Contractile failure and high-energy phosphate turnover during hypoxia: 31P-NMR surface coil studies in living rat.

abstract：:In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure...

journal_title：Circulation research

authors： Brown DL,Guyenet PG

更新日期：1985-03-01 00:00:00

abstract：:Alterations in voltage-dependent Ca2+ channels in the arterial smooth muscle cells of spontaneously hypertensive rats (SHR) were investigated using the whole-cell voltage clamp and compared with Wistar-Kyoto (WKY) rats. Single cells were freshly isolated from resistance mesenteric arteries from 4- to 5-week-old (young...

journal_title：Circulation research

authors： Ohya Y,Abe I,Fujii K,Takata Y,Fujishima M

更新日期：1993-12-01 00:00:00

abstract：RATIONALE:Myofibroblasts are believed to evolve from precursor cells; however, whether noncardiomyocyte cardiac cells (NMCCs; ie, endothelial cells, smooth muscle cells, pericytes, and fibroblasts) that have been derived from human-induced pluripotent stem cells (hiPSCs) can transdifferentiate into myofibroblast-like c...

journal_title：Circulation research

authors： Gao L,Yang L,Wang L,Geng Z,Wei Y,Gourley G,Zhang J

更新日期：2018-12-07 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally develop severe pulmonary vascular obstructive disease. To understand what underlies this propensity, we compared the pulmonary vascular hemodynamic and structural features of S100A4/Mts1 with control C57Bl/6 mice at baseline, followi...

journal_title：Circulation research

authors： Merklinger SL,Wagner RA,Spiekerkoetter E,Hinek A,Knutsen RH,Kabir MG,Desai K,Hacker S,Wang L,Cann GM,Ambartsumian NS,Lukanidin E,Bernstein D,Husain M,Mecham RP,Starcher B,Yanagisawa H,Rabinovitch M

更新日期：2005-09-16 00:00:00

abstract：:Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subty...

journal_title：Circulation research

authors： McNally EM,Mestroni L

更新日期：2017-09-15 00:00:00

abstract：:The small (21 kDa) guanine nucleotide-binding protein (small G protein) superfamily comprises 5 subfamilies (Ras, Rho, ADP ribosylation factors [ARFs], Rab, and Ran) that act as molecular switches to regulate numerous cellular responses. Cardiac myocyte hypertrophy is associated with cell growth and changes in the cyt...

journal_title：Circulation research

authors： Clerk A,Sugden PH

更新日期：2000-05-26 00:00:00

abstract：:A number of neurotransmitters modulate cardiac dihydropyridine-sensitive L-type Ca2+ channels through several homologous G protein-coupled receptors. Previous studies that have examined receptor-Ca2+ channel interactions have suffered because of the coexpression of various receptor subtypes in native cells. To study t...

journal_title：Circulation research

authors： Yatani A,Wakamori M,Niidome T,Yamamoto S,Tanaka I,Mori Y,Katayama K,Green S

更新日期：1995-03-01 00:00:00

abstract：:Abnormalities of myocardial gap junction-mediated cell coupling have been implicated in cardiac arrhythmogenesis. The potential role of gap junctional dysfunction in the generation of reperfusion-induced arrhythmias is uncertain. The purpose of this study was to measure the effects of myocardial ischemia and reperfusi...

journal_title：Circulation research

authors： Kieval RS,Spear JF,Moore EN

更新日期：1992-07-01 00:00:00

abstract：RATIONALE:Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cells (LMCs) and their electrical coupling through Cxs, Cx-related lym...

journal_title：Circulation research

authors： Castorena-Gonzalez JA,Zawieja SD,Li M,Srinivasan RS,Simon AM,de Wit C,de la Torre R,Martinez-Lemus LA,Hennig GW,Davis MJ

更新日期：2018-09-28 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:The paraoxonase (PON) gene cluster consists of the PON1, PON2, and PON3 genes, each of which can individually inhibit atherogenesis. To analyze the functions of the PON gene cluster (PC) in atherogenesis and plaque stability, human PC transgenic (Tg) mice were generated using bacterial artificial chromosome. The high-...

journal_title：Circulation research

authors： She ZG,Zheng W,Wei YS,Chen HZ,Wang AB,Li HL,Liu G,Zhang R,Liu JJ,Stallcup WB,Zhou Z,Liu DP,Liang CC

更新日期：2009-05-22 00:00:00

abstract：:Diabetes mellitus has profound adverse effects on vascular and, in particular, endothelial function. Although pressure-induced constriction ("myogenic tone") is a major contributor to the regulation of blood flow, little is known about the effects of diabetes on this response. Diabetes has been shown to diminish the d...

journal_title：Circulation research

authors： Zimmermann PA,Knot HJ,Stevenson AS,Nelson MT

更新日期：1997-12-01 00:00:00

abstract：:The alpha-adrenergic blocking drugs, phentolamine and Hydergine, both act centrally at different sites to depress and enhance the pressor and sympathetic nerve response to decreased baroreceptor afferent input in anesthetized cats. Depression of the rise in blood pressure and sympathetic nerve discharge during bilater...

