A,Tamura H,Kino M,Aviv A

更新日期：1983-08-01 00:00:00

abstract：:There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs frequently prescribed to lower cholesterol. However, in spite of their wide-spread use, discontinuation and nonadherence remains a major gap ...

journal_title：Circulation research

authors： Ward NC,Watts GF,Eckel RH

更新日期：2019-01-18 00:00:00

abstract：:Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...

journal_title：Circulation research

authors： Liu DW,Gintant GA,Antzelevitch C

更新日期：1993-03-01 00:00:00

abstract：:Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized alpha4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endoth...

journal_title：Circulation research

authors： Goldfinger LE,Tzima E,Stockton R,Kiosses WB,Kinbara K,Tkachenko E,Gutierrez E,Groisman A,Nguyen P,Chien S,Ginsberg MH

更新日期：2008-07-18 00:00:00

abstract：:We previously have shown that alpha-adrenergic stimulation of canine Purkinje fibers and rat ventricle decreases automaticity. Experiments on rat ventricular myocytes in tissue culture have suggested that the decrease in automaticity induced by alpha-adrenergic stimulation depends on the development of sympathetic inn...

journal_title：Circulation research

authors： Rosen MR,Steinberg SF,Chow YK,Bilezikian JP,Danilo P Jr

更新日期：1988-02-01 00:00:00

abstract：:We used a genetic approach to determine whether increasing the level of A3 adenosine receptors (A3ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A3tg.1) or six (A3tg.6) copies of a transgene consisting of the cardiomyocyte-specific alp...

journal_title：Circulation research

authors： Black RG Jr,Guo Y,Ge ZD,Murphree SS,Prabhu SD,Jones WK,Bolli R,Auchampach JA

更新日期：2002-07-26 00:00:00

abstract：:Recent evidence suggests that functional diversity of vascular smooth muscle is produced in part by a differential expression of ion channels. The aim of the present study was to examine the role of Ca(2+)-activated K(+) channels (K(Ca) channels) in the expression of smooth muscle cell functional phenotype. We found t...

journal_title：Circulation research

authors： Neylon CB,Lang RJ,Fu Y,Bobik A,Reinhart PH

更新日期：1999-10-29 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：:In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure...

journal_title：Circulation research

authors： Brown DL,Guyenet PG

更新日期：1985-03-01 00:00:00

abstract：RATIONALE:Significant progress has revealed transcriptional inputs that underlie regulation of artery and vein endothelial cell fates. However, little is known concerning genome-wide regulation of this process. Therefore, such studies are warranted to address this gap. OBJECTIVE:To identify and characterize artery- an...

journal_title：Circulation research

authors： Sissaoui S,Yu J,Yan A,Li R,Yukselen O,Kucukural A,Zhu LJ,Lawson ND

更新日期：2020-03-27 00:00:00

abstract：:Thrombin stimulates synthesis and secretion of endothelin-1 (ET-1), a vasoactive peptide that triggers responses in the vascular endothelium and smooth muscle. We investigated the signal transduction pathways by which thrombin stimulates preproET-1 gene expression and ET-1 peptide secretion in macrovascular cells (hum...

journal_title：Circulation research

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:Giant-cell arteritis (GCA) is a large-vessel vasculitis characterized by immune cell infiltration, yet the potential involvement of neutrophils has rarely been studied. OBJECTIVE:We investigated whether alterations in neutrophil reactivity occurred in the pathogenesis of GCA or during its clinical management...

journal_title：Circulation research

authors： Nadkarni S,Dalli J,Hollywood J,Mason JC,Dasgupta B,Perretti M

更新日期：2014-01-17 00:00:00

abstract：:In myocardial infarction (MI), granulation tissue cells disappear via apoptosis to complete a final scarring with scanty cells. Blockade of this apoptosis was reported to improve post-MI ventricular remodeling and heart failure. However, the molecular biological mechanisms for the apoptosis are unknown. Fas and Fas li...

journal_title：Circulation research

authors： Li Y,Takemura G,Kosai K,Takahashi T,Okada H,Miyata S,Yuge K,Nagano S,Esaki M,Khai NC,Goto K,Mikami A,Maruyama R,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2004-09-17 00:00:00

abstract：RATIONALE:autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is not well understood. OBJECTIVE:we investigated the role of FoxOs and its posttranslational modificat...