journal_title：Circulation research

authors： Tadepalli AS,Mills E,Schanberg SM

更新日期：1976-11-01 00:00:00

abstract：:Computer simulations and nonlinear dynamics have provided invaluable tools for illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this approach has led to major insights into the mechanisms of spatially discordant alternans, a key arrhythmogenic factor predisposing the heart to re-entry...

journal_title：Circulation research

authors： Weiss JN,Karma A,Shiferaw Y,Chen PS,Garfinkel A,Qu Z

更新日期：2006-05-26 00:00:00

abstract：:Calcium uptake was measured in homogenates and microsomal preparations enriched in sarcoplasmic reticulum vesicles isolated from hearts of hypertrophic (BIO 14.6) and dilated (BIO 53.58) cardiomyopathic as well as control (F1B) Syrian hamsters at 3, 7, 9, and 11 months of age. Calcium uptake studies were done using th...

journal_title：Circulation research

authors： Whitmer JT,Kumar P,Solaro RJ

更新日期：1988-01-01 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) trans...

journal_title：Circulation research

authors： Litwin SE,Zhang D,Bridge JH

更新日期：2000-11-24 00:00:00

abstract：RATIONALE:Congestive heart failure (CHF) frequently results in remodeling and increased tone of pulmonary resistance vessels. This adaptive response, which aggravates pulmonary hypertension and thus, promotes right ventricular failure, has been attributed to lung endothelial dysfunction. OBJECTIVE:We applied real-time...

journal_title：Circulation research

authors： Kerem A,Yin J,Kaestle SM,Hoffmann J,Schoene AM,Singh B,Kuppe H,Borst MM,Kuebler WM

更新日期：2010-04-02 00:00:00

abstract：:Choline acetyltransferase activity, which is rate limiting in acetylcholine biosynthesis, was measured in the four heart chambers of guinea pigs subjected to (1) sham surgery, (2) constriction of the ascending aorta, (3) constriction of the descending thoracic aorta, and (4) constriction of the pulmonary artery. After...

journal_title：Circulation research

authors： Roskoski R Jr,Schmid PG,Mayer HE,Abboud FM

更新日期：1975-04-01 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：:Pathological remodeling of the left ventricle (LV) after myocardial infarction (MI) is a major cause of heart failure. Although cardiac hypertrophy after increased loading conditions has been recognized as a clinical risk factor for human heart failure, it is unknown whether post-MI hypertrophic remodeling of the myoc...

journal_title：Circulation research

authors： van Rooij E,Doevendans PA,Crijns HJ,Heeneman S,Lips DJ,van Bilsen M,Williams RS,Olson EN,Bassel-Duby R,Rothermel BA,De Windt LJ

更新日期：2004-02-20 00:00:00

abstract：:Adipose tissue (AT) can accumulate macrophages and secrete several inflammatory mediators. Despite its pivotal role in the progression of chronic inflammatory processes such as atherosclerosis, the adaptive role of immunity in obesity remains poorly explored. Visceral AT of diet-induced obese C57BL/6 mice had higher n...

journal_title：Circulation research

authors： Rocha VZ,Folco EJ,Sukhova G,Shimizu K,Gotsman I,Vernon AH,Libby P

更新日期：2008-08-29 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Volume expansion has been shown to increase plasma atrial natriuretic peptide (ANP) levels, but the precise role of paracrine and autocrine factors in stretch-induced cardiac hormone release is not clear. In the present study, we report the effects of endothelin (ET) and angiotensin receptor (AT receptor) antagonists ...

journal_title：Circulation research

authors： Leskinen H,Vuolteenaho O,Ruskoaho H

更新日期：1997-01-01 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studi...

journal_title：Circulation research

authors： McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

更新日期：2018-04-27 00:00:00

abstract：:A series of new phenylethanolamines with 2-methoxy and/or 4-methyl, 4-chloro, or 4-bromo ring substituents and either N-isopropyl or N-tert butyl substituents have been synthesized and tested for beta 1- and beta 2-adrenoceptor blocking activity using isolated guinea pig atrial and tracheal preparations. Each of the d...

journal_title：Circulation research

authors： Letts LG,Temple DM,Williams LR

更新日期：1980-06-01 00:00:00

abstract：:To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte...

journal_title：Circulation research

authors： Olivetti G,Melissari M,Capasso JM,Anversa P

更新日期：1991-06-01 00:00:00

abstract：:Selective troponin I (TnI) modification has been demonstrated to be in part responsible for the contractile dysfunction observed with myocardial ischemia/reperfusion injury. We have isolated and characterized modified TnI products in isolated rat hearts after 0, 15, or 60 minutes of ischemia followed by 45 minutes of ...

journal_title：Circulation research

authors： McDonough JL,Arrell DK,Van Eyk JE

更新日期：1999-01-08 00:00:00