journal_title：Circulation research

authors： Hariharan N,Maejima Y,Nakae J,Paik J,Depinho RA,Sadoshima J

更新日期：2010-12-10 00:00:00

abstract：:Studies were performed to determine whether an alteration in coronary vascular resistance and a reduction in the reflow phenomenon occurred in the blood-perfused, heparinized canine heart after various periods of myocaridal ischemia. Regional myocardial blood flow was measured with radioactive microspheres. Proximal l...

journal_title：Circulation research

authors： Willerson JT,Watson JT,Hutton I,Templeton GH,Fixler DE

更新日期：1975-06-01 00:00:00

abstract：:Previous studies have demonstrated that expression of p193 and p53 mutants with dominant-interfering activities renders embryonic stem cell-derived cardiomyocytes responsive to the growth promoting activities of the E1A viral oncoproteins. In this study, the effects of p53 and p193 antagonization on cardiomyocyte cell...

journal_title：Circulation research

authors： Nakajima H,Nakajima HO,Tsai SC,Field LJ

更新日期：2004-06-25 00:00:00

abstract：:The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen...

journal_title：Circulation research

authors： Mukherjee D,Sen S

更新日期：1990-12-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of ER stress proteins, many of which are protective and function to res...

journal_title：Circulation research

authors： Martindale JJ,Fernandez R,Thuerauf D,Whittaker R,Gude N,Sussman MA,Glembotski CC

更新日期：2006-05-12 00:00:00

abstract：:The abundance of membrane cholesterol is an important determinant of the functional properties of biomembranes. To determine whether arterial smooth muscle acquires altered contractile properties in a high cholesterol environment, isolated canine coronary arteries were exposed to cholesterol in stable aqueous solution...

journal_title：Circulation research

authors： Yokoyama M,Henry PD

更新日期：1979-10-01 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accura...

journal_title：Circulation research

authors： Griendling KK,Touyz RM,Zweier JL,Dikalov S,Chilian W,Chen YR,Harrison DG,Bhatnagar A,American Heart Association Council on Basic Cardiovascular Sciences.

更新日期：2016-08-19 00:00:00

abstract：:Cardiac failure appears rapidly during severe hypoxia and precedes a substantial reduction in adenosine triphosphate content. Reduced adenosine triphosphate turnover, in the presence of nearly normal content, may be the metabolic basis for contractile failure during hypoxia. To measure both the myocardial content and ...

journal_title：Circulation research

authors： Bittl JA,Balschi JA,Ingwall JS

更新日期：1987-06-01 00:00:00

abstract：:We studied the effects of a thrombolytic agent (t-PA) and a thromboxane synthetase inhibitor (CGS-13080) in a model of myocardial ischemia and reperfusion. Occlusion of the left anterior descending coronary artery for 2 hours followed by 4 hours of reperfusion in anesthetized cats results in a large washout of creatin...

journal_title：Circulation research

authors： Lefer AM,Mentley R,Sun JZ

更新日期：1988-09-01 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：:We have previously studied the relation between long-chain fatty acid and pyruvate metabolism in reperfused myocardium and noted a rapid return of fatty acid oxidation to at least preischemic values accompanied by a marked decrease in pyruvate oxidation. The purpose of the present report is to further characterize car...

journal_title：Circulation research

authors： Renstrom B,Nellis SH,Liedtke AJ

更新日期：1989-10-01 00:00:00

abstract：:We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid [EVF]) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were di...

journal_title：Circulation research

authors： Laine GA,Allen SJ

更新日期：1991-06-01 00:00:00

abstract：:To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte...

journal_title：Circulation research

authors： Olivetti G,Melissari M,Capasso JM,Anversa P

更新日期：1991-06-01 00:00:00

abstract：:Cyclic GMP (cGMP) kinase is intimately involved in the regulation of vascular smooth muscle tone. Its tissue concentration was determined in normotensive and hypertensive rats by use of monospecific anti-cGMP kinase antibodies. Hearts of spontaneously hypertensive rats and renovascular (Goldblatt II) hypertensive rats...

journal_title：Circulation research

authors： Ecker T,Göbel C,Hullin R,Rettig R,Seitz G,Hofmann F

更新日期：1989-11-01 00:00:00